Introduction to Enzyme and Coenzyme Chemistry

Author: T. D. H. Bugg

Publisher: John Wiley & Sons

ISBN: 1118348990

Category: Science

Page: 280

View: 898

Enzymes are giant macromolecules which catalyse biochemical reactions. They are remarkable in many ways. Their three-dimensional structures are highly complex, yet they are formed by spontaneous folding of a linear polypeptide chain. Their catalytic properties are far more impressive than synthetic catalysts which operate under more extreme conditions. Each enzyme catalyses a single chemical reaction on a particular chemical substrate with very high enantioselectivity and enantiospecificity at rates which approach “catalytic perfection”. Living cells are capable of carrying out a huge repertoire of enzyme-catalysed chemical reactions, some of which have little or no precedent in organic chemistry. The popular textbook Introduction to Enzyme and Coenzyme Chemistry has been thoroughly updated to include information on the most recent advances in our understanding of enzyme action, with additional recent examples from the literature used to illustrate key points. A major new feature is the inclusion of two-colour figures, and the addition of over 40 new figures of the active sites of enzymes discussed in the text, in order to illustrate the interplay between enzyme structure and function. This new edition provides a concise but comprehensive account from the perspective of organic chemistry, what enzymes are, how they work, and how they catalyse many of the major classes of enzymatic reactions, and will continue to prove invaluable to both undergraduate and postgraduate students of organic, bio-organic and medicinal chemistry, chemical biology, biochemistry and biotechnology.
Posted in Science

Fundamentals of Enzyme Kinetics

Author: Athel Cornish-Bowden

Publisher: Elsevier

ISBN: 1483161196

Category: Science

Page: 244

View: 3482

Fundamentals of Enzyme Kinetics details the rate of reactions catalyzed by different enzymes and the effects of varying the conditions on them. The book includes the basic principles of chemical kinetics, especially the order of a reaction and its rate constraints. The text also gives an introduction to enzyme kinetics - the idea of an enzyme-substrate complex; the Michaelis-Menten equation; the steady state treatment; and the validity of its assumption. Practical considerations, the derivation of steady-state rate equations, inhibitors and activators, and two-substrate reactions are also explained. Problems after the end of each chapter have also been added, as well as their solutions at the end of the book, to test the readers' learning. The text is highly recommended for undergraduate students in biochemistry who wish to study about enzymes or focus completely on enzymology, as most of the mathematics used in this book, which have been explained in detail to remove most barriers of understanding, is elementary.
Posted in Science

Allosteric Regulatory Enzymes

Author: Thomas W. Traut

Publisher: Springer Science & Business Media

ISBN: 0387728910

Category: Science

Page: 250

View: 3412

This book covers the most recent developments in the analysis of allosteric enzymes and provides a logical introduction to the limits for enzyme function as dictated by the factors that are limits for life. The book presents a complete description of all the mechanisms used for changing enzyme activity. It is extensively illustrated to clarify kinetic and regulatory properties. Eight enzymes are used as model systems after extensive study of their mechanisms. Wherever possible, the human form of the enzyme is used to illustrate the regulatory features.
Posted in Science

Introduction to Enzymology

Author: Alan H. Mehler

Publisher: Elsevier

ISBN: 1483258475

Category: Science

Page: 439

View: 6253

Introduction to Enzymology focuses on the processes, methodologies, reactions, and approaches involved in enzyme chemistry. The book first offers information on the hydrolysis of peptides and proteins and fermentation and oxidation of major metabolic fuels. Discussions focus on oxidation of fatty acids, alternative pathways of carbohydrate metabolism, Krebs citric acid cycle, free energy and the concept of bond energy, pyruvate oxidation and acetyl coenzyme A formation, and glycolysis. The text then elaborates on the transfer of oxygen, hydrogen, and electrons and sugars and sugar derivatives. The publication takes a look at polynucleotides and their components, amino acids, and acids and acid derivatives. Topics include carbonic anhydrase, mechanism of action of pyridoxal phosphate enzymes, aromatic ring biosynthesis and metabolism of phenylalanine and tyrosine, metabolism of sulfur-containing amino acids, and oxidation of amino acids. The book is a valuable reference for chemists and researchers interested in enzymology.
Posted in Science

