Sigma Receptors

Chemistry, Cell Biology and Clinical Implications

Author: Rae R. Matsumoto,Wayne D. Bowen,Tsung Ping Su

Publisher: Springer Science & Business Media

ISBN: 0387365141

Category: Medical

Page: 413

View: 3047

This book provides an update on sigma receptors, and summarizes recent advances in the medicinal chemistry, molecular biology, and cell biology of sigma receptors. It describes the functional effects mediated by these receptors and the potential clinical implications of these actions. The information is put in a historical perspective. This provides a launching point from which future studies and research directions can easily be developed.
Posted in Medical

The Opiate Receptors

Author: Gavril W. Pasternak

Publisher: Springer Science & Business Media

ISBN: 9781607619932

Category: Medical

Page: 516

View: 7533

This new edition covers the latest knowledge on opiate receptors and related receptor subtypes. It discusses many topics pertaining to the unique integrated approach of correlating the biochemical, physiological and pharmacological aspects of opiate reaction.
Posted in Medical

Sigma Receptors: Their Role in Disease and as Therapeutic Targets

Author: Sylvia B. Smith,Tsung-Ping Su

Publisher: Springer

ISBN: 3319501747

Category: Medical

Page: 312

View: 9754

Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types. It’s putative role in degenerative neuronal diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, pain, drug addiction and locomotor activity. Their roles in possible treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors. Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein.
Posted in Medical

Sigma Receptors

Author: Yossef Itzhak

Publisher: N.A

ISBN: N.A

Category: Medical

Page: 340

View: 9093

This is the 12th in the Neuroscience Perspectives Series. The existence of sigma receptors in the central nervous system has only relatively recently been established. In line with the aims of Neuroscience Perspectives, this volume will cover the historical background of the subject, together with the physiological, molecular biological and pharmacological aspects, with a discussion on the concept of sigma receptors subtypes and their postulated relevance for CNS disorders.
Posted in Medical

Biochemical studies on the sigma-1 receptor

a multidrug binding protein of enigmatic function

Author: Subramaniam Ramachandran,The University of Wisconsin - Madison

Publisher: ProQuest

ISBN: N.A

Category:

Page: 220

View: 7864

The data and findings presented in this thesis area contribute towards understanding the biology of the sigma-1 receptor. The pure sigma-1 receptor is a useful tool that for biochemical and structural experiments which were previously not possible. The work presented here also places sphingosine in the list of possible sigma-1 receptor endogenous ligands. Studies with the K+ channel have uncovered a broader role for sigma ligands in modulating channel regulation.
Posted in

Cancer Research

Author: N.A

Publisher: N.A

ISBN: N.A

Category: Cancer

Page: N.A

View: 5370

Posted in Cancer

Receptor Chemistry Towards the Third Millennium

Author: M. Gianella,G. Marucci,W. Quaglia,U. Gulini

Publisher: Elsevier

ISBN: 9780080540405

Category: Science

Page: 280

View: 6096

Receptor Chemistry Towards the Third Millennium is the result of papers presented at the 12th Camerino-Noordwijkerhout Symposium, held in Camerino, Italy in September 1999. Although much is known about the way ligands interact with receptors, which have now been isolated, characterized and cloned, many aspects still remain to be explored. In particular, differentiation into distinct subpopulations and the multiplicity of transduction processes offer more specific targets in the search for new drugs. This book will be of interest to medicinal chemists, pharmacologists, biochemists and neurologists and will also be a valuable source of reference for medical students and postgraduate students in related fields.
Posted in Science

