Molecules and Medicine

Author: E. J. Corey,Barbara Czakó,L?szl? K?rti

Publisher: John Wiley & Sons

ISBN: 1118361733

Category: Science

Page: 272

View: 7097

Molecules and Medicine provides, for the first time ever, a completely integrated look at chemistry, biology, drug discovery, and medicine. It delves into the discovery, application, and mode of action of more than one hundred of the most significant molecules in use in modern medicine. Opening sections of the book provide a unique, clear, and concise introduction, which enables readers to understand chemical formulas.
Posted in Science

Molecules and Medicine

Author: E. J. Corey,Barbara Czakó,László Kürti

Publisher: John Wiley & Sons

ISBN: 1118361695

Category: Science

Page: 272

View: 4600

Posted in Science

Molecules and Medicine

Author: E. J. Corey,Barbara Czakó,László Kürti

Publisher: Wiley


Category: Medical

Page: 254

View: 9441

Molecules and Medicine provides, for the first time ever, a completely integrated look at chemistry, biology, drug discovery, and medicine. Beautifully illustrated and presented in full colour, this book delves into the discovery, application, and mode of action of more than one hundred of the most significant molecules now used in modern medicine. With focus on the most important and commonly used medicines such as anti-clotting agents, antibiotics, Viagra and anti-malarial and antidepressant drugs, coverage includes the condition it treats, the summary of its industrial development, the year put into practice, the biological target for the medicine, the human proteins related to the disease, the metabolism or action of the condition treated, and interacting side effects and related drugs. Diagrams revealing the shape and structure of molecular make-up for each medicine accompany the text. Interspersed where appropriate, can be found background sections such as a brief survey of immunology, to help guide the readers understanding.
Posted in Medical

Molecules Of Emotion

Why You Feel The Way You Feel

Author: Candace Pert

Publisher: Simon and Schuster

ISBN: 1471109704

Category: Science

Page: 384

View: 5069

Why do we feel the way we feel? How do our thoughts and emotions affect our health? Are our bodies and minds distinct from each other or do they function together as part of an interconnected system? In MOLECULES OF EMOTION, neuroscientist Candace Pert provides startling and decisive answers to these long-debated questions, establishing the biomolecular basis for our emotions and explaining these new scientific developments in a clear and accessible way. Her pioneering research on how the chemicals inside us form a dynamic information network, linking mind and body, is not only provocative, it is revolutionary. In her groundbreaking book, Candace Pert offers a new scientific understanding of the power of our minds and our feelings to affect our health and well-being.
Posted in Science

Molecules of Death

Author: Rosemary H. Waring,Glyn B. Steventon,Steve C. Mitchell

Publisher: Imperial College Press

ISBN: 1860948146

Category: Medical

Page: 430

View: 1010

This book has been developed over many years from several popular courses taught to students at both Birmingham and London universities. It provides an important step in introducing principles and concepts within the field of toxicology. The underlying mechanisms of toxicity are highlighted through examples taken from gases, minerals, plants, fungi, bacteria, marine creatures, industrial chemicals and pharmacological agents.In this second edition, the text has been completely revised and expanded with the addition of six new chapters ? carbon monoxide, hydrofluoric acid, lead, mushroom, toxins, paracetamol, paraquat and diquat. Each chapter is self-sufficient, enabling readers to dip into chapters of interest at random without any lack of understanding. The book is informative, with numerous clinical details, and will appeal to those who wish to delve into this fascinating subject.
Posted in Medical

Bioactive Molecules and Medicinal Plants

Author: Kishan Gopal Ramawat,Jean-Michel Mérillon

Publisher: Springer Science & Business Media

ISBN: 354074603X

Category: Science

Page: 379

View: 1908

This book on medicinal plant biotechnology covers recent developments in this field. It includes a comprehensive up-to-date survey on established medicinal plants and on molecules which gained importance in recent years. No recently published book has covered these carefully selected topics. The contributing scientists have been selected on the basis of their involvement in the related plant material as evident by their internationally recognised published work.
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Molecules of Murder