Introduction to Bioengineering

Author: Y C Fung

Publisher: World Scientific Publishing Company

ISBN: 9813102799

Category: Science

Page: 312

View: 2544

Bioengineering is attracting many high quality students. This invaluable book has been written for beginning students of bioengineering, and is aimed at instilling a sense of engineering in them. Engineering is invention and designing things that do not exist in nature for the benefit of humanity. Invention can be taught by making inventive thinking a conscious part of our daily life. This is the approach taken by the authors of this book. Each author discusses an ongoing project, and gives a sample of a professional publication. Students are asked to work through a sequence of assignments and write a report. Almost everybody soon realizes that more scientific knowledge is needed, and a strong motivation for the study of science is generated. The teaching of inventive thinking is a new trend in engineering education. Bioengineering is a good field with which to begin this revolution in engineering education, because it is a youthful, developing interdisciplinary field.
Posted in Science

Enzyme Biocatalysis

Principles and Applications

Author: Andrés Illanes

Publisher: Springer Science & Business Media

ISBN: 1402083610

Category: Technology & Engineering

Page: 392

View: 9054

This book was written with the purpose of providing a sound basis for the design of enzymatic reactions based on kinetic principles, but also to give an updated vision of the potentials and limitations of biocatalysis, especially with respect to recent app- cations in processes of organic synthesis. The ?rst ?ve chapters are structured in the form of a textbook, going from the basic principles of enzyme structure and fu- tion to reactor design for homogeneous systems with soluble enzymes and hete- geneous systems with immobilized enzymes. The last chapter of the book is divided into six sections that represent illustrative case studies of biocatalytic processes of industrial relevance or potential, written by experts in the respective ?elds. We sincerely hope that this book will represent an element in the toolbox of gr- uate students in applied biology and chemical and biochemical engineering and also of undergraduate students with formal training in organic chemistry, biochemistry, thermodynamics and chemical reaction kinetics. Beyond that, the book pretends also to illustrate the potential of biocatalytic processes with case studies in the ?eld of organic synthesis, which we hope will be of interest for the academia and prof- sionals involved in R&D&I. If some of our young readers are encouraged to engage or persevere in their work in biocatalysis this will certainly be our more precious reward.
Posted in Technology & Engineering

Enzyme Biocatalysis

Principles and Applications

Author: Andrés Illanes

Publisher: Springer Science & Business Media

ISBN: 1402083610

Category: Technology & Engineering

Page: 392

View: 1796

This book was written with the purpose of providing a sound basis for the design of enzymatic reactions based on kinetic principles, but also to give an updated vision of the potentials and limitations of biocatalysis, especially with respect to recent app- cations in processes of organic synthesis. The ?rst ?ve chapters are structured in the form of a textbook, going from the basic principles of enzyme structure and fu- tion to reactor design for homogeneous systems with soluble enzymes and hete- geneous systems with immobilized enzymes. The last chapter of the book is divided into six sections that represent illustrative case studies of biocatalytic processes of industrial relevance or potential, written by experts in the respective ?elds. We sincerely hope that this book will represent an element in the toolbox of gr- uate students in applied biology and chemical and biochemical engineering and also of undergraduate students with formal training in organic chemistry, biochemistry, thermodynamics and chemical reaction kinetics. Beyond that, the book pretends also to illustrate the potential of biocatalytic processes with case studies in the ?eld of organic synthesis, which we hope will be of interest for the academia and prof- sionals involved in R&D&I. If some of our young readers are encouraged to engage or persevere in their work in biocatalysis this will certainly be our more precious reward.
Posted in Technology & Engineering

