Sigma Receptors

Chemistry, Cell Biology and Clinical Implications

Author: Rae R. Matsumoto,Wayne D. Bowen,Tsung Ping Su

Publisher: Springer Science & Business Media

ISBN: 0387365141

Category: Medical

Page: 413

View: 9640

This book provides an update on sigma receptors, and summarizes recent advances in the medicinal chemistry, molecular biology, and cell biology of sigma receptors. It describes the functional effects mediated by these receptors and the potential clinical implications of these actions. The information is put in a historical perspective. This provides a launching point from which future studies and research directions can easily be developed.
Posted in Medical

The Opiate Receptors

Author: Gavril W. Pasternak

Publisher: Springer Science & Business Media

ISBN: 9781607619932

Category: Medical

Page: 516

View: 7931

This new edition covers the latest knowledge on opiate receptors and related receptor subtypes. It discusses many topics pertaining to the unique integrated approach of correlating the biochemical, physiological and pharmacological aspects of opiate reaction.
Posted in Medical

Sigma Receptors: Their Role in Disease and as Therapeutic Targets

Author: Sylvia B. Smith,Tsung-Ping Su

Publisher: Springer

ISBN: 3319501747

Category: Medical

Page: 312

View: 2853

Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types. It’s putative role in degenerative neuronal diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, pain, drug addiction and locomotor activity. Their roles in possible treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors. Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein.
Posted in Medical

Sigma Receptors

Author: Yossef Itzhak

Publisher: N.A

ISBN: N.A

Category: Medical

Page: 340

View: 991

This is the 12th in the Neuroscience Perspectives Series. The existence of sigma receptors in the central nervous system has only relatively recently been established. In line with the aims of Neuroscience Perspectives, this volume will cover the historical background of the subject, together with the physiological, molecular biological and pharmacological aspects, with a discussion on the concept of sigma receptors subtypes and their postulated relevance for CNS disorders.
Posted in Medical

Biochemical studies on the sigma-1 receptor

a multidrug binding protein of enigmatic function

Author: Subramaniam Ramachandran,The University of Wisconsin - Madison

Publisher: ProQuest

ISBN: N.A

Category:

Page: 220

View: 4583

The data and findings presented in this thesis area contribute towards understanding the biology of the sigma-1 receptor. The pure sigma-1 receptor is a useful tool that for biochemical and structural experiments which were previously not possible. The work presented here also places sphingosine in the list of possible sigma-1 receptor endogenous ligands. Studies with the K+ channel have uncovered a broader role for sigma ligands in modulating channel regulation.
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Cancer Research

Author: N.A

Publisher: N.A

ISBN: N.A

Category: Cancer

Page: N.A

View: 3366

Posted in Cancer

Receptor Chemistry Towards the Third Millennium

Author: M. Gianella,G. Marucci,W. Quaglia,U. Gulini

Publisher: Elsevier

ISBN: 9780080540405

Category: Science

Page: 280

View: 8645

Receptor Chemistry Towards the Third Millennium is the result of papers presented at the 12th Camerino-Noordwijkerhout Symposium, held in Camerino, Italy in September 1999. Although much is known about the way ligands interact with receptors, which have now been isolated, characterized and cloned, many aspects still remain to be explored. In particular, differentiation into distinct subpopulations and the multiplicity of transduction processes offer more specific targets in the search for new drugs. This book will be of interest to medicinal chemists, pharmacologists, biochemists and neurologists and will also be a valuable source of reference for medical students and postgraduate students in related fields.
Posted in Science

Delivery Technologies for Biopharmaceuticals

Peptides, Proteins, Nucleic Acids and Vaccines

Author: Lene Jorgensen,Hanne Morck Nielson

Publisher: John Wiley & Sons

ISBN: 0470688408

Category: Science

Page: 442

View: 4518

Advances in biotechnology have provided scientists with anincreasing number of biopharmaceuticals such as novel peptide andprotein drugs as well as nucleic acid based drugs for gene therapy.However, successful delivery of these biopharmaceuticals is a majorchallenge because their molecular properties lead to poor physicaland chemical stability in the body and limited membranepermeability. Therefore researchers are developing a range of newdelivery technologies and materials to enable these new drugs to bedelivered intact to their target sites. Delivery Technologies forBiopharmaceuticals describes strategies to overcome themain barriers for successful delivery of therapeutic peptides,proteins, and nucleic acid-based drugs or vaccines related to thesite of administration and the target site. Many of the approachesdescribed are reported in formulations in current clinical trialsas well as in marketed products. Contents include: challenges in delivery of biopharmaceuticals novel formulation approaches for peptide and proteininjectables non-viral chemical vectors and viral technology for delivery ofnucleic acid based drugs immune response, adjuvants and delivery systems forvaccines several examples of delivery systems for differentbiopharmaceuticals a critical assessment of delivery technologies forbiopharmaceuticals Delivery Technologies for Biopharmaceuticals is anessential single-volume introduction to the technologies used byresearchers to ensure efficient delivery of this exciting new classof drugs. It will be of value to researchers and students workingin drug delivery, formulation, biopharmaceuticals, medicinalchemistry, and new materials development.
Posted in Science

