Introduction to Genomics

Author: Arthur Lesk

Publisher: Oxford University Press

ISBN: 0198754833

Category:

Page: 544

View: 6358

Our genome is the blueprint for our existence: it encodes all the information we need to develop from a single cell into a hugely complicated functional organism. Yet it is more than a static information store: our genome is a dynamic, tightly-regulated collection of genes, which switch on andoff in many combinations to give the variety of cells from which our bodies are formed. But how do we identify the genes that make up our genome? How do we determine their function? And how do different genes form the regulatory networks that direct the processes of life? Introduction to Genomics is the most up-to-date and complete textbook for students approaching the subject for the first time. Lesk's engaging writing style brings a narrative to a disparate field of study and offers a fascinating insight into what can be revealed from the study of genomes. The bookcovers: the similarities and differences between organisms; how different organisms evolved; how the genome is constructed and how it operates; and what our understanding of genomics means in terms of our future health and wellbeing. The Online Resource Centre accompanying Introduction to Genomics features: For students: * Extensive and imaginative weblems (web-based problems) for each chapter designed to give you practice with the tools required for further study and research in the field* Hints and answers to end-of-chapter problems and exercises support your self-directed learning* Guided tour of websites and major archival databanks in genomics offer a wealth of resources to springboard your own research * Journal club: links to related research articles on topics covered in the book are paired with engaging questions to improve your interpretation of the primary literature* Rotating figures allow you to visualize complex structuresFor registered adopters: * Downloadable figures from the book.
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Introduction to Genomics

Author: CTI Reviews

Publisher: Cram101 Textbook Reviews

ISBN: 1467255254

Category: Education

Page: 85

View: 1081

Facts101 is your complete guide to Introduction to Genomics. In this book, you will learn topics such as Evolution and Genomic Change, Mapping, Sequencing, Annotation, and Databases, Microarrays, and Proteomics plus much more. With key features such as key terms, people and places, Facts101 gives you all the information you need to prepare for your next exam. Our practice tests are specific to the textbook and we have designed tools to make the most of your limited study time.
Posted in Education

Introduction to Genomic Signal Processing with Control

Author: Aniruddha Datta,Edward R. Dougherty

Publisher: CRC Press

ISBN: 9781420006674

Category: Technology & Engineering

Page: 288

View: 6733

Studying large sets of genes and their collective function requires tools that can easily handle huge amounts of information. Recent research indicates that engineering approaches for prediction, signal processing, and control are well suited for studying multivariate interactions. A tutorial guide to the current engineering research in genomics, Introduction to Genomic Signal Processing with Control provides a state-of-the-art account of the use of control theory to obtain intervention strategies for gene regulatory networks. The book builds up the necessary molecular biology background with a basic review of organic chemistry and an introduction of DNA, RNA, and proteins, followed by a description of the processes of transcription and translation and the genetic code that is used to carry out the latter. It discusses control of gene expression, introduces genetic engineering tools such as microarrays and PCR, and covers cell cycle control and tissue renewal in multi-cellular organisms. The authors then delineate how the engineering approaches of classification and clustering are appropriate for carrying out gene-based disease classification. This leads naturally to expression prediction, which in turn leads to genetic regulatory networks. The book concludes with a discussion of control approaches that can be used to alter the behavior of such networks in the hope that this alteration will move the network from a diseased state to a disease-free state. Written by recognized leaders in this emerging field, the book provides the exact amount of molecular biology required to understand the engineering applications. It is a self-contained resource that spans the diverse disciplines of molecular biology and electrical engineering.
Posted in Technology & Engineering

Introduction to Protein Science

Architecture, Function, and Genomics

Author: Arthur Lesk

Publisher: Oxford University Press

ISBN: 0199541302

Category: Education

Page: 455

View: 1537

Introduction to Protein Science provides a broad introduction to the contemporary study of proteins in health and disease, suitable for students on biological, biochemical, and biomedical degrees internationally. The book relates the study of proteins to the context of modern high-throughput data streams of genomics and proteomics.
Posted in Education

