Protein Structure and Function

Author: Gregory A. Petsko,Dagmar Ringe

Publisher: New Science Press

ISBN: 1405119225

Category: Science

Page: 195

View: 8860

Each title in the 'Primers in Biology' series is constructed on a modular principle that is intended to make them easy to teach from, to learn from, and to use for reference.
Posted in Science

Proteins

Structure and Function

Author: David Whitford

Publisher: John Wiley & Sons

ISBN: 1118685725

Category: Science

Page: 520

View: 8957

Proteins: Structure and Function is a comprehensive introduction to the study of proteins and their importance to modern biochemistry. Each chapter addresses the structure and function of proteins with a definitive theme designed to enhance student understanding. Opening with a brief historical overview of the subject the book moves on to discuss the ‘building blocks’ of proteins and their respective chemical and physical properties. Later chapters explore experimental and computational methods of comparing proteins, methods of protein purification and protein folding and stability. The latest developments in the field are included and key concepts introduced in a user-friendly way to ensure that students are able to grasp the essentials before moving on to more advanced study and analysis of proteins. An invaluable resource for students of Biochemistry, Molecular Biology, Medicine and Chemistry providing a modern approach to the subject of Proteins.
Posted in Science

Fundamentals of Protein Structure and Function

Author: Engelbert Buxbaum

Publisher: Springer

ISBN: 331919920X

Category: Science

Page: 521

View: 6224

This book serves as an introduction to protein structure and function. Starting with their makeup from simple building blocks, called amino acids, the 3-dimensional structure of proteins is explained. This leads to a discussion how misfolding of proteins causes diseases like cancer, various encephalopathies, or diabetes. Enzymology and modern concepts of enzyme kinetics are then introduced, taking into account the physiological, pharmacological and medical significance of this often neglected topic. This is followed by thorough coverage of hæmoglobin and myoglobin, immunoproteins, motor proteins and movement, cell-cell interactions, molecular chaperones and chaperonins, transport of proteins to various cell compartments and solute transport across biological membranes. Proteins in the laboratory are also covered, including a detailed description of the purification and determination of proteins, as well as their characterisation for size and shape, structure and molecular interactions. The book emphasises the link between protein structure, physiological function and medical significance. This book can be used for graduate and advanced undergraduate classes covering protein structure and function and as an introductory text for researchers in protein biochemistry, molecular and cell biology, chemistry, biophysics, biomedicine and related courses. About the author: Dr. Buxbaum is a biochemist with interest in enzymology and protein science. He has been working on the biochemistry of membrane transport proteins for nearly thirty years and has taught courses in biochemistry and biomedicine at several universities.
Posted in Science

Prediction of Protein Structures, Functions, and Interactions

Author: Janusz M. Bujnicki

Publisher: John Wiley & Sons

ISBN: 9780470741900

Category: Science

Page: 302

View: 5156

The growing flood of new experimental data generated by genome sequencing has provided an impetus for the development of automated methods for predicting the functions of proteins that have been deduced by sequence analysis and lack experimental characterization. Prediction of Protein Structures, Functions and Interactions presents a comprehensive overview of methods for prediction of protein structure or function, with the emphasis on their availability and possibilities for their combined use. Methods of modeling of individual proteins, prediction of their interactions, and docking of complexes are put in the context of predicting gene ontology (biological process, molecular function, and cellular component) and discussed in the light of their contribution to the emerging field of systems biology. Topics covered include: first steps of protein sequence analysis and structure prediction automated prediction of protein function from sequence template-based prediction of three-dimensional protein structures: fold-recognition and comparative modelling template-free prediction of three-dimensional protein structures quality assessment of protein models prediction of molecular interactions: from small ligands to large protein complexes macromolecular docking integrating prediction of structure, function, and interactions Prediction of Protein Structures, Functions and Interactions focuses on the methods that have performed well in CASPs, and which are constantly developed and maintained, and are freely available to academic researchers either as web servers or programs for local installation. It is an essential guide to the newest, best methods for prediction of protein structure and functions, for researchers and advanced students working in structural bioinformatics, protein chemistry, structural biology and drug discovery.
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Introduction to Proteins