Chemistry and Molecular Aspects of Drug Design and Action

Author: E. A. Rekka,P. N. Kourounakis

Publisher: CRC Press

ISBN: 9781420008272

Category: Science

Page: 384

View: 2616

An ever-increasing demand for better drugs, elevated safety standards, and economic considerations have all led to a dramatic paradigm shift in the way that drugs are being discovered and developed. Known as rational drug design, this contemporary process is defined by three main steps: the discovery of lead compounds, surgical manipulation to develop pharmacophores, and further optimization to produce the best compounds. Chemistry and Molecular Aspects of Drug Design and Action brings together an impressive collection of world-renowned pharmacochemistry scientists who are currently defining the emergence of rational drug design. Offering insight from their own specialized research, these pioneers highlight the variety of approaches being employed in this field, including those that start by considering either molecular mechanisms of drug action, or the metabolizing enzyme action occurring in the structure of a drug molecule. Another approach they explore is one that starts from the pathobiochemistry and pathophysiology of target diseases. Furthermore, the book also considers drug development that makes use of already developed compounds stored in data banks. Divided into five parts, each dedicated to various aspects of the classical medicinal chemistry approach, the text makes it easy for readers to focus on a field of specific interest. Chemical, Biochemical, and Biological Aspects of Pathophysiological Conditions Classical Medicinal Chemistry Drug Design, Chemical and Molecular Aspects of Drug Action Drug Xenobiotic Metabolism Physical Organic and Theoretical Medicinal Chemistry While each section can be studied independently, the combined material in this volume provides the most comprehensive overview available on rational drug design. This work is an invaluable resource both for those entering the field, as well as those researchers looking to build on current progress.
Posted in Science

Issues in Biological and Life Sciences Research: 2011 Edition

Author: N.A

Publisher: ScholarlyEditions

ISBN: 1464963355

Category: Science

Page: 5106

View: 2356

Issues in Biological and Life Sciences Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Biological and Life Sciences Research. The editors have built Issues in Biological and Life Sciences Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biological and Life Sciences Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Biological and Life Sciences Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Posted in Science

Cumulated Index Medicus

Author: N.A

Publisher: N.A

ISBN: N.A

Category: Medicine

Page: N.A

View: 5214

Posted in Medicine

Psychopharmacology Bulletin

Author: N.A

Publisher: N.A

ISBN: N.A

Category: Psychopharmacology

Page: N.A

View: 7280

Issues for 1974- include the section: Psychopharmacology--a recurring bibliography.
Posted in Psychopharmacology

Experimentelle Urologie

Author: Rolf Harzmann,Günther Jacobi,Lothar Weissbach

Publisher: Springer-Verlag

ISBN: 3642705243

Category: Medical

Page: 516

View: 7948

Anliegen dieses Buches ist es, die wichtigsten Aktivitäten auf dem Gebiet der experimentellen Urologie und aller in die Urologie hineinwirkenden Disziplinen darzustellen. Aus vergleichsweise bescheidenen Anfängen hat sich innerhalb von 12 Jahren ein Forum entwickelt, das an Eigenständigkeit und Vitalität nichts vermissen läßt und dessen weitere Entwicklung zu verfolgen loh nend erscheint. Der ursprüngliche Ansatz, eine Plattform für die Vorstel lung neuer diagnostischer und therapeutischer Konzepte, die Fortschritte für die Urologie versprechen, zu schaffen, blieb unverändert erhalten. So mit bildet die Innovation bei Wahrung des klinischen Bezugs den Schwer punkt dieses Buches. Da Niveau und Resonanz der im Abstand von jeweils zwei Jahren stattfindenden Tagungen ständig gestiegen sind und sich darüber hinaus auch internationale Kontakte abzeichnen, ist geplant, die Ergebnisse künf tig in einer in regelmäßigen Abständen erscheinenden Buchreihe zu publi zieren. Dem Springer-Verlag - und hier in erster. Linie Herrn Bergstedt - sei an dieser Stelle für die ausgezeichnete Betreuung des Buchprojektes ge dankt.
Posted in Medical

Procalcitonin

a new, innovative infection parameter ; biochemical and clinical aspects ; 23 tables

Author: M. Meisner

Publisher: Georg Thieme Verlag

ISBN: 9783131055033

Category:

Page: 196

View: 6492

This work provides specific infection parameters for bacterial infections, and indicators for the inflammatory activity of sepsis and multi-organ failure.
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Neurowissenschaften

Eine Einführung

Author: Eric Kandel,James Schwartz,Thomas Jessell

Publisher: Spektrum Akademischer Verlag

ISBN: 9783827429056

Category: Medical

Page: 787

View: 4859

Dieses umfassende Lehrbuch für Studenten und Dozenten der Neurobiologie sowie an der Hirnforschung Interessierter aus Medizin und Psychologie ist die erste integrierende Darstellung der modernen Neurowissenschaften. Zahlreiche Disziplinen versuchen gemeinsam, menschliches Denken und Verhalten sowie deren Störungen auf biologische Strukturen und Vorgänge bzw. ihre Veränderung zurückzuführen. Der 'Kandel/Schwartz/Jessell' setzt nur (Oberstufen-)Schulwissen voraus und entwickelt aus der umfassenden Präsentation der molekularen und zellulären Grundeinheiten und -funktionen des Nervensystems geschickt das Verständnis von Wahrnehmungsprozessen, der Bewegungssteuerung und schließlich der höhreren geistigen Hirnleistungen wie Sprache, Lernen und Gedächtnis. Um das von Studierenden nachgefragte Buch auch weiterhin lieferbar halten zu können, wurde es schwarzweiß gedruckt.
Posted in Medical

Steroidhormone

Biosynthese, Stoffwechsel, Wirkung

Author: L. Träger

Publisher: Springer-Verlag

ISBN: 3642665292

Category: Science

Page: 352

View: 4528

Posted in Science