Delivery Technologies for Biopharmaceuticals

Peptides, Proteins, Nucleic Acids and Vaccines

Author: Lene Jorgensen,Hanne Morck Nielson

Publisher: John Wiley & Sons

ISBN: 0470688408

Category: Science

Page: 442

View: 923

Advances in biotechnology have provided scientists with an increasing number of biopharmaceuticals such as novel peptide and protein drugs as well as nucleic acid based drugs for gene therapy. However, successful delivery of these biopharmaceuticals is a major challenge because their molecular properties lead to poor physical and chemical stability in the body and limited membrane permeability. Therefore researchers are developing a range of new delivery technologies and materials to enable these new drugs to be delivered intact to their target sites. Delivery Technologies for Biopharmaceuticals describes strategies to overcome the main barriers for successful delivery of therapeutic peptides, proteins, and nucleic acid-based drugs or vaccines related to the site of administration and the target site. Many of the approaches described are reported in formulations in current clinical trials as well as in marketed products. Contents include: challenges in delivery of biopharmaceuticals novel formulation approaches for peptide and protein injectables non-viral chemical vectors and viral technology for delivery of nucleic acid based drugs immune response, adjuvants and delivery systems for vaccines several examples of delivery systems for different biopharmaceuticals a critical assessment of delivery technologies for biopharmaceuticals Delivery Technologies for Biopharmaceuticals is an essential single-volume introduction to the technologies used by researchers to ensure efficient delivery of this exciting new class of drugs. It will be of value to researchers and students working in drug delivery, formulation, biopharmaceuticals, medicinal chemistry, and new materials development.
Posted in Science

Medizinische Mikrobiologie

Author: Ernest Jawetz,Joseph L. Melnick,Edward A. Adelberg

Publisher: Springer-Verlag

ISBN: 3662001551

Category: Science

Page: N.A

View: 2827

Die Autoren haben beabsichtigt, diejenigen Gebiete der medizinischen Mikrobiologie kurz, exakt und in ihrem gegenwärtigen Stand darzustellen, die für die Infektionskrankheiten und ihre Chemotherapie von besonderer Bedeutung sind. Das Buch wendet sich in erster Linie an Medizinstudenten, außerdem an alle Ärzte in Krankenhaus und Praxis. Die Notwendigkeit für ein klares Verständnis der mlkrobiologischen Grundtatsachen ist in den letzten Jahren stärker geworden, da in Biochemie, Virologie und Chemotherapie so wie auf weiteren, die Medizin beeinflussenden Gebieten bedeutende Entwicklungen statt gefunden haben. Ein wesendicher Teil dieses Lehrbuches ist deswegen der Darstellung der Grundlagen gewidmet, wodurch sich das Buch auch für die Einführung des Studenten in den mikrobiologischen Kurs als brauchbar erweisen wird. Für die neue Auflage wurde ein Kapitel über Virus und Krebs neu geschrieben, und das Kapitel über antimikrobielle Chemotherapie wurde von Grund auf neu bearbeitet. Die Autoren freuen sich, bei dem Erscheinen der 7. amerikanischen Ausgabe von einer spanischen, deutschen, italienischen und griechischen Ausgabe, sowie von der Vorbereitung für eine serbokroatische Übersetzung berichten zu können. Die Autoren möchten nochmals allen danken, die ihnen bei der Bearbeitung dieser Auf lage behilflich waren, und die es ihnen durch ihre Kommentare und ihre Kritik ermöglicht haben, die in 2jährigen Abständen erscheinenden Revisionen dieses Buches auf dem neu esten Stand zu halten. ERNEsr JAWETZ JOSEPH L MELNICK San Frandsco, August 1966 EnWARD A AnELBERG III Inhaltsverzeichnis 1 Kapitell Die ~lt der Mikroben 8 Kapitel 2 Cytologie der Bakterien Optische Methoden 8 9 Eukaryote Zellstrukturen Prokaryote Zellstrukturen . 12 14 Cytoplasmatische Strukturen. 27 Färbeverfahren .
Posted in Science

