Handbook of Pharmaceutical Excipients

Author: Raymond C. Rowe,Paul J. Sheskey,Marian E. Quinn

Publisher: N.A

ISBN: 9780853697947

Category: Medical

Page: 888

View: 3431

An internationally acclaimed reference work recognized as one of the most authoritative and comprehensive sources of information on excipients used in pharmaceutical formulation with this new edition providing 340 excipient monographs. Incorporates information on the uses, and chemical and physical properties of excipients systematically collated from a variety of international sources including: pharmacopeias, patents, primary and secondary literature, websites, and manufacturers' data; extensive data provided on the applications, licensing, and safety of excipients; comprehensively cross-referenced and indexed, with many additional excipients described as related substances and an international supplier's directory and detailed information on trade names and specific grades or types of excipients commercially available.
Posted in Medical

Handbook of pharmaceutical excipients

Author: Ainley Wade,Pharmaceutical Society of Great Britain

Publisher: Pharmaceutical Press

ISBN: N.A

Category: Medical

Page: 651

View: 8175

Provides data on the additives used to convert pharmacologically active compounds into dosage forms suitable for administration to patients. Data includes: nonproprietary names, functional category, synonyms, chemical names and CAS Registry number, empirical formula, molecular weight, structural formula, commercial availability, method of manufacture,description, pharmacopeial specifications, typical properties, stability and storage conditions, incompatibilities, safety, handling precautions, regulatory acceptance, applications in pharmaceutical formulation or technology, use, related substances, comments, and specific references.
Posted in Medical

Handbook of Pharmaceutical Excipients

Author: Arthur H. Kibbe

Publisher: Amer Pharmacists Assn

ISBN: 9780917330964

Category: Medical

Page: 665

View: 3194

Describes the chemical and physical properties of pharmaceutical excipients. Each monograph contains nonproprietary names, synonyms, chemical name and CAS registry number, empirical formula and molecular weight, structural formula, functional category, applications in pharmaceutical formulation or technology, description, pharmacopeial specifications, typical propertics, stability and storage conditions, incompatibilities, method of manufacture, safety, handling precautions, regulatory status, pharmacopeias, related substances, comments, specific references, general references, and authors.
Posted in Medical

Handbook of Pharmaceutical Excipients

Author: Raymond C. Rowe,Paul J. Sheskey,Walter G. Cook,Marian E. Fenton

Publisher: N.A

ISBN: 9780857110275

Category: Medical

Page: 1033

View: 8857

An internationally acclaimed reference work recognized as one of the most authoritative and comprehensive sources of information on excipients used in pharmaceutical formulation with this new edition providing 340 excipient monographs. Incorporates information on the uses, and chemical and physical properties of excipients systematically collated from a variety of international sources including: pharmacopeias, patents, primary and secondary literature, websites, and manufacturers' data; extensive data provided on the applications, licensing, and safety of excipients; comprehensively cross-referenced and indexed, with many additional excipients described as related substances and an international supplier's directory and detailed information on trade names and specific grades or types of excipients commercially available
Posted in Medical

Pharmaceutical Excipients 2001

Handbook of Pharmaceutical Excipients

Author: Pharmaceutical Press,Raymond C. Rowe,Paul J Sheskey,Paul J Weller

Publisher: N.A

ISBN: 9780853694977

Category: Medical

Page: N.A

View: 9775

Posted in Medical

Handbook of Pharmaceutical Excipients

Author: Paul J. Sheskey,Walter G. Cook,Colin G. Cable

Publisher: N.A

ISBN: 9780857112712

Category: Excipients

Page: 1216

View: 2224

The Handbook of Pharmaceutical Excipients contains essential data on the physical properties of excipients, their safe use and potential toxicity.
Posted in Excipients

Arzneimitteltherapie in der Palliativmedizin

Author: Claudia Bausewein,Constanze Rémi,Robert Twycross,Andrew Wilcock,Paul Howard