Criminal Molecules and Classic Cases

Author: John Emsley

Publisher: Royal Society of Chemistry

ISBN: 1782627995

Category: Science

Page: 252

View: 4343

Molecules of Murder is about infamous murderers and famous victims; about people like Harold Shipman, Alexander Litvinenko, Adelaide Bartlett, and Georgi Markov. Few books on poisons analyse these crimes from the viewpoint of the poison itself, doing so throws a new light on how the murders or attempted murders were carried out and ultimately how the perpetrators were uncovered and brought to justice. Part I includes molecules which occur naturally and were originally used by doctors before becoming notorious as murder weapons. Part II deals with unnatural molecules, mainly man-made, and they too have been dangerously misused in famous crimes. The book ends with the most famous poisoning case in recent years, that of Alexander Litvinenko and his death from polonium chloride. The first half of each chapter starts by looking at the target molecule itself, its discovery, its history, its chemistry, its use in medicine, its toxicology, and its effects on the human body. The second half then investigates a famous murder case and reveals the modus operandi of the poisoner and how some were caught, some are still at large, and some literally got away with murder. Molecules of Murder will explain how forensic chemists have developed cunning ways to detect minute traces of dangerous substances, and explain why some of these poisons, which appear so life-threatening, are now being researched as possible life-savers. Award winning science writer John Emsley has assembled another group of true crime and chemistry stories to rival those of his highly acclaimed Elements of Murder.
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More Molecules of Murder

Author: John Emsley

Publisher: Royal Society of Chemistry

ISBN: 1788011031

Category: Law

Page: 272

View: 1391

How can a plant as beautiful as the foxglove be so deadly and yet for more than a century be used to treat heart disease? The same is true of other naturally occurring molecules as will be revealed in this current book by award-winning author and chemist, John Emsley. More Molecules of Murder follows on from his highly-acclaimed earlier book Molecules of Murder, and again it deals with 14 potential poisons; seven of which are man-made and seven of which are natural. It investigates the crimes committed with them, not from the point of view of the murderers, their victims, or the detectives, but from the poison used. In so doing it throws new light on how these crimes were carried out and ultimately how the perpetrators were uncovered and brought to justice. Each chapter starts by looking at the target molecule itself, its discovery, its chemistry, its often-surprising use in medicine, its effects on the human body, and its toxicology. The rest of the chapter is devoted to murders and attempted murders in which it has been used. But, be reassured that murder by poison is not the threat it once was, thanks to laws which restrict access to such materials and to the skills of analytical chemists in detecting their presence in incredibly tiny amounts.
Posted in Law

Pharmaceutical Analysis for Small Molecules

Author: Behnam Davani

Publisher: John Wiley & Sons

ISBN: 1119425018

Category: Science

Page: 256

View: 8576

A comprehensive introduction for scientists engaged in new drug development, analysis, and approvals Each year the pharmaceutical industry worldwide recruits thousands of recent science graduates—especially chemistry, analytical chemistry, pharmacy, and pharmaceutical majors—into its ranks. However, because of their limited background in pharmaceutical analysis most of those new recruits find making the transition from academia to industry very difficult. Designed to assist both recent graduates, as well as experienced chemists or scientists with limited regulatory, compendial or pharmaceutical analysis background, make that transition, Pharmaceutical Analysis for Small Molecules is a concise, yet comprehensive introduction to the drug development process and analysis of chemically synthesized, small molecule drugs. It features contributions by distinguished experts in the field, including editor and author, Dr. Behnam Davani, an analytical chemist with decades of technical management and teaching experience in compendial, regulatory, and industry. This book provides an introduction to pharmaceutical analysis for small molecules (non-biologics) using commonly used techniques for drug characterization and performance tests. The driving force for industry to perform pharmaceutical analyses is submission of such data and supporting documents to regulatory bodies for drug approval in order to market their products. In addition, related required supporting studies including good laboratory/documentation practices including analytical instrument qualification are highlighted in this book. Topics covered include: Drug Approval Process and Regulatory Requirements (private standards) Pharmacopeias and Compendial Approval Process (public standards) Common methods in pharmaceutical analysis (typically compendial) Common Calculations for assays and impurities and other specific tests Analytical Method Validation, Verification, Transfer Specifications including how to handle out of specification (OOS) and out of trend (OOT) Impurities including organic, inorganic, residual solvents and elemental impurities Good Documentation Practices for regulatory environment Management of Analytical Laboratories Analytical Instrument Qualifications including IQ, OQ, PQ and VQ Due to global nature of pharmaceutical industry, other topics on both regulatory (ICH) and Compendial harmonization are also highlighted. Pharmaceutical Analysis for Small Molecules is a valuable working resource for scientists directly or indirectly involved with the drug development process, including analytical chemists, pharmaceutical scientists, pharmacists, and quality control/quality assurance professionals. It also is an excellent text/reference for graduate students in analytical chemistry, pharmacy, pharmaceutical and regulatory sciences.
Posted in Science

