As synthetic biology transforms living matter into a medium for making, what is the role of design and its associated values?
Investigating Synthetic Biology's Designs on Nature
Author: Alexandra Daisy Ginsberg,Jane Calvert,Pablo Schyfter,Alistair Elfick,Drew Endy
Publisher: MIT Press
In the final years of the twentieth century, emigres from mechanical and electrical engineering and computer science resolved that if the aim of biology was to understand life, then making life would yield better theories than experimentation. Sophia Roosth, a cultural anthropologist, takes us into the world of these self-named synthetic biologists who, she shows, advocate not experiment but manufacture, not reduction but construction, not analysis but synthesis. Roosth reveals how synthetic biologists make new living things in order to understand better how life works. What we see through her careful questioning is that the biological features, theories, and limits they fasten upon are determined circularly by their own experimental tactics. This is a story of broad interest, because the active, interested making of the synthetic biologists is endemic to the sciences of our time."
How Life Got Made
Author: Sophia Roosth
Publisher: University of Chicago Press
Presented here is the final and most coherent section of a sweeping classic work in environmental history, The Unending Frontier. The World Hunt focuses on the commercial hunting of wildlife and its profound global impact on the environment and the early modern world economy. Tracing the massive expansion of the European quest for animal products, The World Hunt explores the fur trade in North America and Russia, cod fishing in the North Atlantic, and whaling and sealing on the world’s oceans and coastlands.
An Environmental History of the Commodification of Animals
Author: John F. Richards
Publisher: Univ of California Press
Bioluminescent algae, symbiotic aquariums, self-healing concrete, clavicle wind instruments and structures made from living trees - biology applied outside the lab has never been so intriguing, or so beautiful. Bio Design examines the thrilling advances in the field, showcasing some seventy projects (concepts, prototypes and completed designs) that cover a range of fields - from architecture and industrial design to fashion and medicine. The revised and expanded edition features twelve new projects (replacing ten existing projects): Hy-Fi (by David Benjamin); One Central Park, Sydney (Jean Nouvel); Guard from Above (Sjoerd Hoogendoorn); Cell-laden Hydrogels for Biocatalysis (Alshakim Nelson); Zoa (Modern Meadow); Amino Labs (Julie Legault); Algae and Mycelium Projects (Eric Klarenbeek); Interwoven and Harvest (Diane Scherer); Concrete Honey (John Becker); Bistro In Vitro (Koert van Mensvoort); Circumventive Organs (Agi Haines); Quantworm Mine (Liv Bargman and Nina Cutler). It also includes a new 'how-to' section at the end (Tips for Collaboration/FAQs/Further Resources), as well as a fully revised introduction.
Nature * Science * Creativity
Author: William Myers
Publisher: Thames & Hudson
In Biology Is Technology, author Robert Carlson offers a uniquely informed perspective on the endeavors that contribute to current progress in the science of biological systems and the technology used to manipulate them.
Author: Robert H. Carlson
Publisher: Harvard University Press
Thanks to advances in molecular science and microscopy, we can visualize matter on a nanoscale, and structures not visible to the naked eye can be visualized and characterized. The fact that technology allows us to transcend the limits of natural perception and see what was previously unseeable creates a new dimension of aesthetic experience and practice: molecular aesthetics. This book, drawing on an exhibit and symposium at ZKM | Center for Art and Media Karlsruhe, documents aesthetic developments in what Félix Guattari called the "molecular revolution." Just as artists in the Bauhaus movement began to use such industrial materials as metal, Plexiglas, and alloys as raw materials, artists today have access to new realms of the molecular and nano. The industrial aesthetic of machinery and material has been transformed into an aesthetic of media and molecules. Molecular Aesthetics suggests ways in which art can draw inspiration from the molecular sciences -- and ways in which science can use art to make experimental results more intelligible and comprehensible. The authors of the essays collected in the book discuss the creation of molecules of remarkable beauty and the functional properties that stem from a few geometrical principles of molecular design; address the history of molecular structure representation; examine the meaning of molecular aesthetics for scientists; and compare chemical structures to artworks.
Author: Peter Weibel,Ljiljana Fruk
Publisher: MIT Press (MA)
A science book like no other, The Where, the Why, and the How turns loose 75 of today's hottest artists onto life's vast questions, from how we got here to where we are going. Inside these pages some of the biggest (and smallest) mysteries of the natural world are explained in essays by real working scientists, which are then illustrated by artists given free rein to be as literal or as imaginative as they like. The result is a celebration of the wonder that inspires every new discovery. Featuring work by such contemporary luminaries as Lisa Congdon, Jen Corace, Neil Farber, Susie Ghahremani, Jeremyville, and many more, this is a work of scientific and artistic exploration to pique the interest of both the intellectually and imaginatively curious.