Biology

An Introduction to Medical and Other Studies

Author: Patrick Desmond Fitzgerald Murray

Publisher: N.A

ISBN: N.A

Category: Biology

Page: 601

View: 5245

Posted in Biology

Polar Microbiology

Life in a Deep Freeze

Author: Robert V. Miller,Lyle Whyte

Publisher: American Society for Microbiology Press

ISBN: 1555816045

Category: Science

Page: 334

View: 1401

Sheds new light on the microbial ecology and physiology of the Earth’s polar regions. • Examines the microbial investigations during the International Polar Year of 2008 focusing on the Arctic and Antarctic, along with earlier investigations on critical environmental issues such as climate change, ozone depletion, and elemental cycling. • Offers a survey of what is known and unknown about the microbial inhabitants of polar environments, addresses the adaptations and physiology of cold-adapted microorganisms, and explores the ecological role that polar microbial communities play in biogeochemical cycling. • Presents the challenges that polar and subpolar microorganisms face and describes the lowest temperatures in which microbial life can exist—and the prospects for life on other planets. Recommended for a general microbiology audience as well as for scientists and students in all areas of biology and geomicrobiology.
Posted in Science

An Introduction to Zoo Biology and Management

Author: Paul A. Rees

Publisher: John Wiley & Sons

ISBN: 9781444397833

Category: Science

Page: 432

View: 4307

This book is intended as an introductory text for students studying a wide range of courses concerned with animal management, zoo biology and wildlife conservation, and should also be useful to zookeepers and other zoo professionals. It is divided into three parts. Part 1 considers the function of zoos, their history, how zoos are managed, ethics, zoo legislation and wildlife conservation law. Part 2 discusses the design of zoos and zoo exhibits, animal nutrition, reproduction, animal behaviour (including enrichment and training), animal welfare, veterinary care, animal handling and transportation. Finally, Part 3 discusses captive breeding programmes, genetics, population biology, record keeping, and the educational role of zoos, including a consideration of visitor behaviour. It concludes with a discussion of the role of zoos in the conservation of species in the wild and in species reintroductions. This book takes an international perspective and includes a wide range of examples of the operation of zoos and breeding programmes particularly in the UK, Europe, North America and Australasia. Visit www.wiley.com/go/rees/zoo to access the artwork from the book.
Posted in Science

Genetics and the Origin of Species

Author: Theodosius Dobzhansky,Theodosius Grigorievich Dobzhansky

Publisher: Columbia University Press

ISBN: 9780231054751

Category: Science

Page: 364

View: 1722

Featuring an introduction by Stephen Jay Gould, "Genetics and the Origin of Species" presents the first edition of Dobzhansky's groundbreaking and now classic inquiry into what has emerged as the most important single area of scientific inquiry in the twentieth century: biological theory of evolution. Genetics and the Origin of Species went through three editions (1937, 1941, and 1951) in which the importance accorded natural selection changed radically.
Posted in Science

The Oxford Companion to Food

Author: Alan Davidson

Publisher: Oxford University Press, USA

ISBN: 0199677336

Category: Cooking

Page: 921

View: 8672

Covers such topics as plant products, cooking terms, national and regional cuisines, food preservation, food science, diet, and cookbooks and their authors.
Posted in Cooking

A Textbook Of Medicinal Biochemistry

Author: N.A

Publisher: New Age International

ISBN: 9788122409246

Category:

Page: 632

View: 9505

This Book Covers The Syllabus Of Biochemistry Prescribed By Different Indian Universities For The Preclinical Students Of Medical Colleges. It Is Intended To Provide A Broad Knowledge Of General Biochemistry With Essentials Of Some Rapidly Advancing Fields Like Immunochemistry, Nucleic Acids, Protein Synthesis And Gene Expression.The Book Includes Relevant Basic Physical Chemistry And Organic Chemistry With Detailed Presentation Of The Biomolecules Together With Structure And Function Of The Living Cell. The Special Factors Involved In Biochemical Reactions Are Dealt With For Their Chemical Nature And Mechanism Of Action Based On Current Advances Of Molecular Basis.General Metabolic Reactions Are Explained Diagrammatically With Up-To-Date Information In Terms Of Structure Of Molecules. Metabolic Changes Under Special Conditions Like Starvation, High Altitude, Deep Sea Diving, Astronautical Flights, Sports And Disease Conditions Are Included.A Correlating Link Has Been Maintained Throughout With Clinical Medicine Wherever Applicable. Digestion, Absorption, Organ Functions And Changes Of Blood Constitutions In Diseases Are Given With Sufficient Details For An Easy Follow-Up In Contemporary And Future Subjects Of Study By The Students In The Medical Course.Medicinal Subjects, Not Usually Included In General Biochemistry Such As Contraception, Toxicology. Nutrition Radioisotopes And Antimetabolites Are Also Described With Enough Fundamentals For A Thorough Understanding.
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The Code Red Revolution

How Thousands of People Are Losing Weight and Keeping It Off Without Pills, Shakes, Diet Foods, Or Exercise

Author: Cristy Nickel

Publisher: N.A

ISBN: 9781944602093

Category: Health & Fitness

Page: 310

View: 2742

What if you could lose as much weight as you wanted Without spending money on pills, powders, weird diet food, or even exercise? The Code Red Revolution is all about taking your life back by eating real food and giving your body what it needs-water, Real Food, and plenty of sleep. Maintaining a healthy weight doesn't have to be complicated. In fact, when you keep it simple and just follow a few basic rules, the weight comes off naturally (even if you have health challenges). Most weight-loss books and plans teach you one magical way to lose weight, but they don't take into account just how wonderfully individual we all are. This book shows you how to integrate the simple-but-effective program recommendations into your daily life. Stay-at-home parent cooking for fussy eaters? We gotcha covered. Travel for work and are rarely home to cook? You can absolutely learn how to eat in restaurants and still lose weight. Allergic to certain types of foods? We can work with that. Couch potato? No problem! Vegetarian (or a really-hate-vegetables-tarian)? You can do this. Thousands of people around the world have already lost 10, 50, even 100 pounds with the Code Red Lifestyle. And they've kept the weight off for Years. Isn't it time you learned the secret to lasting weight loss? Make this time the last time you have to lose weight. Book jacket.
Posted in Health & Fitness

Enzyme mechanisms

Author: Michael I. Page,Royal Society of Chemistry (Great Britain)

Publisher: Scholium International

ISBN: N.A

Category: Science

Page: 550

View: 6521

Theories of enzyme catalysis. Enzyme models - synthetic polymers. Enzyme models - crown ethers. Enzyme models - cyclodextrins (cycloamyloses). Enzyme models - small molecule and intramolecular catalysis. Use of protein engineering to study enzyme mechanisms. Transition state affinity and the design of enzyme inhibitors. Acyl group transfer -fundamental mechanisms, cysteine proteinases, the serine proteinases, phosphoryl transfer, sulphotransferases and sulphatases, aspartic proteinases, metalloproteinases. Glycosil group transfer. Isomerization mechanisms through hydrogem and carbon transfer. Imine formation in enzimatic reactions. Pyridoxal phosphate dependent enzymes. Thiamine-depedent enzymes. Adenosylcobalamin-dependent enzymic reactions. Folate-dependent enzymes. Glutathione-dependent enzymes-chemistry. Glutathione-dependent enzymes - glutathione-S-transferases. Oxido-reductases - pyridine nucleotide-dependent enzymes. Oxido-reductases - flavoenzymes. Multi-enzyme complexes - Eukaryotic fatty acid synthases.
Posted in Science