Structure, Function, and Motion, Second Edition

Author: Amit Kessel,Nir Ben-Tal

Publisher: CRC Press

ISBN: 1498747183

Category: Medical

Page: 932

View: 5732

Introduction to Proteins shows how proteins can be analyzed in multiple ways. It refers to the roles of proteins and enzymes in diverse contexts and everyday applications, including medical disorders, drugs, toxins, chemical warfare, and animal behavior. This edition includes a brand-new chapter on enzymatic catalysis and biochemistry, an in-depth discussion of G-protein-coupled receptors (GPCRs), and a wider-scale description of methods for studying proteins.
Posted in Medical

The Evolution of Protein Structure and Function

A Symposium in Honor of Professor Emil L. Smith

Author: David S. Sigman,Mary A. B. Brazier

Publisher: Elsevier

ISBN: 1483262812

Category: Science

Page: 368

View: 6712

The Evolution of Protein Structure and Function documents the proceedings of the symposium ""Evolution of Protein Structure and Function"" held at the Dickson Art Auditorium, University of California Los Angeles (UCLA), 28-29 June 1979. Its objective was to honor Professor Emil L. Smith on the occasion of his retirement as Professor and Chairman, Department of Biological Chemistry, School of Medicine, UCLA. The papers presented by Emil’s colleagues, friends, and students from all phases of his long and varied scientific career provided a valuable review of enzymology, protein chemistry, and biochemical evolution. The volume contains 16 chapters is organized into three parts. Part I contains papers on enyzmology, including the role of the recA protein of Escherichia coli in general recombination; the evolution of enzyme families; and studies on metalloenzymes. Part II takes up protein structure and function. It includes papers on glycoprotein hormones, thymus hormones, chromosome biology and chemistry, and the evolution of histones. Part III examines the evolution of proteins, including the evolution of cythochrome c and evolution of phycobilisome of cyanobacteria and red algae.
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From Protein Structure to Function with Bioinformatics

Author: Daniel J. Rigden

Publisher: Springer

ISBN: 9402410694

Category: Science

Page: 503

View: 4722

This book is about protein structural bioinformatics and how it can help understand and predict protein function. It covers structure-based methods that can assign and explain protein function based on overall folds, characteristics of protein surfaces, occurrence of small 3D motifs, protein-protein interactions and on dynamic properties. Such methods help extract maximum value from new experimental structures, but can often be applied to protein models. The book also, therefore, provides comprehensive coverage of methods for predicting or inferring protein structure, covering all structural classes from globular proteins and their membrane-resident counterparts to amyloid structures and intrinsically disordered proteins. The book is split into two broad sections, the first covering methods to generate or infer protein structure, the second dealing with structure-based function annotation. Each chapter is written by world experts in the field. The first section covers methods ranging from traditional homology modelling and fold recognition to fragment-based ab initio methods, and includes a chapter, new for the second edition, on structure prediction using evolutionary covariance. Membrane proteins and intrinsically disordered proteins are each assigned chapters, while two new chapters deal with amyloid structures and means to predict modes of protein-protein interaction. The second section includes chapters covering functional diversity within protein folds and means to assign function based on surface properties and recurring motifs. Further chapters cover the key roles of protein dynamics in protein function and use of automated servers for function inference. The book concludes with two chapters covering case studies of structure prediction, based respectively on crystal structures and protein models, providing numerous examples of real-world usage of the methods mentioned previously. This book is targeted at postgraduate students and academic researchers. It is most obviously of interest to protein bioinformaticians and structural biologists, but should also serve as a guide to biologists more broadly by highlighting the insights that structural bioinformatics can provide into proteins of their interest.
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Proteins

