Molecular Genetics

Author: Jodi A. Lindsay

Publisher: Horizon Scientific Press

ISBN: 1904455298

Category: Science

Page: 278

View: 394

Focusing on the staphylococcal genetics, this title brings together the expertise and enthusiasm of an international panel of leading staphylococcal researchers to provide a state-of-the-art overview of the field.
Posted in Science

Molecular Biology of the Staphylococci

Author: Richard P. Novick

Publisher: N.A


Category: Biologie moléculaire - Congrès

Page: 639

View: 8401

Posted in Biologie moléculaire - Congrès

Molecular Typing in Bacterial Infections

Author: Ivano de Filippis,Marian L. McKee

Publisher: Springer Science & Business Media

ISBN: 1627031855

Category: Science

Page: 484

View: 1314

Molecular Typing in Bacterial Infections covers common bacterial pathogenic agents, with the most effective methods for their identification and classification in the light of their specific epidemiology. The book will be a valuable resource for molecular typing of infectious diseases agents encountered in both the research and hospital clinical lab settings, as well as culture collections. Each chapter provides an overview of molecular approaches to typing bacterial pathogens. Part I gives a general overview of typing methods used in the traditional microbiology laboratory in comparison to molecular methods of epidemiology. In Part II, the relative strengths and weaknesses of the different methods applicable to the specific agents of infectious diseases are emphasized. Specific emphasis is placed on recent changes and updates in molecular typing.
Posted in Science

Genomes of Foodborne and Waterborne Pathogens

Author: Pina Fratamico,Yanhong Liu,Sophia Kathariou

Publisher: American Society for Microbiology Press

ISBN: 1555814573

Category: Science

Page: 380

View: 3225

Detailed interpretation of the environmental consequences of the latest findings from genome sequencing studies—presenting both scientific and public health opportunities. • Explains how understanding pathogen genomics can help ensure the safety of global food and water supplies. • Focuses on specific food- and waterborne pathogens that represent major public health threats. • Examines how global trends, such as climate change, increasing human populations, and rising levels of pollution, are stressing the ecosystems that food- and waterborne pathogens encounter, forcing them to adapt. • Serves as an excellent text for microbiology and genomics researchers, public health officials, regulators, food scientists, and other applicable professionals.
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Author: Greg A. Somerville

Publisher: Caister Academic Press

ISBN: 1910190500

Category: Medical

Page: 398

View: 356

In the twenty first century, the bacterium Staphylococcus aureus continues to be a global threat to human and animal health. There is currently no vaccine for preventing S. aureus infections and the bacterium has developed resistance to many, if not most, antibiotics, hence the therapeutic options are rapidly disappearing. The genetic and physiological flexibility that allows this commensal bacterium to become a powerful pathogen and elucidating the myriad of mechanisms it employs to avoid the host and/or antimicrobials are important areas of research. This book brings together respected S. aureus experts from around the world to provide a timely overview of staphylococcal research. Topics covered include: historical background; medical significance in humans and animals; genetic variation; virulence factors; metabolism and physiology; physiological proteomics; cell wall assembly and physiology; transition metal ion homeostasis; molecular strategies of antibiotic resistance; genetic regulation; and immune response. Essential reading for scientists working with staphylococci. This text is an excellent introduction for entry level scientists, as well as those seeking a deeper understanding of this critically important bacterial pathogen.
Posted in Medical

Food Borne Pathogens and Antibiotic Resistance

Author: Om V. Singh

Publisher: John Wiley & Sons

ISBN: 1119139163

Category: Science

Page: 512

View: 2369

Food is an essential means for humans and other animals to acquire the necessary elements needed for survival. However, it is also a transport vehicle for foodborne pathogens, which can pose great threats to human health. Use of antibiotics has been enhanced in the human health system; however, selective pressure among bacteria allows the development for antibiotic resistance. Foodborne Pathogens and Antibiotic Resistance bridges technological gaps, focusing on critical aspects of foodborne pathogen detection and mechanisms regulating antibiotic resistance that are relevant to human health and foodborne illnesses This groundbreaking guide: • Introduces the microbial presence on variety of food items for human and animal consumption. • Provides the detection strategies to screen and identify the variety of food pathogens in addition to reviews the literature. • Provides microbial molecular mechanism of food spoilage along with molecular mechanism of microorganisms acquiring antibiotic resistance in food. • Discusses systems biology of food borne pathogens in terms of detection and food spoilage. • Discusses FDA’s regulations and Hazard Analysis and Critical Control Point (HACCP) towards challenges and possibilities of developing global food safety. Foodborne Pathogens and Antibiotic Resistance is an immensely useful resource for graduate students and researchers in the food science, food microbiology, microbiology, and industrial biotechnology.
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Staphylococci in Human Disease