Publisher: Elsevier Health Sciences

ISBN: 3437183958

Category: Medical

Page: 1048

View: 9182

Dieses Werk bietet praxisorientierte, konkrete Handlungsanweisungen mit exakten Dosierungsangaben und zahlreichen Tipps für die tägliche Praxis. Es liefert präzise Informationen zu Sonderfällen wie z.B. Anwendungen außerhalb der Zulassung (''off-label use''), alternative Applikationsformen sowie Dosierungsanpassung bei Organinsuffizienz. Das ideale Buch zur kompetenten und sicheren Behandlung von Patienten in der Palliativmedizin. Die deutsche Fassung basiert auf dem renommierten englischen Werk ''Palliative Care Formulary'', wurde aber auf die Erfordernisse im deutschen Sprachraum angepasst. Neu in der 3. Auflage: Aktualisiert und auf Stand des englischen PCF6 gebracht Die S3-Leitlinie Palliativmedizin für Patienten mit einer nicht heilbaren Krebserkrankung wurde ergänzt Weitere relevante deutsche Leitlinien berücksichtigt
Posted in Medical

Die Regeln der Arbeit

Author: Richard Templar

Publisher: books4success

ISBN: 3941493132

Category: Self-Help

Page: 250

View: 6195

Für manche Menschen ist der Arbeitsalltag das schiere Vergnügen. Scheinbar ohne sich anzustrengen meistern Sie die Fallstricke der Büropolitik. Sie sagen und tun das Richtige, sie bekommen die Gehaltserhöhung, sie werden befördert. Was wissen diese Glücklichen, was alle anderen scheinbar nicht wissen? Sie kennen die Regeln. Die Regeln der Arbeit. Diese Regeln sind überraschend einfach zu lernen - und wenn man sie einmal kennt, dann kann man sie ebenso einfach im täglichen Leben beibehalten. Richard Templar hat sie in einem Buch zusammengefasst: den "Regeln der Arbeit". Erfahren Sie, wie Sie vorankommen, ohne Ihre Prinzipien aufgeben zu müssen; wie Sie das Selbstvertrauen und die Energie ausstrahlen, die Vertrauen und Respekt erzeugen; wie Sie die perfekte Nische für sich schaffen; wie Sie Konflikte lösen ohne die anderen vor den Kopf zu stoßen; und last but not least: wie Sie in den Schlüsselmomenten, die Ihre Karriere beflügeln können, aktiv, präsent und erfolgreich sind.
Posted in Self-Help

CRC Handbook of Food, Drug, and Cosmetic Excipients

Author: Susan C. Smolinske

Publisher: Routledge

ISBN: 1351457373

Category: Technology & Engineering

Page: 448

View: 1270

CRC Handbook of Food, Drug, and Cosmetic Excipients provides a comprehensive summary of toxicological issues regarding inactive ingredients in pharmaceutical products, cosmetic products, and food additives. Background information on regulations and labeling requirements for each type of product is provided, and 77 articles critically review human and animal data pertinent to a variety of agents and makes judgments regarding the clinical relevance. The book also identifies at-risk populations, such as neonates, patients with renal failure, and atopic patients. Inactive common pharmaceutical agents and/or foods containing certain ingredients are listed to help physicians counsel hypersensitive patients who must avoid products containing these excipients.
Posted in Technology & Engineering

