Functional magnetic resonance imaging (fMRI) has become the most popular method for imaging brain function. Handbook of Functional MRI Data Analysis provides a comprehensive and practical introduction to the methods used for fMRI data analysis. Using minimal jargon, this book explains the concepts behind processing fMRI data, focusing on the techniques that are most commonly used in the field. This book provides background about the methods employed by common data analysis packages including FSL, SPM and AFNI. Some of the newest cutting-edge techniques, including pattern classification analysis, connectivity modeling and resting state network analysis, are also discussed. Readers of this book, whether newcomers to the field or experienced researchers, will obtain a deep and effective knowledge of how to employ fMRI analysis to ask scientific questions and become more sophisticated users of fMRI analysis software.
Author: Russell A. Poldrack,Jeanette A. Mumford,Thomas E. Nichols
Publisher: Cambridge University Press
This book explores various state-of-the-art aspects behind the statistical analysis of neuroimaging data. It examines the development of novel statistical approaches to model brain data. Designed for researchers in statistics, biostatistics, computer science, cognitive science, computer engineering, biomedical engineering, applied mathematics, physics, and radiology, the book can also be used as a textbook for graduate-level courses in statistics and biostatistics or as a self-study reference for Ph.D. students in statistics, biostatistics, psychology, neuroscience, and computer science.
Author: Hernando Ombao,Martin Lindquist,Wesley Thompson,John Aston
Publisher: CRC Press
This is the second edition of a useful introductory book on a technique that has revolutionized neuroscience, specifically cognitive neuroscience. Functional magnetic resonance imaging (fMRI) has now become the standard tool for studying the brain systems involved in cognitive and emotional processing. It has also been a major factor in the consilience of the fields of neurobiology, cognitive psychology, social psychology, radiology, physics, mathematics, engineering, and even philosophy. Written and edited by a clinician-scientist in the field, this book remains an excellent user's guide to t
Principles and Techniques
Author: Richard B. Buxton
Publisher: Cambridge University Press
The study of brain function is one of the most fascinating pursuits of m- ern science. Functional neuroimaging is an important component of much of the current research in cognitive, clinical, and social psychology. The exci- ment of studying the brain is recognized in both the popular press and the scienti?c community. In the pages of mainstream publications, including The New York Times and Wired, readers can learn about cutting-edge research into topics such as understanding how customers react to products and - vertisements (“If your brain has a ‘buy button,’ what pushes it?”, The New York Times,October19,2004),howviewersrespondtocampaignads(“Using M. R. I. ’s to see politics on the brain,” The New York Times, April 20, 2004; “This is your brain on Hillary: Political neuroscience hits new low,” Wired, November 12,2007),howmen and womenreactto sexualstimulation (“Brain scans arouse researchers,”Wired, April 19, 2004), distinguishing lies from the truth (“Duped,” The New Yorker, July 2, 2007; “Woman convicted of child abuse hopes fMRI can prove her innocence,” Wired, November 5, 2007), and even what separates “cool” people from “nerds” (“If you secretly like Michael Bolton, we’ll know,” Wired, October 2004). Reports on pathologies such as autism, in which neuroimaging plays a large role, are also common (for - stance, a Time magazine cover story from May 6, 2002, entitled “Inside the world of autism”).