Author: Kent B. Crossley,Kimberly K. Jefferson,Gordon L. Archer,Vance G. Fowler

Publisher: John Wiley & Sons

ISBN: 9781444308471

Category: Medical

Page: 640

View: 1364

Staphylococci remain the most important cause of hospital-acquiredinfections in the U.S. and MRSA has become the most common cause ofskin and soft tissue infection in many parts of the world. There is now a much greater understanding of the physiology andevolution of the staphylococci and this new edition reflects therapid advancements in knowledge about this pathogen and provides acomprehensive review from both clinical and basic scienceperspectives. The first section addresses the basic biology of thestaphylococci, their molecular genetics, host defenses and hostevasion, virulence determinants, mechanisms of antibioticresistance, and laboratory techniques. The second section dealswith epidemiology, and the third section provides an overview ofthe varied clinical manifestations of human staphylococcalinfections. The fourth section covers prevention and treatment ofthese often life-threatening infections. Written by experts from around the globe, this book is essentialreading for all clinicians and basic scientists studying thestaphylococci.
Posted in Medical

Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites

Author: Juan-Francisco Martín,Carlos García-Estrada,Susanne Zeilinger

Publisher: Springer

ISBN: 1493911910

Category: Science

Page: 351

View: 1759

This volume describes the more relevant secondary metabolites of different fungi with current information on their biosynthesis and molecular genetics. Bolstered with color illustrations and photographs, the book describes the possible application of molecular genetics to directed strain improvement in great detail. The needs for future developments in this field are also discussed at length Written by authorities in the field, Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites provides a cutting-edge perspective on fungal secondary metabolism and underlying genetics and is a valuable resource for scientists, researchers, and educators in the field of fungal biology.
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Diagnostic Pathology and Molecular Genetics of the Thyroid

A Comprehensive Guide for Practicing Thyroid Pathology

Author: Yuri E. Nikiforov,Paul W. Biddinger,Lester D. R. Thompson

Publisher: Lippincott Williams & Wilkins

ISBN: 1451114559

Category: Medical

Page: 436

View: 3912

Diagnostic Pathology and Molecular Genetics of the Thyroid, Second Edition, offers a comprehensive overview of the diagnostic surgical pathology, cytopathology, immunohistochemistry and molecular genetics of the thyroid diseases, including neoplastic and non-neoplastic conditions. The book provides a detailed description of the surgical pathology of thyroid diseases side by side with major advances in immunohistochemistry and molecular genetics that can be used in evaluating thyroid tumors and non-neoplastic diseases.
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Bacterial Pathogenesis

Methods and Protocols

Author: Frank R. DeLeo,Michael Otto

Publisher: Springer Science & Business Media

ISBN: 1588297403

Category: Medical

Page: 320

View: 6747

Bacterial infections affect world health today as a leading cause of morbidity and mortality. This book presents in-depth methods and state-of-the-art protocols for investigating specific mechanisms of pathogenesis for a wide range of bacteria. Written by experts in the field, this invaluable collection includes protocols to study host-pathogen interactions, animal models of infection, and novel approaches to identifying therapeutic targets designed to control infections.
Posted in Medical

Molecular Techniques for the Study of Hospital Acquired Infection

Author: Steven L. Foley,Anne Y. Chen,Shabbir Simjee,Marcus J. Zervos

Publisher: John Wiley & Sons

ISBN: 9781118063835

Category: Medical

Page: 248

View: 3539

Providing a broad overview of the microbial pathogens associated with hospital-acquired human illness, Techniques for the Study of Hospital Acquired Infection examines the cost-effective use of laboratory techniques in nosocomial infectious disease epidemiology and control. This concise guide addresses the cost benefits of combining modern molecular techniques with the traditional activities of infection control departments. The book is useful as a guide to hospital infection control programs as well as a text for medical practitioners, grad/medical students, researcher scientists, population biologists, molecular biologists, and microbiologists.
Posted in Medical

Staphylococcus aureus Infection and Disease

Author: Allen Honeyman,Herman Friedman,Mauro Bendinelli

Publisher: Springer Science & Business Media

ISBN: 0306468484

Category: Medical

Page: 330

View: 6174

Staphylococcus aureus is now acknowledged as being the most important bacterial pathogen of humans. It usually produces localized disease but can be rapidly invasive, spreading through the tissues, invading bone, and seeding the bloodstream to produce a fulminant picture of septic shock, disseminated intravascular coagulation, and rapid death. Moreover, most strains of staph infections are becoming resistant to most antibiotics, thus posing a significant problem for hospitals and health care facilities. This book, a volume in the Infectious Agents and Pathogenesis series, presents chapters by the major researchers in the field.
Posted in Medical