Structure and Function

Author: James J. L'Italien

Publisher: Springer

ISBN: N.A

Category: Science

Page: 817

View: 9633

This volume surveys the current status of many of the important methods and approaches which are central to the study of protein structure and function. Many of the articles in this volume are written to emphasize the general utility of the method or approach which is at its core, and to provide sufficient literature references to enable the reader to adapt the method or approach to other applications. It is hoped that this volume will provide a source from which newcomers as well as experienced scient ists may becom& more familiar with recent developments and future trends in some of the important areas of protein research. The articles which comprise this book are selected proceedings from the Symposium of American Protein Chemists, which was held in San Diego, California, September 30 to October 3, 1985. The goal of the organizers of this first symposium was to provide a forum for discussion and inter action among scientists whose interests span the broad spectrum of protein structure and function research. The concept and timing of the symposium well received as evidenced by the approximately 500 delegates to the was symposium. The inaugural meeting was marked by a strong scientific pro gram with over 140 papers presented in either a lecture or poster format.
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Structure and Function of Intrinsically Disordered Proteins

Author: Peter Tompa,Alan Fersht

Publisher: CRC Press

ISBN: 9781420078930

Category: Science

Page: 359

View: 7704

The existence and functioning of intrinsically disordered proteins (IDPs) challenge the classical structure-function paradigm that equates function with a well-defined 3D structure. Uncovering the disordered complement of proteomes and understanding their functioning can extend the structure-function paradigm to herald new breakthroughs in drug development. Structure and Function of Intrinsically Disordered Proteins thoroughly covers the history up to the latest developments in this field. After examining the principles of protein structure, the classical paradigm, and the history of structural disorder, the book focuses on physical techniques for the identification and characterization of IDPs. It discusses proteomic and bioinformatic approaches and shows how IDPs behave under crowding conditions in living cells. The next several chapters describe the structure, correlating biological processes, and molecular mechanisms of IDPs. The author also explores the evolutionary advancement of structural disorder in proteomes and possible ways of extending the structure-function paradigm to encompass both ordered and disordered states of proteins. He concludes with discussions on the involvement of IDPs in various diseases and how to establish rational drug design through detailed characterization of IDPs. Although drug discovery rates have leveled off, new insight generated by the study of IDPs may offer fresh strategies for drug development. This work illustrates how these proteins defy the structure-function paradigm and play important regulatory and signaling roles.
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Proteins: Structure, Function, and Engineering

Author: B.B. Biswas,Siddhartha Roy

Publisher: Springer Science & Business Media

ISBN: 1489917276

Category: Science

Page: 436

View: 598

Here, researchers review the latest breakthroughs in protein research. Their contributions explore emerging principles and techniques and survey important classes of proteins that will play key roles in the field's future. Articles examine the possibility of a Boltzman-like distribution in protein substructures, the new technique of Raman spectroscopy, and compact intermediate states of protein folding. This well-illustrated volume also features coverage of proteins that bind nucleic acids.
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Human Blood Plasma Proteins

Structure and Function

Author: Johann Schaller,Simon Gerber,Urs Kaempfer,Sofia Lejon,Christian Trachsel

Publisher: John Wiley & Sons

ISBN: 9780470724361

Category: Science

Page: 538

View: 9913

Human Blood Plasma Proteins gives an overview of the proteins found in human blood plasma, with special emphasis on their structure and function and relationship to pathological states and disease. Topics covered include: introduction to blood components and blood plasma proteins blood plasma protein domains, motifs and repeats blood plasma protein families and posttranslational modifications blood coagulation and fibrinolysis the complement system the immune system enzymes inhibitors lipoproteins hormones cytokines and growth factors transport and storage The information of each protein discussed in this book in some detail is summarised at the end of each chapter in a Data Sheet, where one can find the most important data of each protein at one glance. Full cross-referencing to protein databases is given and many of the proteins discussed are accompanied by their 3D structure. Attractively presented in full colour, Human Blood Plasma Proteins is an essential atlas of this proteome for anyone working in biochemistry, protein chemistry and proteomics, structural biology, and medicine.
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Protein Structure