Author: Nicole Lazar
Publisher: Springer Science & Business Media
MRI has emerged as a powerful way of studying in-vivo brain structure and function in both healthy and disease states. Whilst new researchers may be able to call upon advice and support for acquisition from operators, radiologists and technicians, it is more challenging to obtain anunderstanding of the principles of analysing neuroimaging data. This is crucial for choosing acquisition parameters, designing and performing appropriate experiments, and correctly interpreting the results. This primer gives a general and accessible introduction to the wide array of MRI-based neuroimaging methods that are used in research. Supplemented with online datasets and examples to enable the reader to obtain hands-on experience working with real data, it provides a practical and approachableintroduction for those new to the neuroimaging field. The text also covers the fundamentals of what different MRI modalities measure, what artifacts commonly occur, the essentials of the analysis, and common "pipelines" including brain extraction, registration and segmentation. As it does not require any background knowledge beyond high-school mathematics and physics, this primer is essential reading for anyone wanting to work in neuroimaging or grasp the results coming from this rapidly expanding field.The Oxford Neuroimaging Primers are short texts aimed at new researchers or advanced undergraduates from the biological, medical or physical sciences. They are intended to provide a broad understanding of the ways in which neuroimaging data can be analyzed and how that relates to acquisition andinterpretation. Each primer has been written so that it is a stand-alone introduction to a particular area of neuroimaging, and the primers also work together to provide a comprehensive foundation for this increasingly influential field.
Author: Mark Jenkinson,Michael Chappell
Publisher: Oxford University Press
A revealing insider’s account of the power—and limitations—of functional MRI The ability to read minds has long been a fascination of science fiction, but revolutionary new brain-imaging methods are bringing it closer to scientific reality. The New Mind Readers provides a compelling look at the origins, development, and future of these extraordinary tools, revealing how they are increasingly being used to decode our thoughts and experiences—and how this raises sometimes troubling questions about their application in domains such as marketing, politics, and the law. Russell Poldrack takes readers on a journey of scientific discovery, telling the stories of the visionaries behind these breakthroughs. Along the way, he gives an insider’s perspective on what is perhaps the single most important technology in cognitive neuroscience today—functional magnetic resonance imaging, or fMRI, which is providing astonishing new insights into the contents and workings of the mind. He highlights both the amazing power and major limitations of these techniques and describes how applications outside the lab often exceed the bounds of responsible science. Poldrack also details the unique and sometimes disorienting experience of having his own brain scanned more than a hundred times as part of a landmark study of how human brain function changes over time. Written by one of the world’s leading pioneers in the field, The New Mind Readers cuts through the hype and misperceptions surrounding these emerging new methods, offering needed perspective on what they can and cannot do—and demonstrating how they can provide new answers to age-old questions about the nature of consciousness and what it means to be human.
What Neuroimaging Can and Cannot Reveal about Our Thoughts
Author: Russell A. Poldrack
Publisher: Princeton University Press
The second, revised edition of this successful textbook provides an up-to-date description of the use of preoperative fMRI in patients with brain tumors and epilepsies. State of the art fMRI procedures are presented, with detailed consideration of practical aspects, imaging and data processing, normal and pathological findings, and diagnostic possibilities and limitations. Relevant information on brain physiology, functional neuroanatomy, imaging technique, and methodology is provided by recognized experts in these fields. Compared with the first edition, chapters have been updated to reflect the latest developments and in particular the current use of diffusion tensor imaging (DTI) and resting-state fMRI. Entirely new chapters are included on resting-state presurgical fMRI and the role of DTI and tractography in brain tumor surgery. Further chapters address multimodality functional neuroimaging, brain plasticity, and pitfalls, tips, and tricks.