An Introduction to Ecological Genomics

Author: Nico M. van Straalen,Dick Roelofs

Publisher: Oxford University Press

ISBN: 0199594686

Category: Science

Page: 363

View: 4821

The genomics revolution has expanded from its origins in molecular biology to impact upon every discipline in the life sciences, including ecology. This new edition incorporates a balance of plant, animal, and microbial examples, and continues to define the new and exciting field of ecological genomics.
Posted in Science

Introduction to Marine Genomics

Author: J. Mark Cock,Kristin Tessmar-Raible,Catherine Boyen,Frédérique Viard

Publisher: Springer Science & Business Media

ISBN: 9789048186396

Category: Science

Page: 399

View: 7119

Marine biology has always played an important role in biological research, being at the origin of many key advances. To a certain extent, the influence of marine biology on the biological sciences was overshadowed over a period of several years by the remarkable advances that were made using powerful model organisms from terrestrial environments. This situation is now changing again, however, due primarily to spectacular developments in genomic methodologies that have significantly accelerated research in a broad spectrum of marine biology disciplines ranging from biodiversity to developmental biology to biotechnology. The data generated by marine genomics projects have had an impact on questions as diverse as understanding planetary geochemical cycles, the impact of climate change on marine fauna and flora, the functioning of marine ecosystems, the discovery of new organisms and novel biomolecules, and investigation of the evolution of animal developmental complexity. This book represents the first attempt to document how genomic technologies are revolutionising these diverse domains of marine biology. Each chapter of this book looks at how these technologies are being employed in a specific domain of marine research and provides a summary of the major results obtained to date. The book as a whole provides an overview of marine genomics as a discipline and represents an ideal starting point for exploring this rapidly developing domain.
Posted in Science

Handbook of Genomics and the Family

Psychosocial Context for Children and Adolescents

Author: Kenneth P. Tercyak

Publisher: Springer Science & Business Media

ISBN: 9781441958006

Category: Medical

Page: 615

View: 2883

This book introduces readers to the study of how genes, singly and in combination with each other and the environment, affect health and behavior. It provides family-focused perspectives relating to genetic counseling and education.
Posted in Medical

Introduction to Biological Networks

Author: Alpan Raval,Animesh Ray

Publisher: CRC Press

ISBN: 1420010360

Category: Mathematics

Page: 335

View: 5078

The new research area of genomics-inspired network biology lacks an introductory book that enables both physical/computational scientists and biologists to obtain a general yet sufficiently rigorous perspective of current thinking. Filling this gap, Introduction to Biological Networks provides a thorough introduction to genomics-inspired network biology for physical scientists and biologists involved in interdisciplinary research. The book focuses on the concept of molecular and genetic interaction networks as a paradigm for interpreting the complexity of molecular biology at a genomic scale. The authors describe the experimental methods used to discover and test networks of interaction among biological molecules. They also present computational methods for predicting the interaction networks, discuss general mechanisms of network formation and evolution, and explore the application of network approaches to important problems in biology and medicine. With many examples throughout and clear explanations of key concepts, this book is the first to offer a broad treatment of genomics-inspired network biology with sufficient mathematical and biological rigor. It gives readers a conceptual understanding of this burgeoning scientific field.
Posted in Mathematics

Introduction to Computational Genomics

A Case Studies Approach

Author: Nello Cristianini,Matthew W. Hahn

Publisher: Cambridge University Press

ISBN: 1139460153

Category: Computers

Page: N.A

View: 590

Where did SARS come from? Have we inherited genes from Neanderthals? How do plants use their internal clock? The genomic revolution in biology enables us to answer such questions. But the revolution would have been impossible without the support of powerful computational and statistical methods that enable us to exploit genomic data. Many universities are introducing courses to train the next generation of bioinformaticians: biologists fluent in mathematics and computer science, and data analysts familiar with biology. This readable and entertaining book, based on successful taught courses, provides a roadmap to navigate entry to this field. It guides the reader through key achievements of bioinformatics, using a hands-on approach. Statistical sequence analysis, sequence alignment, hidden Markov models, gene and motif finding and more, are introduced in a rigorous yet accessible way. A companion website provides the reader with Matlab-related software tools for reproducing the steps demonstrated in the book.
Posted in Computers