Medizinische Mikrobiologie

Author: Ernest Jawetz,Joseph L. Melnick,Edward A. Adelberg

Publisher: Springer-Verlag

ISBN: 3662001551

Category: Science

Page: N.A

View: 7896

Die Autoren haben beabsichtigt, diejenigen Gebiete der medizinischen Mikrobiologie kurz, exakt und in ihrem gegenwärtigen Stand darzustellen, die für die Infektionskrankheiten und ihre Chemotherapie von besonderer Bedeutung sind. Das Buch wendet sich in erster Linie an Medizinstudenten, außerdem an alle Ärzte in Krankenhaus und Praxis. Die Notwendigkeit für ein klares Verständnis der mlkrobiologischen Grundtatsachen ist in den letzten Jahren stärker geworden, da in Biochemie, Virologie und Chemotherapie so wie auf weiteren, die Medizin beeinflussenden Gebieten bedeutende Entwicklungen statt gefunden haben. Ein wesendicher Teil dieses Lehrbuches ist deswegen der Darstellung der Grundlagen gewidmet, wodurch sich das Buch auch für die Einführung des Studenten in den mikrobiologischen Kurs als brauchbar erweisen wird. Für die neue Auflage wurde ein Kapitel über Virus und Krebs neu geschrieben, und das Kapitel über antimikrobielle Chemotherapie wurde von Grund auf neu bearbeitet. Die Autoren freuen sich, bei dem Erscheinen der 7. amerikanischen Ausgabe von einer spanischen, deutschen, italienischen und griechischen Ausgabe, sowie von der Vorbereitung für eine serbokroatische Übersetzung berichten zu können. Die Autoren möchten nochmals allen danken, die ihnen bei der Bearbeitung dieser Auf lage behilflich waren, und die es ihnen durch ihre Kommentare und ihre Kritik ermöglicht haben, die in 2jährigen Abständen erscheinenden Revisionen dieses Buches auf dem neu esten Stand zu halten. ERNEsr JAWETZ JOSEPH L MELNICK San Frandsco, August 1966 EnWARD A AnELBERG III Inhaltsverzeichnis 1 Kapitell Die ~lt der Mikroben 8 Kapitel 2 Cytologie der Bakterien Optische Methoden 8 9 Eukaryote Zellstrukturen Prokaryote Zellstrukturen . 12 14 Cytoplasmatische Strukturen. 27 Färbeverfahren .
Posted in Science

Handbook of Isolation and Characterization of Impurities in Pharmaceuticals

Author: Satinder Ahuja,Karen Mills Alsante

Publisher: Academic Press

ISBN: 9780120449828

Category: Medical

Page: 414

View: 5895

The United States Food and Drug Administration (FDA) and other regulatory bodies around the world require that impurities in drug substance and drug product levels recommended by the International Conference on Harmonisation (ICH) be isolated and characterized. Identifying process-related impurities and degradation products also helps us to understand the production of impurities and assists in defining degradation mechanisms. When this process is performed at an early stage, there is ample time to address various aspects of drug development to prevent or control the production of impurities and degradation products well before the regulatory filing and thus assure production of a high-quality drug product. This book, therefore, has been designed to meet the need for a reference text on the complex process of isolation and characterization of process-related (synthesis and formulation) impurities and degradation products to meet critical requlatory requirements. It's objective is to provide guidance on isolating and characterizing impurities of pharmaceuticals such as drug candidates, drug substances, and drug products. The book outlines impurity identification processes and will be a key resource document for impurity analysis, isolation/synthesis, and characterization. - Provides valuable information on isolation and characterization of impurities. - Gives a regulatory perspective on the subject. - Describes various considerations involved in meeting regulatory requirements. - Discusses various sources of impurities and degredation products.
Posted in Medical

Pharmaceutical Powder Compaction Technology, Second Edition

Author: Metin Çelik

Publisher: CRC Press

ISBN: 1420089188

Category: Medical

Page: 344

View: 1878

Compaction of powder constituents—both active ingredient and excipients—is examined to ensure consistent and reproducible disintegration and dispersion profiles. Revised to reflect modern pharmaceutical compacting techniques, this second edition of Pharmaceutical Powder Compaction Technology guides pharmaceutical engineers, formulation scientists, and product development and quality assurance personnel through the compaction formulation process and application. This unique reference covers: The physical structure of pharmaceutical compacts Bonding phenomena that occur during powder compaction Compression mechanisms of pharmaceutical particles Theories and basic principles of powder compaction New topics include: Compaction data analysis techniques The migration of powder constituents into commercial manufacture Instrumentation for compaction Compaction functionality testing, which is likely to become a USP requirement Design space for compaction Metrics required for scalability in tablet compression Interactive compaction and preformulation database for commonly used excipients
Posted in Medical

Handbook of Pharmaceutical Controlled Release Technology

Author: Donald L. Wise

Publisher: CRC Press

ISBN: 9780824703691

Category: Medical

Page: 902

View: 1800

The Handbook of Pharmaceutical Controlled Release Technology reviews the design, fabrication, methodology, administration, and classifications of various drug delivery systems, including matrices, and membrane controlled reservoir, bioerodible, and pendant chain systems. Contains cutting-edge research on the controlled delivery of biomolecules! Discussing the advantages and limitations of controlled release systems, the Handbook of Pharmaceutical Controlled Release Technology covers oral, transdermal, parenteral, and implantable delivery of drugs discusses modification methods to achieve desired release kinetics highlights constraints of system design for practical clinical application analyzes diffusion equations and mathematical modeling considers environmental acceptance and tissue compatibility of biopolymeric systems for biologically active agents evaluates polymers as drug delivery carriers describes peptide, protein, micro-, and nanoparticulate release systems examines the cost, comfort, disease control, side effects, and patient compliance of numerous delivery systems and devices and more!
Posted in Medical