75 Artists Illustrate Wondrous Mysteries of Science
Author: Matt Lamothe,Julia Rothman,Jenny Volvovski
Publisher: Chronicle Books
Synthetic Biology: A Lab Manual is the first manual for laboratory work in the new and rapidly expanding field of synthetic biology. Aimed at non-specialists, it details protocols central to synthetic biology in both education and research. In addition, it provides all the information that teachers and students from high schools and tertiary institutions need for a colorful lab course in bacterial synthetic biology using chromoproteins and designer antisense RNAs. As a bonus, practical material is provided for students of the annual international Genetically Engineered Machine (iGEM) competition. The manual is based upon a highly successful course at Sweden's Uppsala University and is coauthored by one of the pioneers of synthetic biology and two bioengineering postgraduate students. An inspiring foreword is written by another pioneer in the field, Harvard's George Church: “Synthetic biology is to early recombinant DNA as a genome is to a gene. Is there anything that SynBio will not impact? There was no doubt that the field of SynBio needed ‘A Lab Manual’ such as the one that you now hold in your hands.” Read about the interview with the authors! Contents:Introduction:What is Synthetic Biology, Exactly?The iGEM OutbreakA Synthetic Biology Lab ManualGenes, Chromoproteins and Antisense RNAs:E. coli DNA: Chromosomes, Plasmids and Copy NumberCoupling of Transcription and Translation in BacteriaPromoter and Terminator for TranscriptionRibosome Binding Site (RBS)Codon BiasChromoproteinsSmall Regulatory RNAs (sRNAs)Lab Rooms and Equipment:The Physical Lab SpacesEquipmentSafety is Priority #1:FiresChemicalsBiological Safety and DisposalDangerous EquipmentLab Course Projects:Time and ResourcesProject Overview and Learning ObjectivesThe Lab NotebookLab Section 1. Preparation of Chemical Solutions and Agar PlatesLab Section 2. Coloring Bacteria by Adding a Promoter to a Chromoprotein GeneLab Section 3: Rational Engineering of Chromoprotein Expression LevelLab Section 4. Other ExperimentsThe “Dreaded” ExamProtocols:IntroductionProtocol 1. Preparation of Solutions and Agar PlatesProtocol 2. Overnight Cultures with Antibiotics, and Glycerol StocksProtocol 3. BioBrick™ 3A Assembly and Gel AnalysisProtocol 4. Agarose Gel ElectrophoresisProtocol 5. Preparation of Competent E. coli Cells Using CaCl2Protocol 6. Transformation of CaCl2-Competent E. coli CellsProtocol 7. Bacterial Re-Streaking TechniquesProtocol 8. Lysis of E. coli Cells with LysozymeProtocol 9. Polymerase Chain Reaction (PCR)Protocol 10. Inverse PCR MutagenesisProtocol 11. Colony PCRProtocol 12. Gibson AssemblyAdvanced Methods:Flow Cytometry and Cell SortingRecombination in Plasmids and the ChromosomeElectrocompetent CellsThe International Genetically Engineered Machine (iGEM) Competition:How to Start an iGEM TeamUppsala iGEM 2011 — Show Color with ColorUppsala iGEM 2012 — Resistance is FutileUppsala iGEM 2013 — Lactonutritious — It's DeliciousAppendices Readership: Students and researchers in biotechnology, cell/molecular biology and genetics. Keywords:Synthetic Biology;Genetic Engineering;DNA Cloning;Polymerase Chain Reaction;Molecular Biology;Laboratory;Biobrick;Chromoprotein;Manual;CourseReviews: It provides an introductory workflow for common techniques and would be of definite use to educators wanting to bring synthetic biology into the classroom or for motivated undergraduate students with the desire to start thir own iGEM team.” Synthetic Biology See Full Review
A Lab Manual
Author: Josefine Liljeruhm,Erik Gullberg,Anthony C Forster
Publisher: World Scientific
List of figures. Preface to the 1992 edition. Preface. The general setting. A formal framework. lustrations. Schemata. The optimal allocation of trials. Reproductive plans and genetic operators. The robustness of genetic plans. Adaptation of codings and representations. An overview. Interim and prospectus. Glossary of important symbols.