Chemistry and Molecular Aspects of Drug Design and Action

Author: E. A. Rekka,P. N. Kourounakis

Publisher: CRC Press

ISBN: 9781420008272

Category: Science

Page: 384

View: 2393

An ever-increasing demand for better drugs, elevated safety standards, and economic considerations have all led to a dramatic paradigm shift in the way that drugs are being discovered and developed. Known as rational drug design, this contemporary process is defined by three main steps: the discovery of lead compounds, surgical manipulation to develop pharmacophores, and further optimization to produce the best compounds. Chemistry and Molecular Aspects of Drug Design and Action brings together an impressive collection of world-renowned pharmacochemistry scientists who are currently defining the emergence of rational drug design. Offering insight from their own specialized research, these pioneers highlight the variety of approaches being employed in this field, including those that start by considering either molecular mechanisms of drug action, or the metabolizing enzyme action occurring in the structure of a drug molecule. Another approach they explore is one that starts from the pathobiochemistry and pathophysiology of target diseases. Furthermore, the book also considers drug development that makes use of already developed compounds stored in data banks. Divided into five parts, each dedicated to various aspects of the classical medicinal chemistry approach, the text makes it easy for readers to focus on a field of specific interest. Chemical, Biochemical, and Biological Aspects of Pathophysiological Conditions Classical Medicinal Chemistry Drug Design, Chemical and Molecular Aspects of Drug Action Drug Xenobiotic Metabolism Physical Organic and Theoretical Medicinal Chemistry While each section can be studied independently, the combined material in this volume provides the most comprehensive overview available on rational drug design. This work is an invaluable resource both for those entering the field, as well as those researchers looking to build on current progress.
Posted in Science

Issues in Biological and Life Sciences Research: 2011 Edition

Author: N.A

Publisher: ScholarlyEditions

ISBN: 1464963355

Category: Science

Page: 5106

View: 6138

Issues in Biological and Life Sciences Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Biological and Life Sciences Research. The editors have built Issues in Biological and Life Sciences Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biological and Life Sciences Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Biological and Life Sciences Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Posted in Science

Cumulated Index Medicus

Author: N.A

Publisher: N.A

ISBN: N.A

Category: Medicine

Page: N.A

View: 717

Posted in Medicine

Psychopharmacology Bulletin

Author: N.A

Publisher: N.A

ISBN: N.A

Category: Psychopharmacology

Page: N.A

View: 6165

Issues for 1974- include the section: Psychopharmacology--a recurring bibliography.
Posted in Psychopharmacology

Methodenlehre der Sozialwissenschaften

Author: Felix Kaufmann

Publisher: Springer-Verlag

ISBN: 3709160014

Category: History

Page: N.A

View: 763

Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen für die historische wie auch die disziplingeschichtliche Forschung zur Verfügung, die jeweils im historischen Kontext betrachtet werden müssen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.
Posted in History

Experimentelle Urologie

Author: Rolf Harzmann,Günther Jacobi,Lothar Weissbach

Publisher: Springer-Verlag

ISBN: 3642705243

Category: Medical

Page: 516

View: 5868

Anliegen dieses Buches ist es, die wichtigsten Aktivitäten auf dem Gebiet der experimentellen Urologie und aller in die Urologie hineinwirkenden Disziplinen darzustellen. Aus vergleichsweise bescheidenen Anfängen hat sich innerhalb von 12 Jahren ein Forum entwickelt, das an Eigenständigkeit und Vitalität nichts vermissen läßt und dessen weitere Entwicklung zu verfolgen loh nend erscheint. Der ursprüngliche Ansatz, eine Plattform für die Vorstel lung neuer diagnostischer und therapeutischer Konzepte, die Fortschritte für die Urologie versprechen, zu schaffen, blieb unverändert erhalten. So mit bildet die Innovation bei Wahrung des klinischen Bezugs den Schwer punkt dieses Buches. Da Niveau und Resonanz der im Abstand von jeweils zwei Jahren stattfindenden Tagungen ständig gestiegen sind und sich darüber hinaus auch internationale Kontakte abzeichnen, ist geplant, die Ergebnisse künf tig in einer in regelmäßigen Abständen erscheinenden Buchreihe zu publi zieren. Dem Springer-Verlag - und hier in erster. Linie Herrn Bergstedt - sei an dieser Stelle für die ausgezeichnete Betreuung des Buchprojektes ge dankt.
Posted in Medical