Handbook of Pharmaceutical Manufacturing Formulations

Sterile Products

Author: Safaraz K. Niazi

Publisher: CRC Press

ISBN: 1420081314

Category: Medical

Page: 464

View: 4247

No other area of regulatory compliance receives more attention and scrutiny by regulatory authorities than the regulation of sterile products, for obvious reasons. With the increasing number of potent products, particularly the new line of small protein products, joining the long list of proven sterile products, the technology of manufacturing sterile products has evolved into a very sophisticated industry. Highlights from Sterile Products, Volume Six include: formulations of sterile dosage forms, regulatory filing requirements of sterile preparations, and cGMP compliance, all of which are tied together in the final preparation of the CMC sections of regulatory applications specifications of a manufacturing facility to manufacture compliant sterile products NDA or aNDA filing requirements of sterile products an alphabetical presentation of formulations of pharmaceutical products based on their generic names
Posted in Medical

The Challenge of CMC Regulatory Compliance for Biopharmaceuticals

Author: John Geigert

Publisher: Springer Science & Business Media

ISBN: 1461469163

Category: Medical

Page: 338

View: 4453

This book highlights the challenges facing quality assurance/quality control (QA/QC) in today's biopharmaceutical environment and presents the strategic importance and value generated by QA/QC for their involvement in control of manufacturing. It will put into perspective the need for a graded approach to QA/QC from early clinical trials through market approval. Since the first edition published in 2004, there have been more than 50 new regulatory guidances released by the Food and Drug Administration (FDA), European Medicines Agency (EMA) and ICH that affect the CMC regulatory compliance of biopharmaceuticals; also the application of biosimilars has been developed in Europe and is under development in the USA. The revised update will be broadened to include not only biopharmaceuticals (biotech drugs) but also other biologics (vaccines, cell therapy, plasma-derived proteins, etc.)
Posted in Medical

Handbook of Pharmaceutical Manufacturing Formulations

Semisolid Products

Author: Sarfaraz K. Niazi

Publisher: CRC Press

ISBN: 1420081276

Category: Medical

Page: 376

View: 3131

The fourth volume in the series covers the techniques and technologies involved in the preparation of semisolid products such as ointments, creams, gels, suppositories, and special topical dosage forms. Drug manufacturers need a thorough understanding of the specific requirements that regulatory agencies impose on the formulation and efficacy determination of drugs contained in these formulations. Highlights from Semisolid Products, Volume Four include: coverage of over 350 formulations valuable information on the difficult area of compliance changes to approved new drug applications and abbreviated new drug applications the evolving guidelines of ICH and when to conduct a regulatory review
Posted in Medical

Preclinical Development Handbook

ADME and Biopharmaceutical Properties

Author: Shayne Cox Gad

Publisher: John Wiley & Sons

ISBN: 0470249021

Category: Medical

Page: 1352

View: 5948

A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques. Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor has carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: * Modeling and informatics in drug design * Bioanalytical chemistry * Absorption of drugs after oral administration * Transporter interactions in the ADME pathway of drugs * Metabolism kinetics * Mechanisms and consequences of drug-drug interactions Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This publication should be readily accessible to all pharmaceutical scientists involved in preclinical testing, enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.
Posted in Medical

Handbook of Pharmaceutical Granulation Technology

Author: Dilip M. Parikh

Publisher: CRC Press

ISBN: 9780824798826

Category: Medical

Page: 528

View: 9636

Integrating the basic principles and industrial practices of pharmaceutical granulation production, this book discusses technologies and demonstrates cost-effective approaches to manufacturing solid-dosage forms with content uniformity and consistent physical properties while complying with regulatory requirements. Specialists from pharmaceutical companies, academia, and the U.S. Drug Regulatory Affairs agency address current and changing practices in industrial drug granulation production. Text, charts, figures, and photographs illustrate the pros and cons of diverse methods and technologies for accurately achieving strong bonding of particles in tablets and capsules.
Posted in Medical