Introduction to Plant Biotechnology

Author: H. S. Chawla

Publisher: Science Publishers

ISBN: 9781578082285

Category: Technology & Engineering

Page: 538

View: 1675

Plant biotechnology has created unprecedented opportunities for the manipulation of biological systems of plants. To understand biotechnology, it is essential to know the basic aspects of genes and their organization in the genome of plant cells. This text on the subject is aimed at students.
Posted in Technology & Engineering

Genomics in Drug Discovery and Development

Author: Dimitri Semizarov,Eric Blomme

Publisher: John Wiley & Sons

ISBN: 0470409762

Category: Medical

Page: 448

View: 3663

Early characterization of toxicity and efficacy would significantly impact the overall productivity of pharmaceutical R&D and reduce drug candidate attrition and failure. By describing the available platforms and weighing their relative advantages and disadvantages, including microarray data analysis, Genomics in Drug Discovery and Development introduces readers to the biomarker, pharmacogenomic, and toxicogenomics toolbox. The authors provide a valuable resource for pharmaceutical discovery scientists, preclinical drug safety department personnel, regulatory personnel, discovery toxicologists, and safety scientists, drug development professionals, and pharmaceutical scientists.
Posted in Medical

Statistical Genomics

Linkage, Mapping, and QTL Analysis

Author: Ben Hui Liu

Publisher: CRC Press

ISBN: 9780849331664

Category: Mathematics

Page: 648

View: 5396

Genomics, the mapping of the entire genetic complement of an organism, is the new frontier in biology. This handbook on the statistical issues of genomics covers current methods and the tried-and-true classical approaches.
Posted in Mathematics

Genomics and Bioinformatics

An Introduction to Programming Tools for Life Scientists

Author: Tore Samuelsson

Publisher: Cambridge University Press

ISBN: 1107008565

Category: Computers

Page: 338

View: 9408

A hands-on introduction to Unix, Perl and other bioinformatics tools using relevant and interesting molecular biology problems.
Posted in Computers

Fungal Genomics

Author: N.A

Publisher: Elsevier

ISBN: 9780080527468

Category: Science

Page: 432

View: 9585

Research in the genomics of a handful of fungi has matured at an unprecedented rate allowing comprehensive review. Developments in fungal genomics should be of great significance to new strategies in fields where disciplinary crossovers of fungal genomics, genes and their regulation, expression, and engineering will have a strong impact in dealing with agriculture, foods, natural resources, life sciences, biotechnology, informatics, metabolomics, pharmaceuticals and bioactive compounds. This volume analyzes the commonly used molecular markers systems, and elaborates the development of biochemical genetics, which provides a model system that established the relationship between genes and enzymes. Current knowledge about the genomic and genetic variability of Candida albicans, the polymorphic fungus that is an opportunistic human pathogen of increasing medical importance, has been covered in detail. Current understanding of the genetics and functional genomic analysis of the most important fungal pathogens of staple food crops, rice and wheat among others is covered including chapters dealing with the genomics of economically important fungi such asMagnaporthe grisea, Aspergillus, Fusarium, Penicillium, Trichoderma, Rhizoctonia, Mycosphaerella graminicola, and entomopathogenic fungi. With several thousand recent citations, it is hoped that volume four will serve as a useful reference for knowledgeable veterans and beginners as well as those crossing disciplinary boundaries into the exciting field of biotechnology, genomics and bioinformatics of fungi.
Posted in Science

