Molecules and Medicine provides, for the first time ever, a completely integrated look at chemistry, biology, drug discovery, and medicine. It delves into the discovery, application, and mode of action of more than one hundred of the most significant molecules in use in modern medicine. Opening sections of the book provide a unique, clear, and concise introduction, which enables readers to understand chemical formulas.
Author: E. J. Corey,Barbara Czakó,László Kürti
Publisher: John Wiley & Sons
This core genetics text supports medical students in their first or second year. Unique in its approach, Genetics teaches concepts by exploring disease entities within the context of the organ system in which they most frequently present. Coverage of the patient and family's point of view helps students understand and anticipate the major obstacles for those living with severe genetic conditions. Top 30 genetic conditions are profiled in a special section. Content has been carefully adapted from the successful German text for the English language audience.
From Molecules to Medicine
Author: Christian Patrick Schaaf,Johannes Zschocke,Lorraine Potocki
Publisher: Lippincott Williams & Wilkins
The contributors present a coherent set of case studies of practices, technologies and strategies aimed at the isolation, investigation, manipulation, production, and uses of molecules including vitamins, hormones, blood products, antibiotics, and vaccines. These case studies examine how processes of molecularization were set in motion in the inter-war period, how they were used as a resource in the biomedical 'mobilization' of World War II, and how new alliances and strategies created as part of the war effort played a central role in the reorganisation of biomedicine in the post-war period.
New Practices and Alliances, 1920s to 1970s
Author: Soraya de Chadarevian,Harmke Kamminga
Publisher: Taylor & Francis
Molecules to Medicine with mTOR: Translating Critical Pathways into Novel Therapeutic Strategies is a one-stop reference that thoroughly covers the mechanistic target of rapamycin (mTOR). mTOR, also known as the mammalian target of rapamycin, is a 289-kDa serine/threonine protein kinase that is ubiquitous throughout the body and has a critical role in gene transcription and protein formation, stem cell development, cell survival and senescence, aging, immunity, tissue regeneration and repair, metabolism, tumorigenesis, oxidative stress, and pathways of programmed cell death that include apoptosis and autophagy. Incorporating a translational medicine approach, this important reference highlights the basic cellular biology of mTOR pathways, presents the role of mTOR during normal physiologic function and disease, and illustrates how the mechanisms of mTOR can be targeted for current and future therapeutic treatment strategies. Coverage of mTOR signaling includes the entire life cycle of cells that impacts multiple systems of the body including those of nervous, cardiovascular, immune, musculoskeletal, endocrine, reproductive, renal, and respiratory origin. Covers the role of mTOR by internationally recognized expert contributors in the field. Provides a clear picture of the complexity of mTOR signaling as well as of the different approaches that could target this pathway at various levels. Includes analysis of the role of mTOR and in both health and disease. Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings.
Translating Critical Pathways into Novel Therapeutic Strategies
Author: Kenneth Maiese
Publisher: Academic Press
A comprehensive guide to the HLA (Human Leukocyte Antigen) system for immunologists and clinicians, this book contains up-to-date information on the MHC (Major Histocompatibility Complex) and its role in the immune response and in various diseases. The book explores the biological significance and role of the HLA system in organ and haematopoietic stem cell transplantation management. This volume is an invaluable guide to the full spectrum of HLA-related science while also serving as a conceptual and technical resource for those involved in HLA-related research and in clinical or surgical practice. In addition, it will be a primary point of contact for individuals working in other areas who suddenly find that their research is drawing them into the complexities of HLA genetics.
A Resource Book
Author: Narinder K Mehra
Publisher: Boydell & Brewer Ltd
This book, a selection of the papers presented at the 2nd World Congress for Electricity and Magnetism, provides state-of-the-art information on applications of electricity and electromagnetic fields on living organisms, especially man.
Author: Ferdinando Bersani
Publisher: Springer Science & Business Media
Detecting Signals at the Single Molecule Level: Pioneering Achievements in Microscopy Recent advances have led to such remarkable improvements in fluorescence lifetime imaging microscopy’s (FLIM) capacity for contrast and sensitivity that researchers can now employ it to detect signals at the single molecule level. FLIM also offers the additional benefit of independence from fluorophore concentration and excitation intensity. Moreover, its unique sensitivity makes it an excellent reporter of conformational changes and of variations in the molecular surroundings of biological molecules. Most of this improvement and discovery have occurred during the past decade, and, to date, information that would benefit a broad range of researchers remains scattered in the literature. Edited by two of the top pioneers in the field, FLIM Microscopy in Biology and Medicine presents the fundamentals of FLIM along with a number of advanced considerations so that a wider audience can appreciate recent and potential improvements that make it such a valuable tool. New Opportunities for Biomedical Researchers... New Challenges for Microscopy Researchers Discussion sections in all the chapters clearly show the challenges for implementing FLIM for various applications. Certain chapters discuss limits on the number of photons required for highly accurate lifetime determinations, as well as the accuracy with which multiple, closely associated lifetime components can reliably be determined. Such considerations are important for the user when he or she is selecting the most advantageous method of FLIM to use for a particular application. While this book provides an introduction for those new to FLIM, it gathers a wealth of material to enhance the work of experts involved in pioneering technological improvements, as well as those research opportunities in this unique and promising area of microscopy.