Molekulare Infektionsbiologie

Interaktionen zwischen Mikroorganismen und Zellen

Author: Jörg Hacker,Jürgen Heesemann

Publisher: Springer Spektrum

ISBN: 9783642394560

Category: Medical

Page: 307

View: 8997

Was passiert im Körper, wenn ein Mensch beispielsweise an Grippe, Malaria oder Lungenentzündung erkrankt? Wie interagieren Bakterien und Viren, Pilze und Parasiten auf molekularer Ebene mit den Zellen des Körpers? Wie wirken die Erreger in den jeweiligen Zellen, wo verstecken sie sich, welche zellulären und molekularen Prozesse werden von diesen gestört oder lahmgelegt? Jörg Hacker und Jürgen Heesemann sowie ihr Autorenteam stellen in diesem Fachbuch die vielfältigen und spannenden Interaktionen zwischen pathogenen Mikroorganismen und ihren Wirtszellen dar. Sie beschreiben die medizinisch bedeutendsten Krankheitserreger, die Infektionen, die sie verursachen und die unspezifischen und spezifischen Mittel, mit denen der Wirt sich dagegen wehren kann. Ausführlich diskutieren sie die Pathogenitätsfaktoren, Proteinsekretionssysteme und die mikrobielle Oberflächenvariation. Weiterhin gehen sie auf die evolutionäre und die zelluläre Infektionsbiologie ein. Molekulare Aspekte der Diagnostik, der Therapie, der Impfstoffentwicklung werden ebenso dargestellt wie die modernen Methoden, mit denen Infektionsbiologen heute arbeiten.
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Staphylococcus Aureus

Molecular and Clinical Aspects

Author: D A Aldeen,K Hiramatsu

Publisher: Elsevier

ISBN: 0857099906

Category: Science

Page: 288

View: 2019

Staphylococcus aureus is resident in skin and nasal membranes with a formidable pathogenic potential to cause a variety of community and hospital acquired infections. This authoritative survey covers the impact of genome sequences into our understanding of MRSA and MSSA pathogenesis. World specialists from America, Germany, Japan, Sweden and the UK contribute knowledge and experience which will be welcome to researchers, practitioners and postgraduate students of immunology, microbiology, bacteriology and pharmacology worldwide. An authoritative survey that covers the impact of genome sequences into the understanding of MRSA and MSSA pathogenesis World specialists from America, Germany, Japan, Sweden and the UK contribute knowledge and experience
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Rapid Detection and Characterization of Foodborne Pathogens by Molecular Techniques

Author: Robert E. Levin

Publisher: CRC Press

ISBN: 9781420092431

Category: Technology & Engineering

Page: 608

View: 1523

Decades of development of the polymerase chain reaction (PCR) have yielded a significant array of associated techniques that make it possible to rapidly detect low numbers of all known pathogenic microorganisms without the traditional, more taxing methods of cultivation and phenotypic characterization. Written by one of the most prolific and respected researchers in food safety, Rapid Detection and Characterization of Foodborne Pathogens by Molecular Techniques describes the application of molecular techniques for the detection and discrimination of major infectious bacteria associated with foods. The book puts a particular focus on genes associated with pathogenicity used in PCR, including real-time PCR for specific detection of pathogenic bacteria and the inherent limitations of such methodology with certain pathogens. It also emphasizes methods for extracting microorganisms from complex food matrices and DNA purification techniques. The coverage begins with a highly comprehensive review of real time PCR, complete with theoretical and operational concepts. Each chapter deals with a specific organism and the techniques applied to that organism. The text includes references on the use of PCR primers and DNA probes, the DNA sequence of each being listed at the end of each chapter to create a complete compendium. This is not a "recipe book", but rather a resource with sufficiently detailed information that allows readers to fully comprehend the methodology described and the significance of the results. Copiously illustrated with figures, tables, charts, and graphs, this is a detailed presentation of the major, contemporary studies involving the molecular detection, quantification, and subspecies differentiation of each organism. With objective assessments of the molecular techniques, their advantages, and limitations, the book allows investigators to readily identify the precise molecular technique and application most suitable for their research.
Posted in Technology & Engineering

Molecular Genetics of Bacterial Pathogenesis

A Tribute to Stanley Falkow

Author: Virginia L. Miller

Publisher: Amer Society for Microbiology


Category: Medical

Page: 529

View: 4727

This volume offers a comprehensive overview of the progress in our understanding the microbial pathogenesis of important bacterial pathogens and also offers insights into how these advances have been made via use of recombinant DNA and other molecular techniques. Dr. Stanley Falkow stimulated much of this research through his own work and that of his students. Dr. Falkow's achievements include seminal discoveries on the nature of plasmids and transposons encoding antibiotic resistance, developing the first DNA probes for the diagnosis of bacterial infections, and being one of the first scientists to study the interactions of a wide variety of bacterial pathogens and host cells. The introductory chapters and selections in Part 1 depict the state of the art at the time when Dr. Falkow and his staff first began their investigations in the 1960s, describe how key experiments arose, and give a flavor of the laboratory environment at that time. The 29 chapters in Parts 2 through 6 are topical reviews of key areas of molecular pathogenesis currently under investigation by alumni of the Falkow laboratory. All of the scientists contributing to this book worked in Dr. Falkow's laboratory. This title is published by the American Society of Microbiology Press and distributed by Taylor and Francis in rest of world territories.
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Immunochemical and molecular genetic analysis of bacterial pathogens

Author: Peter Owen,Federation of European Microbiological Societies,Society for General Microbiology

Publisher: Elsevier Science Ltd

ISBN: 9780444810007

Category: Medical

Page: 342

View: 3370

Posted in Medical