Omics in Clinical Practice

Genomics, Pharmacogenomics, Proteomics, and Transcriptomics in Clinical Research

Author: Yu Liu

Publisher: CRC Press

ISBN: 1771880600

Category: Science

Page: 464

View: 7802

This book serves as an introduction to genomics, proteomics, and transcriptomics, putting these fields in relation to human disease and ailments. The various chapters consider the role of translation and personalized medicine, as well as pathogen detection, evolution, and infection, in relation to genomics, proteomics, and transcriptomics. The topic of companion diagnostics is also covered. The book is broken into five sections. Part I examines the connection between omics and human disease. Part II looks at the applications for the fields of translational and personalized medicine. Part III focuses on molecular and genetic markers. Part IV describes the use of omics while studying pathogens, and Part V examines the applications for companion diagnostics. The book: • Introduces genomics, proteomics, and transcriptomics in relation to human disease and ailments • Considers the role of translation and personalized medicine in relation to genomics, proteomics, and transcriptomics • Covers molecular and genetic markers • Considers the role of genomics, proteomics, and transcriptomics in relation to pathogen detection, evolution, and infection • Covers companion diagnostics in relation to genomics, proteomics, and transcriptomics clinical applications and research
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Exploring Personal Genomics

Author: Joel T. Dudley,Konrad J. Karczewski

Publisher: OUP Oxford

ISBN: 019166376X

Category: Science

Page: 256

View: 1830

Rapid advances in high-throughput genome sequencing technologies foreshadow a near-future in which millions of individuals will gain affordable access to their complete genome sequence. This promises to offer unprecedented insights into the fundamental biological nature of ourselves and our species: where we came from, how we begin our lives, how we develop and grow, how we interact with our environment, how we get sick, how we get well, and how we age. Personal genomics is an essential component of the inevitable transition towards personalized health and medicine. As the medical establishment begins to explore and evaluate the role of personal genomics in health and medicine, both clinicians and patients alike will gain from becoming well versed in both the power and the pitfalls of personal genomic information. Furthermore, it is likely that all students of the biomedical sciences will soon be required to gain crucial understanding in the emerging field of personal genomics. Exploring Personal Genomics provides a novel, inquiry-based approach to the understanding and interpretation of the practical, medical, physiological, and societal aspects of personal genomic information. The material is presented in two parts: the first provides readers of all backgrounds with a fundamental understanding of the biology of human genomes, information on how to obtain and understand digital representations of personal genomic data, tools and techniques for exploring the personal genomics of ancestry and genealogy, discovery and interpretation of genetic trait associations, and the role of personal genomics in drug response. The second part offers more advanced readers an understanding of the science, tools, and techniques for investigating interactions between a personal genome and the environment, connecting DNA to physiology, and assessing rare variants and structural variation. This book aims to support undergraduate and graduate studies in medicine, genetics, molecular biology, and bioinformatics. Additionally, the design of the content is such that medical practitioners, professionals working in the biomedical sciences or related fields, and motivated lay individuals interested in exploring their personal genetic data should find it relevant and approachable.
Posted in Science

Fundamentals of Data Mining in Genomics and Proteomics

Author: Werner Dubitzky,Martin Granzow,Daniel P. Berrar

Publisher: Springer Science & Business Media

ISBN: 0387475095

Category: Science

Page: 281

View: 9215

This book presents state-of-the-art analytical methods from statistics and data mining for the analysis of high-throughput data from genomics and proteomics. It adopts an approach focusing on concepts and applications and presents key analytical techniques for the analysis of genomics and proteomics data by detailing their underlying principles, merits and limitations.
Posted in Science

Genetics, Genomics and Breeding of Eucalypts

Author: Robert J. Henry

Publisher: CRC Press

ISBN: 1482254131

Category: Science

Page: 206

View: 2843

Eucalypts are used for the production of paper products, firewood, charcoal, potential feedstocks for bioenergy and biomaterials, as ornamentals and landscape trees, and in land rehabilitation. Eucalypt breeding is at an early stage with many plantings being only at the first stages of domestication. The relatively small genomes of these species make the application of molecular genetics approaches attractive. The application of modern genomics will accelerate the development of improved eucalypts for a wide range of uses. This book brings together diverse information on the genetics, genomics, and breeding of these important forest species.
Posted in Science

Mad Cows and Mother's Milk, Second Edition

The Perils of Poor Risk Communication

Author: William Leiss,Douglas Alan Powell

Publisher: McGill-Queen's Press - MQUP

ISBN: 9780773528178

Category: Medical

Page: 452

View: 6042

An evaluation of the crucial role of risk communication in dealing with public controversies.
Posted in Medical