Determination, Analysis, and Applications for Drug Discovery

Author: Daniel Chasman

Publisher: CRC Press

ISBN: 0824748166

Category: Medical

Page: 576

View: 6421

This text offers in-depth perspectives on every aspect of protein structure identification, assessment, characterization, and utilization, for a clear understanding of the diversity of protein shapes, variations in protein function, and structure-based drug design. The authors cover numerous high-throughput technologies as well as computational methods to study protein structures and residues. A valuable reference, this book reflects current trends in the effort to solve new structures arising from genome initiatives, details methods to detect and identify errors in the prediction of protein structural models, and outlines challenges in the conversion of routine processes into high-throughput platforms.
Posted in Medical

Protein structure

Author: N. J. Darby,Thomas E. Creighton

Publisher: Oxford University Press, USA

ISBN: N.A

Category: Literary Criticism

Page: 99

View: 1277

Proteins play a central role in all biological systems. They fulfill numerous functions which depend upon their complex three-dimensional structures, maintained by a multitude of interactions. This book examines important advances in the understanding of protein structure diversity, the basis of protein stability, and the important relationship between structure and function. These findings have been made possible through the application of key techniques such as X-ray crystallography, NMR, and protein engineering. Protein Structure: In Focus provides comprehensive coverage of this subject for students in biochemistry, biophysics, molecular biology, and related courses, and will also be of great interest to researchers requiring an introduction to this field.
Posted in Literary Criticism

The Proteins Composition, Structure, and Function

Author: Hans Neurath

Publisher: Elsevier

ISBN: 0323161618

Category: Science

Page: 526

View: 5732

The Proteins: Composition, Structure, and Function, Second Edition, Volume IV covers the significant developments in understanding the relationships between the composition, structure, and function of proteins. This three-chapter volume deals first with the genetic determination of protein structure and with the effects of mutational alteration on the structure and function of proteins. A highly relevant aspect of this topic is the change in protein structure during evolution and cell development. The second chapter describes the basic structure of several glycoproteins, such as orosomucoid, egg albumin, and submaxillary gland glycoprotein. The third chapter highlights the features of composition and arrangement of the group protein, which impart the capacity to perform their physical function. This book is of value to organic chemists, biochemists, and researchers in the protein-related fields.
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Membrane Protein Structure and Function Characterization

Methods and Protocols

Author: Jean-Jacques Lacapere

Publisher: Humana Press

ISBN: 9781493971497

Category: Science

Page: 419

View: 6586

In this present volume, different approaches are detailed to produce membrane proteins, purify them, study their function, determine their structure, and model them in membrane. Since every membrane protein behaves mostly in a unique way /fashion, knowledge of guidelines and tricks may help to increase chances to express, purify and characterize a peculiar membrane protein. Production of correctly folded protein remains a challenge. Moreover, getting a functional and stable protein requires to optimize membrane mimicking environments that can be detergent or artificial membranes. In some cases, the finding of the correct ligand which will stabilize the desired conformation is needed. In other cases, stabilization can be obtained using specific antibodies. This volume also presents different techniques to analyze the functional status of membrane proteins. Written in the highly successful Methods in Molecular Biology series format, chapters in Membrane Protein Structure and Function Characterization: Methods and Protocols provide different techniques to analyze the functional and structural status of membrane proteins. Chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Membrane Protein Structure and Function Characterization: Methods and Protocols aims to ensure successful results in the further study of this vital field.
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Protein Structure — Function Relationship