Presurgical Functional Neuroimaging
Author: Christoph Stippich
Fundamentals of Brain Network Analysis is a comprehensive and accessible introduction to methods for unraveling the extraordinary complexity of neuronal connectivity. From the perspective of graph theory and network science, this book introduces, motivates and explains techniques for modeling brain networks as graphs of nodes connected by edges, and covers a diverse array of measures for quantifying their topological and spatial organization. It builds intuition for key concepts and methods by illustrating how they can be practically applied in diverse areas of neuroscience, ranging from the analysis of synaptic networks in the nematode worm to the characterization of large-scale human brain networks constructed with magnetic resonance imaging. This text is ideally suited to neuroscientists wanting to develop expertise in the rapidly developing field of neural connectomics, and to physical and computational scientists wanting to understand how these quantitative methods can be used to understand brain organization. Extensively illustrated throughout by graphical representations of key mathematical concepts and their practical applications to analyses of nervous systems Comprehensively covers graph theoretical analyses of structural and functional brain networks, from microscopic to macroscopic scales, using examples based on a wide variety of experimental methods in neuroscience Designed to inform and empower scientists at all levels of experience, and from any specialist background, wanting to use modern methods of network science to understand the organization of the brain
Author: Alex Fornito,Andrew Zalesky,Edward Bullmore
Publisher: Academic Press
Spontaneous resting-state fluctuations in neuronal activity offer insights into the inherent organization of the human brain, and may provide markers for diagnosis and treatment of mental disorders. Resting state functional magnetic resonance imaging (fMRI) can be used to investigate intrinsicfunctional connectivity networks, which are identified based on similarities in the signal measured from different brain regions.From data acquisition to interpretation of results, Introduction to Resting State fMRI Functional Connectivity discusses a wide range of approaches without requiring any previous knowledge of resting state fMRI, making it highly accessible to readers from a broad range of backgrounds.Supplemented with online datasets and examples to enable the reader to obtain hands-on experience working with real data, this primer provides a practical and approachable introduction for those new to the field of resting state fMRI.The Oxford Neuroimaging Primers are short texts aimed at new researchers or advanced undergraduates from the biological, medical or physical sciences. They are intended to provide a thorough understanding of the ways in which neuroimaging data can be analyzed and how that relates to acquisition andinterpretation. Each primer has been written so that it is a stand-alone introduction to a particular area of neuroimaging, and the primers also work together to provide a comprehensive foundation for this increasingly influential field.
Author: Janine Bijsterbosch,Stephen M. Smith,Christian F. Beckmann
Publisher: Oxford University Press
The Elements of MATLAB Style is a guide for both new and experienced MATLAB programmers. It provides a comprehensive collection of standards and guidelines for creating solid MATLAB code that will be easy to understand, enhance, and maintain. It is written for both individuals and those working in teams in which consistency is critical. This is the only book devoted to MATLAB style and best programming practices, focusing on how MATLAB code can be written in order to maximize its effectiveness. Just as Strunk and White's The Elements of Style provides rules for writing in the English language, this book provides conventions for formatting, naming, documentation, programming and testing. It includes many concise examples of correct and incorrect usage, as well as coverage of the latest language features. The author also provides recommendations on use of the integrated development environment features that help produce better, more consistent software.
Author: Richard K. Johnson
Publisher: Cambridge University Press
In an age where the amount of data collected from brain imaging is increasing constantly, it is of critical importance to analyse those data within an accepted framework to ensure proper integration and comparison of the information collected. This book describes the ideas and procedures that underlie the analysis of signals produced by the brain. The aim is to understand how the brain works, in terms of its functional architecture and dynamics. This book provides the background and methodology for the analysis of all types of brain imaging data, from functional magnetic resonance imaging to magnetoencephalography. Critically, Statistical Parametric Mapping provides a widely accepted conceptual framework which allows treatment of all these different modalities. This rests on an understanding of the brain's functional anatomy and the way that measured signals are caused experimentally. The book takes the reader from the basic concepts underlying the analysis of neuroimaging data to cutting edge approaches that would be difficult to find in any other source. Critically, the material is presented in an incremental way so that the reader can understand the precedents for each new development. This book will be particularly useful to neuroscientists engaged in any form of brain mapping; who have to contend with the real-world problems of data analysis and understanding the techniques they are using. It is primarily a scientific treatment and a didactic introduction to the analysis of brain imaging data. It