Author: Ammasi Periasamy,Robert M. Clegg
Publisher: CRC Press
The dictionary is designed to be a pocket companion, for ready access by students, postgraduates, trainers, and health professionals involved in sport and exercise. It provides definitions and short accounts of terms used and techniques employed in the study and practical application of the relevant anatomy, physiology, biomechanics and psychology, and of commonly associated medical problems and treatments. Illustrations are included in the A-Z text, and appendices provide additional reference information and sources for further study. Wide coverage in A-Z text of relevant basic and applied topics relevant to sport and exercise. Full contact information for professional associations. Illustrations, graphs and tables. Team of expert contributors.
Author: Sheila Jennett
Publisher: Elsevier Health Sciences
Publisher: National Academies
Many students now begin life and medical science degrees with far less knowledge of chemistry than they need - and they struggle as a result. Catch Up Chemistry brings students up to speed with the subject quickly and easily. The book puts the essential chemistry into real biological context and is written in an extremely student-friendly manner: the text is concise and to the point; the equations are clearly laid out and explained. Key Features: •Provides all the core chemistry required for a medical sciences degree •Numerous examples to demonstrate the relevance to biology and medicine •Test Yourself questions at the end of each chapter to help the reader practise what they have learned •Student-friendly format and price
For the Life and Medical Sciences
Author: Mitch Fry,Elizabeth Page
Volume 1 of the series Changing the Global Approach to Medicine introduced the concept of RNA Vector Therapy, the innovative utilization of virus-like devices to deliver RNA molecules to protein deficient cells to provide a directed medical therapy. Volume 2 greatly expands this approach to configuring enhanced virus-like transport devices to deliver various forms of therapeutic materials to specific cell types. Medial Vector Therapy includes the delivery of DNA, chemotherapy and other drug molecules, oxygen, and nutrients as well as various forms of RNA to the cells that require such therapeutic interventions. This ingenious new approach to the management of challenging diseases has the distinct advantage of administering a broad spectrum of therapeutic elements directly to the cells in need, but dramatically limits the side effects by not exposing other cells in the body to the potential harmful effects of such therapies. Also introduced in this text are the innovative concepts the Quantum Gene and the Quadsistor.
Medical Vector Therapy
Author: Lane B. Scheiber II,Lane B. Scheiber
Several years have passed since the sequencing of the human genome and what might be called "the post-genomic era" has begun. Of course, there are many different genomes and the term "post-genomic" does not necessarily imply the human genome. However, it is the data encoded in the human genome that hold the promise to be of practical importance in a wide range of biomedical applications. The sequencing and preliminary annotations of the human genome provided an incredible amount of the raw, largely unprocessed information. Coupled with the millions of publications on human physiology already available in public databases, it is clear that certain informational strategies should be adopted for the retrieval, analysis and representation of these data. Among biological sciences, bioinformatics is a specific branch that deals with managing complexities in the biological information. However, the bioinformatics is in no way restricted to the compilation of large databases or elaboration of sophisticated software. The methods of bioinformatics can greatly assist the generation of productive hypotheses that allow subsequent experimental testing followed by confirmation or disapproval. The main idea behind the present volume is not worrying about the steadily growing amounts of biomedical information or about the relative quality of it. This volume, as well as the entire book series, is based on the purpose-oriented attitude: how to make a good use of this information in particular research projects.
Author: Ivan Y. Torshin
Publisher: Nova Publishers
Andrew Thompson, Norman J. Temple We humans are an extraordinary species. One of our finest achievements is the development of morality, of a sense of right and wrong. We articulate and then impose this sensitivity upon ourselves in the form of ethical guidelines, rules, regulations, and laws. We have, regrettably, also developed marvelously clever ways of justifying our behavior whenever it runs afoul of these prescriptions. We have, for example, developed the concept of objectivity to guide scientific pursuits and subsequently established rights which undermine the possibility of ever coming close to attaining the goal of being objective -- rights which entitle participating scientists to gain personal, tangible profits from scientific discoveries. Formerly, we envisaged gods who kept us in place, who reminded us that we were not all-powerful or especially wise. Now we tend to worship our achievements, especially our technological ones, and ourselves. Mary Midgley' aptly names this phenomenon, "humanolatry." We have lost our respect for nature in our enthusiasm for changing it to that which suits our shortsighted ends. We must, as she says, "unlearn" this way of thinking.
Commercialism versus Environmentalism and Social Justice
Author: Andrew Thompson,Iqbal S. Shergill,N. Temple
Publisher: Springer Science & Business Media
The book will provide an overview of the roles of vascular adhesion molecules in health and disease, with chapters on their cell biology, followed by chapters reviewing their importance in specific disease processes. Vascular adhesion molecules are vital for the physiological processes of leukocyte trafficking and also critically involved in the enhanced leukocyte emigration that is a key feature of all inflammatory and immune diseases. The book is designed to provide up-to-date, linked reviews of the subject suitable for postgraduate students entering the field or research workers from allied disciplines needing a modern overview.
Author: Jeremy D. Pearson
an encomium for Linus Pauling
Author: Zvonimir B. Maksić,Mirjana Eckert-Maksić,Linus Pauling
Publisher: Ellis Horwood Ltd
This first entry-level guide to the multifaceted field takes readers one step further than existing textbooks. In an easily accessible manner, the authors integrate the biochemistry, cell biology and medical implications of intracellular redox processes, demonstrating that complex science can be presented in a clear and almost entertaining way. Perfect for students and junior researchers, this is an equally valuable addition to courses in biochemistry, molecular biology, cell biology, and human physiology.
Author: Claus Jacob,Paul G. Winyard
Publisher: John Wiley & Sons
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Author: Ruth Porter
Publisher: John Wiley & Sons