Molecules to Medicine with mTOR

Translating Critical Pathways into Novel Therapeutic Strategies

Author: Kenneth Maiese

Publisher: Academic Press

ISBN: 012802755X

Category: Medical

Page: 472

View: 2847

Molecules to Medicine with mTOR: Translating Critical Pathways into Novel Therapeutic Strategies is a one-stop reference that thoroughly covers the mechanistic target of rapamycin (mTOR). mTOR, also known as the mammalian target of rapamycin, is a 289-kDa serine/threonine protein kinase that is ubiquitous throughout the body and has a critical role in gene transcription and protein formation, stem cell development, cell survival and senescence, aging, immunity, tissue regeneration and repair, metabolism, tumorigenesis, oxidative stress, and pathways of programmed cell death that include apoptosis and autophagy. Incorporating a translational medicine approach, this important reference highlights the basic cellular biology of mTOR pathways, presents the role of mTOR during normal physiologic function and disease, and illustrates how the mechanisms of mTOR can be targeted for current and future therapeutic treatment strategies. Coverage of mTOR signaling includes the entire life cycle of cells that impacts multiple systems of the body including those of nervous, cardiovascular, immune, musculoskeletal, endocrine, reproductive, renal, and respiratory origin. Covers the role of mTOR by internationally recognized expert contributors in the field. Provides a clear picture of the complexity of mTOR signaling as well as of the different approaches that could target this pathway at various levels. Includes analysis of the role of mTOR and in both health and disease. Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings.
Posted in Medical

Solvation Effects on Molecules and Biomolecules

Computational Methods and Applications

Author: Sylvio Canuto

Publisher: Springer Science & Business Media

ISBN: 9781402082702

Category: Science

Page: 500

View: 9639

This volume is an interdisciplinary treatise on the theoretical approach to solvation problems. It describes the essential details of the theoretical methods and places them into the context of modern applications, and hence is of broad interest to theoreticians and experimentalists. The assembly of these modern methods and applications into one volume is a unique contribution to date and gives a broad and ample description of the field in its present stage of development.
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Molecules That Changed the World

Author: K. C. Nicolaou,Tamsyn Montagnon

Publisher: Wiley-VCH

ISBN: 9783527309832

Category: Science

Page: 385

View: 4919

K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry Here, the best-selling author and renowned researcher, K. C. Nicolaou, presents around 40 natural products that all have an enormous impact on our everyday life. Printed in full color throughout with a host of pictures, this book is written in the author's very enjoyable and distinct style, such that each chapter is full of interesting and entertaining information on the facts, stories and people behind the scenes. Molecules covered span the healthy and useful, as well as the much-needed and extremely toxic, including Aspirin, urea, camphor, morphine, strychnine, penicillin, vitamin B12, Taxol, Brevetoxin and quinine. A veritable pleasure to read.
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A Taste of Molecules

In Search of the Secrets of Flavor

Author: Diane Fresquez

Publisher: The Feminist Press at CUNY

ISBN: 1558618392

Category: Science

Page: 208

View: 6412

A spirited food writer on the trail of obsessive scientists and entrepreneurs who want to titillate our taste buds.
Posted in Science

Bioactive Materials in Medicine

Design and Applications

Author: X. Zhao,J M Courtney,H Qian

Publisher: Elsevier

ISBN: 0857092936

Category: Technology & Engineering

Page: 288

View: 9716

Bioactive materials play an increasingly important role in the biomaterials industry, and are used for a range of applications, including artificial organs, drug delivery systems, nanomedicine, and biosensors. Bioactive materials in medicine reviews the current status and ongoing development of bioactive materials for medical applications. Following an introduction to bioactive materials in medicine, part one covers the process of designing bioactive materials, including chapters on molecular design, nanotechnology, and tissue engineering. Part two focuses on the different applications of bioactive materials in medicine, with chapters discussing applications in orthopaedics, in the circulatory system,and as antibacterials. The final chapters focus on the uses of these materials in gene therapy, plastic surgery and body reconstruction, and in drug delivery systems. With its distinguished editors and international team of contributors, Bioactive materials in medicine is an essential reference for researchers and designers in industry, as well as those with an academic interest in the subject. Discusses the current status and ongoing development of bioactive materials for medical applications Explores the process of designing bioactive materials, including molecular design, nanotechnology, and tissue engineering Assesses different applications of bioactive materials in medicine featuring applications in orthopaedics, in the circulatory system,and as antibacterials
Posted in Technology & Engineering