Author: D.L. Smith,Z.H. Zaidi

Publisher: Springer Science & Business Media

ISBN: 1461303591

Category: Science

Page: 309

View: 7375

Although many pursue understanding of the relationship between protein structure and function for the thrill of pure science, the pay-off in a much broader sense is the ability to manipulate the Earth's chemistry and biology to improve the quality of life for mankind. Immediately goals of this area of research include identification of the life-supporting functions of proteins, and the fundamental forces that facilitate these functions. Upon reaching these goals, we shall have the understanding to direct and the tools required to implement changes that will dramatically improve the quality of life. For example, under standing the chemical mechanism of diseases will facilitate development of new therapeutic drugs. Likewise, understanding of chemical mechanisms of plant growth will be used with biotechnology to improve food production under adverse climatic conditions. The challenge to understand details of protein structure/function relationships is enormous and requires an international effort for success. To direct the chemistry and biology of our environment in a positive sense will require efforts from bright, imaginative scientists located throughout the world. Although the emergence of FAX, e-mail, and the World Wide Web has revolutionized international communication, there remains a need for scientists located in distant parts of the world to occasionally meet face to face.
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Proteins: structure and function

Author: Masaru Funatsu

Publisher: Halsted Press

ISBN: N.A

Category: Science

Page: 270

View: 3460

Posted in Science

Protein Families

Relating Protein Sequence, Structure, and Function

Author: Christine A. Orengo,Alex Bateman

Publisher: John Wiley & Sons

ISBN: 1118742818

Category: Computers

Page: 536

View: 1391

New insights into the evolution and nature of proteins Exploring several distinct approaches, this book describes themethods for comparing protein sequences and protein structures inorder to identify homologous relationships and classify proteinsand protein domains into evolutionary families. Readers willdiscover the common features as well as the key philosophicaldifferences underlying the major protein classification systems,including Pfam, Panther, SCOP, and CATH. Moreover, they'll discoverhow these systems can be used to understand the evolution ofprotein families as well as understand and predict the degree towhich structural and functional information are shared betweenrelatives in a protein family. Edited and authored by leading international experts, ProteinFamilies offers new insights into protein families that areimportant to medical research as well as protein families that helpus understand biological systems and key biological processes suchas cell signaling and the immune response. The book is divided intothree sections: Section I: Concepts Underlying Protein FamilyClassification reviews the major strategies for identifyinghomologous proteins and classifying them into families. Section II: In-Depth Reviews of Protein Families focuseson some fascinating super protein families for which we havesubstantial amounts of sequence, structural and functional data,making it possible to trace the emergence of functionally diverserelatives. Section III: Review of Protein Families in ImportantBiological Systems examines protein families associated with aparticular biological theme, such as the cytoskeleton. All chapters are extensively illustrated, including depictionsof evolutionary relationships. References at the end of eachchapter guide readers to original research papers and reviews inthe field. Covering protein family classification systems alongsidedetailed descriptions of select protein families, this book offersbiochemists, molecular biologists, protein scientists, structuralbiologists, and bioinformaticians new insight into the evolutionand nature of proteins.
Posted in Computers

Structure and Function of Cholinesterases and Related Proteins

Author: Bhupendra P. Doctor,Palmer Taylor,Daniel M. Quinn,Richard L. Rotundo,Mary Kay Gentry

Publisher: Springer Science & Business Media

ISBN: 1489915400

Category: Medical

Page: 630

View: 4478

The Sixth International Meeting on Cholinesterases and Related Proteins, Choli nesterases '98, was organized by Palmer Taylor and his associates at the University of California-San Diego and convened in La Jolla, California, USA, in March of 1998. This was the first conference of the series to be held in the United States, let alone on the Pa cific Rim. Nearly 200 delegates from twenty countries-from Asia, Australia, Europe, and North and South America-heard 75 oral presentations and viewed 90 posters on current research on cholinesterases and related proteins. The meeting framework was structured to include two days of plenary sessions, followed by two days of concurrent sessions and workshops in specific areas. Communication at the concurrent sessions was facilitated by the conference settings of the Martin Johnson House, on a scenic bluff overlooking the blue Pacific Ocean, and the San Diego Supercomputer Center, which enabled projection and rotation of protein structures in three dimensions for a large audience. This book is the compilation of the presentations at the Sixth International Meeting on Cholinesterases and Related Proteins into a volume that describes recent investigations on the structure, catalytic and non-catalytic functions of acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and related proteins, as well as studies on the molecular and cellular biology of these enzymes and the genes that encode them.
Posted in Medical