can be used as both a textbook for students and scientists starting to use the techniques, as well as a reference for practicing neuroscientists. The book also serves as a companion to the software packages that have been developed for brain imaging data analysis. An essential reference and companion for users of the SPM software Provides a complete description of the concepts and procedures entailed by the analysis of brain images Offers full didactic treatment of the basic mathematics behind the analysis of brain imaging data Stands as a compendium of all the advances in neuroimaging data analysis over the past decade Adopts an easy to understand and incremental approach that takes the reader from basic statistics to state of the art approaches such as Variational Bayes Structured treatment of data analysis issues that links different modalities and models Includes a series of appendices and tutorial-style chapters that makes even the most sophisticated approaches accessible
Author: William D. Penny,Karl J. Friston,John T. Ashburner,Stefan J. Kiebel,Thomas E. Nichols
Written specifically for those with no prior programming experience and minimal quantitative training, this accessible text walks behavioral science students and researchers through the process of programming using MATLAB. The book explores examples, terms, and programming needs relevant to those in the behavioral sciences and helps readers perform virtually any computational function in solving their research problems. Principles are illustrated with usable code. Each chapter opens with a list of objectives followed by new commands required to accomplish those goals. These objectives also serve as a reference to help readers easily relocate a section of interest. Sample code and output and chapter problems demonstrate how to write a program and explore a model so readers can see the results obtained using different equations and values. A web site provides solutions to selected problems and the book’s program code output and examples so readers can manipulate them as needed. The outputs on the website have color, motion, and sound. Highlights of the new edition include: •Updated to reflect changes in the most recent version of MATLAB, including special tricks and new functions. •More information on debugging and common errors and more basic problems in the rudiments of MATLAB to help novice users get up and running more quickly. •A new chapter on Psychtoolbox, a suite of programs specifically geared to behavioral science research. •A new chapter on Graphical User Interfaces (GUIs) for user-friendly communication. •Increased emphasis on pre-allocation of memory, recursion, handles, and matrix algebra operators. The book opens with an overview of what is to come and tips on how to write clear programs followed by pointers for interacting with MATLAB, including its commands and how to read error messages. The matrices chapter reviews how to store and access data. Chapter 4 examines how to carry out calculations followed by a review of how to perform various actions depending on the conditions. The chapter on input and output demonstrates how to design programs to create dialogs with users (e.g., participants in studies) and read and write data to and from external files. Chapter 7 reviews the data types available in MATLAB. Readers learn how to write a program as a stand-alone module in Chapter 8. In Chapters 9 and 10 readers learn how to create line and bar graphs or reshape images. Readers learn how to create animations and sounds in Chapter 11. The book concludes with tips on how to use MATLAB with applications such as GUIs and Psychtoolbox. Intended as a primary text for Matlab courses for advanced undergraduate and/or graduate students in experimental and cognitive psychology and/or neuroscience as well as a supplementary text for labs in data (statistical) analysis, research methods, and computational modeling (programming), the book also appeals to individual researchers in these disciplines who wish to get up and running in MATLAB.
Author: David A. Rosenbaum,Jonathan Vaughan,Brad Wyble
Functional Magnetic Resonance Imaging provides a comprehensive introduction to fMRI. The Third Edition has been extensively updated, including a discussion of the physiological basis of fMRI and coverage of ethical and methodological controversies. Example are drawn from both seminal historical work and cutting-edge current research.
Author: Scott A. Huettel,Allen W. Song,Gregory McCarthy
This updated second edition provides the state of the art perspective of the theory, practice and application of modern non-invasive imaging methods employed in exploring the structural and functional architecture of the normal and diseased human brain. Like the successful first edition, it is written by members of the Functional Imaging Laboratory - the Wellcome Trust funded London lab that has contributed much to the development of brain imaging methods and their application in the last decade. This book should excite and intrigue anyone interested in the new facts about the brain gained from neuroimaging and also those who wish to participate in this area of brain science. * Represents an almost entirely new book from 1st edition, covering the rapid advances in methods and in understanding of how human brains are organized * Reviews major advances in cognition, perception, emotion and action * Introduces novel experimental designs and analytical techniques made possible with fMRI, including event-related designs and non-linear analysis
Author: Karl J. Friston,Christopher D. Frith,Raymond J. Dolan,Cathy J. Price,Semir Zeki,John T. Ashburner,William D. Penny
"This book includes state-of-the-art methodologies that introduce biomedical imaging in decision support systems and their applications in clinical practice"--Provided by publisher.