Ion Channels

Molecules in Action

Author: David J. Aidley,Peter R. Stanfield

Publisher: Cambridge University Press

ISBN: 9780521498821

Category: Medical

Page: 307

View: 879

Ion channels are crucial components of living cells. Situated in the cell membrane, they allow ions to pass from one side of the membrane to the other. This book provides an overview of ion channel study, including up-to-date coverage of the permeability and selectivity of channels, their gating and modulation, their response to drugs and toxins, and the human diseases that result from channel malfunction. Students of molecular biology, biochemistry, physiology, and neurobiology will benefit from this modern, concise text.
Posted in Medical

Magic Molecules

How Drugs Work

Author: Susan Aldridge

Publisher: Cambridge University Press

ISBN: 9780521584142

Category: Family & Relationships

Page: 269

View: 8435

All of us are drug users, in the broadest sense of the word. Drugs can be medicines, they can be used for pleasure, and they can also be used to protect our long-term health. It is important that we are well informed about the drugs we use - how they work, their benefits and their risks. This book is a unique guide for the general science reader to the drugs of everyday life - from the main types of medicine through to recreational drugs and food supplements. It looks at how drugs interact with their targets in the body, where they come from, how they are developed and what drugs to expect in the future. All the major pharmaceutical medicines are reviewed - painkillers, antibiotics, anti-cancer drugs, anti depressants, heart drugs, tranquillizers and hormones. However this book is much more than a consumer handbook - it also conveys the fascinating science of drug discovery in an easily accessible way.
Posted in Family & Relationships

Molecules in natural science and medicine

an encomium for Linus Pauling

Author: Zvonimir B. Maksić,Mirjana Eckert-Maksić,Linus Pauling

Publisher: Ellis Horwood Ltd

ISBN: 9780135615980

Category: Science

Page: 530

View: 6245

Posted in Science

The Molecules of Life

Physical and Chemical Principles

Author: John Kuriyan,Boyana Konforti,David Wemmer

Publisher: Garland Science

ISBN: 9780815341888

Category: Science

Page: 1008

View: 5660

"Key to making future advances in the areas of biochemistry and molecular medicine is a new generation of molecular biologists and biochemists who are able to harness the tools and insights of physics and chemistry to exploit the emergence of genomic and systems-level information in biology.The basic ideas of energy, entropy, equilibrium thermodynamics, transport processes and reaction kinetics are closely related to exciting issues in contemporary biology, such as protein folding, chaperones and prion diseases, DNA polymerase and ribosome fidelity, DNA recognition, drug design, signal transduction, ion channel function, motor protein action and the versatility of enzyme mechanism. Providing this physical chemistry and biochemical foundation is The "Molecules of Life," a new undergraduate textbook for undergraduate students majoring in biology or pre-med. It deepens our understanding of how life functions by illuminating the physical principles underpinning biological phenomena"--Provided by publisher.
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Molecularizing Biology and Medicine

New Practices and Alliances, 1920s to 1970s

Author: Soraya de Chadarevian,Harmke Kamminga

Publisher: Taylor & Francis

ISBN: 1135298017

Category: History

Page: 292

View: 4912

The contributors present a coherent set of case studies of practices, technologies and strategies aimed at the isolation, investigation, manipulation, production, and uses of molecules including vitamins, hormones, blood products, antibiotics, and vaccines. These case studies examine how processes of molecularization were set in motion in the inter-war period, how they were used as a resource in the biomedical 'mobilization' of World War II, and how new alliances and strategies created as part of the war effort played a central role in the reorganisation of biomedicine in the post-war period.
Posted in History

Molecular Biology of the Cell

Author: Bruce Alberts

Publisher: Garland Science

ISBN: 1317563743

Category: Science

Page: 1464

View: 9119

As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts.As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced.Protein structures better illustrate structure–function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing openended questions highlighting “What We Don’t Know,” introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text, and these problems have been expanded to all chapters by adding questions on developmental biology, tissues and stem cells, pathogens, and the immune system.
Posted in Science