An Introductory Analysis with Applications to Biology, Control, and Artificial Intelligence
Author: John Henry Holland
Publisher: MIT Press
Author: Andrea Grover
Category: Art and science
Edited by Joke Brouwer, Arjun Appadurai, Bruce Sterling, Gunnar Heinsohn, Lynn Margulis, Raj Patel.
Author: Joke Brouwer
Publisher: V2_ publishing
Material Alchemy has been devised to showcase the most innovative, thought-provoking design approaches to materials within the 21st century. Enlisting the help of luminaries from the world of science, technology, and design showcases new responses to material innovation and provides key insights into how material will be utilised to shape our future environments. Unlike existing publications that singularly examine and showcase materials from an industrial and technical standpoint for commercial application, this publication explores materials from a conceptual, historical and narrative point of view. Exploring key topics such as synthetic biology, how designers and scientists are designing with living matter, utilising the laboratory as a means to cultivate and grow new materials. To technological innovations, how new technologies such as 3D printing are revolutionising the manufacturing industry. Showcasing the work by technologists and artisans, how these collaborative partnerships are evolving to redefine materiality in the 21st century. The book not only provides new insights into how designers, scientists and artisans are exploring materiality, it also presents opportunities to physically engage with materials through the following chapters: Low-Tech, High-Tech, Molecular Gastronomy and The Laboratory. In addition to this, the publication features interactive content that merges the analogue with the digital. Using image recognition software to trigger hidden content in the form of animations that visually demonstrate how to carry out each workshop, or to transport you to the alchemists conceptual film to further explain the narrative of their research. The use of materials within art, design and architecture is a dynamic and growing area of research. How we use and define a material no longer applies in the 21st century, a material is more than just a material to clothe and shelter us, our desire for intrinsic value and connectedness has driven the way for new interpretations of materiality, as opposed to merely applying materials for commercial applications.
Author: Jenny Lee
Publisher: Bis Pub
Category: Business & Economics
Evolution, Explanation, Ethics and Aesthetics: Towards a Philosophy of Biology focuses on the dominant biological topic of evolution. It deals with the prevailing philosophical themes of how to explain the adaptation of organisms, the interplay of chance and necessity, and the recurrent topics of emergence, reductionism, and progress. In addition, the extensively treated topic of how to explain human nature as a result of natural processes and the encompassed issues of the foundations of morality and the brain-to-mind transformation is discussed. The philosophy of biology is a rapidly expanding field, not more than half a century old at most, and to a large extent is replacing the interest in the philosophy of physics that prevailed in the first two-thirds of the twentieth century. Few texts available have the benefit of being written by an eminent biologist who happens to be also a philosopher, as in this work. This book is a useful resource for seminar courses and college courses on the philosophy of biology. Researchers, academics, and students in evolutionary biology, behavior, genetics, and biodiversity will also be interested in this work, as will those in human biology and issues such as ethics, religion, and the human mind, along with professional philosophers of science and those concerned with such issues as whether evolution is compatible with religion and/or where morality comes from. Presents the unique perspective of a distinguished biologist with extensive experience in the field who has published much about the subject in a wide variety of journals and edited volumes Covers the philosophical issues related to evolution and biology in an approachable and readable style Includes the most up-to-date treatment of this burgeoning, exciting field within biology Provides the ideal guide for researchers, academics, and students in evolutionary biology, behavior, genetics, and biodiversity
Towards a Philosophy of Biology
Author: Francisco J. Ayala
Publisher: Academic Press
Today’s synthetic biologists are in the early stages of engineering living cells to help treat diseases, sense toxic compounds in the environment, and produce valuable drugs. With this manual, you can be part of it. Based on the BioBuilder curriculum, this valuable book provides open-access, modular, hands-on lessons in synthetic biology for secondary and post-secondary classrooms and laboratories. It also serves as an introduction to the field for science and engineering enthusiasts. Developed at MIT in collaboration with award-winning high school teachers, BioBuilder teaches the foundational ideas of the emerging synthetic biology field, as well as key aspects of biological engineering that researchers are exploring in labs throughout the world. These lessons will empower teachers and students to explore and be part of solving persistent real-world challenges. Learn the fundamentals of biodesign and DNA engineering Explore important ethical issues raised by examples of synthetic biology Investigate the BioBuilder labs that probe the design-build-test cycle Test synthetic living systems designed and built by engineers Measure several variants of an enzyme-generating genetic circuit Model "bacterial photography" that changes a strain’s light sensitivity Build living systems to produce purple or green pigment Optimize baker’s yeast to produce ?-carotene
Synthetic Biology in the Lab
Author: Natalie Kuldell PhD.,Rachel Bernstein,Karen Ingram,Kathryn M Hart
Publisher: "O'Reilly Media, Inc."