Author: Exarchos, Themis P.
Publisher: IGI Global
Diffusion MRI remains the most comprehensive reference for understanding this rapidly evolving and powerful technology and is an essential handbook for designing, analyzing, and interpreting diffusion MR experiments. Diffusion imaging provides a unique window on human brain anatomy. This non-invasive technique continues to grow in popularity as a way to study brain pathways that could never before be investigated in vivo. This book covers the fundamental theory of diffusion imaging, discusses its most promising applications to basic and clinical neuroscience, and introduces cutting-edge methodological developments that will shape the field in coming years. Written by leading experts in the field, it places the exciting new results emerging from diffusion imaging in the context of classical anatomical techniques to show where diffusion studies might offer unique insights and where potential limitations lie. Fully revised and updated edition of the first comprehensive reference on a powerful technique in brain imaging Covers all aspects of a diffusion MRI study from acquisition through analysis to interpretation, and from fundamental theory to cutting-edge developments New chapters covering connectomics, advanced diffusion acquisition, artifact removal, and applications to the neonatal brain Provides practical advice on running an experiment Includes discussion of applications in psychiatry, neurology, neurosurgery, and basic neuroscience Full color throughout
From Quantitative Measurement to In vivo Neuroanatomy
Author: Heidi Johansen-Berg,Timothy E.J. Behrens
Publisher: Academic Press
The Handbook of Neurolinguistics is a state-of-the-art reference and resource book; it describes current research and theory in the many subfields of neurolinguistics and its clinical application. Thorough and clearly written, the handbook provides an excellent overview of the field of neurolinguistics and its development. The book is organized into five parts covering the history of neurolinguistics, methods in clinical and experimental neurolinguistics, experimental neurolinguistics, clinical neurolinguistics, and resources in neurolinguistics. The first four parts contain a wide range of topics which discuss all important aspects of the many subfields of neurolinguistics. Also included are the relatively new and fast developing areas of research in discourse, pragmatics, and recent neuroimaging techniques. The resources section provides currently available resources, both traditional and modern. The handbook is useful to the newcomer to the field, as well as the expert searching for the latest developments in neurolinguistics. Clearly written and well organized Provides extensive resources Discusses both history and current research Covers the many subfields of neurolinguistics as well the developing areas of research
Author: Harry A. Whitaker,Brigitte Stemmer
Category: Language Arts & Disciplines
Handbook of Neuroemergency Clinical Trials, Second Edition, focuses on the practice of clinical trials in acute neuroscience populations, or what have been called neuroemergencies. Neuroemergencies are complex, life-threatening diseases and disorders, often with devastating consequences, including death or disability. The overall costs are staggering in terms of annual incidence and costs associated with treatment and survival, yet despite their significance as public health issues, there are few drugs and devices available for definitive treatment. The book focuses on novel therapies and the unique challenges their intended targets pose for the design and analysis of clinical trials. This volume provides neurologists, neuroscientists, and drug developers with a more complete understanding of the scientific and medical issues of relevance in designing and initiating clinical development plans for novel drugs intended for acute neuroscience populations. The editors provide the best understanding of the pitfalls associated with acute CNS drug development and the best information on how to approach and solve issues that have plagued drug development. Presents a comprehensive overview on clinical trials and drug development challenges in acute neuroscience populations Provides neurologists, neuroscientists and drug developers with a complete understanding of scientific and medical issues related to designing clinical trials Edited by leaders in the field who have designed and managed over 50 neuroemergency clinical trials
Author: Brett E. Skolnick,Wayne M. Alves
Publisher: Academic Press