Computational Intelligence

An Introduction

Author: Andries P. Engelbrecht

Publisher: John Wiley & Sons

ISBN: 9780470512500

Category: Technology & Engineering

Page: 628

View: 3321

Computational Intelligence: An Introduction, Second Edition offers an in-depth exploration into the adaptive mechanisms that enable intelligent behaviour in complex and changing environments. The main focus of this text is centred on the computational modelling of biological and natural intelligent systems, encompassing swarm intelligence, fuzzy systems, artificial neutral networks, artificial immune systems and evolutionary computation. Engelbrecht provides readers with a wide knowledge of Computational Intelligence (CI) paradigms and algorithms; inviting readers to implement and problem solve real-world, complex problems within the CI development framework. This implementation framework will enable readers to tackle new problems without any difficulty through a single Java class as part of the CI library. Key features of this second edition include: A tutorial, hands-on based presentation of the material. State-of-the-art coverage of the most recent developments in computational intelligence with more elaborate discussions on intelligence and artificial intelligence (AI). New discussion of Darwinian evolution versus Lamarckian evolution, also including swarm robotics, hybrid systems and artificial immune systems. A section on how to perform empirical studies; topics including statistical analysis of stochastic algorithms, and an open source library of CI algorithms. Tables, illustrations, graphs, examples, assignments, Java code implementing the algorithms, and a complete CI implementation and experimental framework. Computational Intelligence: An Introduction, Second Edition is essential reading for third and fourth year undergraduate and postgraduate students studying CI. The first edition has been prescribed by a number of overseas universities and is thus a valuable teaching tool. In addition, it will also be a useful resource for researchers in Computational Intelligence and Artificial Intelligence, as well as engineers, statisticians, operational researchers, and bioinformaticians with an interest in applying AI or CI to solve problems in their domains. Check out http://www.ci.cs.up.ac.za for examples, assignments and Java code implementing the algorithms.
Posted in Technology & Engineering

Biochemistry and Oral Biology

Author: A. S. Cole,J. E. Eastoe

Publisher: Butterworth-Heinemann

ISBN: 1483183718

Category: Science

Page: 570

View: 2370

Biochemistry and Oral Biology presents a unique exposition of biochemistry suitable for dental students. It discusses the structural basis of metabolism and the general principles of nutrition. It addresses the soft tissues, hard tissues, and the biology of the mouth. Some of the topics covered in the book are the free radical production; scope of biochemistry; characteristics of atoms; structure and properties of water; molecular building materials; ionization of proteins; affinity chromatography of proteins; structural organization of globular proteins; classification of enzymes; and biochemically important sugar derivatives. The naturally occurring fatty acids are fully covered. The nucleic acid components are discussed in detail. The text describes in depth the energy equivalents of different nutrients. The physiological effects of dietary fiber vitamin D deficiency are completely presented. A chapter is devoted to the alternative methods of fluoride administration and description of vitamins. The book can provide useful information to dental students, and researchers.
Posted in Science

Fermentation Microbiology and Biotechnology, Third Edition

Author: E. M. T. El-Mansi,C. F. A. Bryce,Arnold L. Demain,A.R. Allman

Publisher: CRC Press

ISBN: 1439855811

Category: Medical

Page: 555

View: 7013

Fermentation Microbiology and Biotechnology, Third Edition explores and illustrates the diverse array of metabolic pathways employed for the production of primary and secondary metabolites as well as biopharmaceuticals. This updated and expanded edition addresses the whole spectrum of fermentation biotechnology, from fermentation kinetics and dynamics to protein and co-factor engineering. The third edition builds upon the fine pedigree of its earlier predecessors and extends the spectrum of the book to reflect the multidisciplinary and buoyant nature of this subject area. To that end, the book contains four new chapters: Functional Genomics Solid-State Fermentations Applications of Metabolomics to Microbial Cell Factories Current Trends in Culturing Complex Plant Tissues for the Production of Metabolites and Elite Genotypes Organized and written in a concise manner, the book’s accessibility is enhanced by the inclusion of definition boxes in the margins explaining any new concept or specific term. The text also contains a significant number of case studies that illustrate current trends and their applications in the field. With contributions from a global group of eminent academics and industry experts, this book is certain to pave the way for new innovations in the exploitation of microorganisms for the benefit of mankind.
Posted in Medical