Over the coming decades, Artificial Intelligence will profoundly impact the way we live, work, wage war, play, seek a mate, educate our young, and care for our elderly. It is likely to greatly increase our aggregate wealth, but it will also upend our labor markets, reshuffle our social order, and strain our private and public institutions. Eventually it may alter how we see our place in the universe, as machines pursue goals independent of their creators and outperform us in domains previously believed to be the sole dominion of humans. Whether we regard them as conscious or unwitting, revere them as a new form of life or dismiss them as mere clever appliances, is beside the point. They are likely to play an increasingly critical and intimate role in many aspects of our lives. The emergence of systems capable of independent reasoning and action raises serious questions about just whose interests they are permitted to serve, and what limits our society should place on their creation and use. Deep ethical questions that have bedeviled philosophers for ages will suddenly arrive on the steps of our courthouses. Can a machine be held accountable for its actions? Should intelligent systems enjoy independent rights and responsibilities, or are they simple property? Who should be held responsible when a self-driving car kills a pedestrian? Can your personal robot hold your place in line, or be compelled to testify against you? If it turns out to be possible to upload your mind into a machine, is that still you? The answers may surprise you.
What Everyone Needs to Know
Author: Jerry Kaplan
Publisher: Oxford University Press
The biggest challenge in any marketplace is uncertainty. The major changes taking place in world economies, politics, and demographics has raised market uncertainty to its highest level in the past 50 years. However, with new markets opening up in emerging and developing economies, the opportunities have never been better. To compete in this challenging atmosphere, product design/redesign and manufacturing must be integrated to produce better quality products faster and cheaper. Design Synthesis: Integrated Product and Manufacturing System Design provides a conceptual framework and methodologies to do just that. The book explains how to integrate innovative product design with the design of a batch manufacturing system. It covers the technical and social aspects of integration, presents research and best practices, and embeds integration within a framework of sustainable development. It covers the two methods for achieving design synthesis: integration and harmonisation. Product, manufacturing system, and social system architectures are integrated (united or combined to form a whole that is greater than the sum of the parts). The concurrent processes to design the architectures are harmonised (made compatible or coincident with one another). Wide in scope, the book supplies a multi-disciplinary perspective and an extensive discussion on how to maintain integrity during the design process. The authors present research and practices that are difficult or almost impossible to find. They describe the different types of system lifecycles and include guidelines on how to select the appropriate lifecycle for a specific design situation.
Integrated Product and Manufacturing System Design
Author: Graeme Arthur Britton,Seppo Torvinen
Publisher: CRC Press
Category: Technology & Engineering
Material Matters: New Materials in Design explores the fascinating world of materials, surveying characteristics, properties and new applications of materials in diverse fields, from sustainable resources to medicine, architectural design to aeronautical engineering and interior design to ‘haute-culture’ and fashion. Material Matters profiles the most fascinating materials developed in recent years with full page profiles and colorful illustrations, examples include Aerogel or ‘frozen smoke’—used by NASA it is the lightest solid on earth at 95% air. Amongst the detailed profiles are texts that discuss the fusion between science, art and design in the creation of these substances and their importance within contemporary living, sustainability and expanding technologies. The book also includes the work of cutting edge designers Marc Newson, Ross Lovegrove, Apple, NASA, Intel, Ron Arad and household names.
New Materials in Design
Author: Philip Howes,Zoe Laughlin
Publisher: Black Dog Pub Limited
Open Design Now looks at design in the new networked world. Design is undergoing a revolution thanks to two forces: an emerging networked community that shares digital information about physical products and widespread availability of production tools and facilities. Design is becoming an open discipline, in which ideas are shared and a wide range of products is being renewed in a worldwide collaborative process. Open design empowers anybody and everybody to devise and distribute their own products, as it has happened in graphic design, music and film before. Curated and edited by Premsela Foundation, Creative Commons and Waag Society this book presents essays, case studies and a lexicon of images related to the main topics. “Openness is more than a commercial and cultural issue. It’s a matter of survival.” - John Thackara How 3D printing is changing design-as-we-know-it The first comprehensive reader on this exciting topic
Why Design Cannot Remain Exclusive
Author: Bas van Abel,Lucas Evers,Peter Troxler,Roel Klaassen
Publisher: BIS Publishers