Frontiers of Biostatistical Methods and Applications in Clinical Oncology

Author: Shigeyuki Matsui,John Crowley

Publisher: Springer

ISBN: 981100126X

Category: Medical

Page: 438

View: 5031

This book presents the state of the art of biostatistical methods and their applications in clinical oncology. Many methodologies established today in biostatistics have been brought about through its applications to the design and analysis of oncology clinical studies. This field of oncology, now in the midst of evolution owing to rapid advances in biotechnologies and cancer genomics, is becoming one of the most promising disease fields in the shift toward personalized medicine. Modern developments of diagnosis and therapeutics of cancer have also been continuously fueled by recent progress in establishing the infrastructure for conducting more complex, large-scale clinical trials and observational studies. The field of cancer clinical studies therefore will continue to provide many new statistical challenges that warrant further progress in the methodology and practice of biostatistics. This book provides a systematic coverage of various stages of cancer clinical studies. Topics from modern cancer clinical trials include phase I clinical trials for combination therapies, exploratory phase II trials with multiple endpoints/treatments, and confirmative biomarker-based phase III trials with interim monitoring and adaptation. It also covers important areas of cancer screening, prognostic analysis, and the analysis of large-scale molecular data in the era of big data.
Posted in Medical

Frontiers of Statistical Decision Making and Bayesian Analysis

In Honor of James O. Berger

Author: Ming-Hui Chen,Peter Müller,Dongchu Sun,Keying Ye,Dipak K. Dey

Publisher: Springer Science & Business Media

ISBN: 9781441969446

Category: Mathematics

Page: 631

View: 2056

Research in Bayesian analysis and statistical decision theory is rapidly expanding and diversifying, making it increasingly more difficult for any single researcher to stay up to date on all current research frontiers. This book provides a review of current research challenges and opportunities. While the book can not exhaustively cover all current research areas, it does include some exemplary discussion of most research frontiers. Topics include objective Bayesian inference, shrinkage estimation and other decision based estimation, model selection and testing, nonparametric Bayes, the interface of Bayesian and frequentist inference, data mining and machine learning, methods for categorical and spatio-temporal data analysis and posterior simulation methods. Several major application areas are covered: computer models, Bayesian clinical trial design, epidemiology, phylogenetics, bioinformatics, climate modeling and applications in political science, finance and marketing. As a review of current research in Bayesian analysis the book presents a balance between theory and applications. The lack of a clear demarcation between theoretical and applied research is a reflection of the highly interdisciplinary and often applied nature of research in Bayesian statistics. The book is intended as an update for researchers in Bayesian statistics, including non-statisticians who make use of Bayesian inference to address substantive research questions in other fields. It would also be useful for graduate students and research scholars in statistics or biostatistics who wish to acquaint themselves with current research frontiers.
Posted in Mathematics

Applied Surrogate Endpoint Evaluation Methods with SAS and R

Author: Ariel Alonso,Theophile Bigirumurame,Tomasz Burzykowski,Marc Buyse,Geert Molenberghs,Leacky Muchene,Nolen Joy Perualila,Ziv Shkedy,Wim Van der Elst

Publisher: CRC Press

ISBN: 1315355361

Category: Mathematics

Page: 396

View: 5596

An important factor that affects the duration, complexity and cost of a clinical trial is the endpoint used to study the treatment’s efficacy. When a true endpoint is difficult to use because of such factors as long follow-up times or prohibitive cost, it is sometimes possible to use a surrogate endpoint that can be measured in a more convenient or cost-effective way. This book focuses on the use of surrogate endpoint evaluation methods in practice, using SAS and R.
Posted in Mathematics

Advances in Statistical Methods for the Health Sciences

Applications to Cancer and AIDS Studies, Genome Sequence Analysis, and Survival Analysis

Author: Jean-Louis Auget,N. Balakrishnan,Mounir Mesbah,Geert Molenberghs

Publisher: Springer Science & Business Media

ISBN: 9780817645427

Category: Mathematics

Page: 540

View: 1379

Statistical methods have become an increasingly important and integral part of research in the health sciences. Many sophisticated methodologies have been developed for specific applications and problems. This self-contained comprehensive volume covers a wide range of topics pertaining to new statistical methods in the health sciences, including epidemiology, pharmacovigilance, quality of life, survival analysis, and genomics. The book will serve the health science community as well as practitioners, researchers, and graduate students in applied probability, statistics, and biostatistics.
Posted in Mathematics

Statistical Advances in the Biomedical Sciences

Clinical Trials, Epidemiology, Survival Analysis, and Bioinformatics

Author: Atanu Biswas,Sujay Datta,Jason P. Fine,Mark R. Segal

Publisher: John Wiley & Sons

ISBN: 9780470181195

Category: Mathematics

Page: 616

View: 7091

The Most Comprehensive and Cutting-Edge Guide to Statistical Applications in Biomedical Research With the increasing use of biotechnology in medical research and the sophisticated advances in computing, it has become essential for practitioners in the biomedical sciences to be fully educated on the role statistics plays in ensuring the accurate analysis of research findings. Statistical Advances in the Biomedical Sciences explores the growing value of statistical knowledge in the management and comprehension of medical research and, more specifically, provides an accessible introduction to the contemporary methodologies used to understand complex problems in the four major areas of modern-day biomedical science: clinical trials, epidemiology, survival analysis, and bioinformatics. Composed of contributions from eminent researchers in the field, this volume discusses the application of statistical techniques to various aspects of modern medical research and illustrates how these methods ultimately prove to be an indispensable part of proper data collection and analysis. A structural uniformity is maintained across all chapters, each beginning with an introduction that discusses general concepts and the biomedical problem under focus and is followed by specific details on the associated methods, algorithms, and applications. In addition, each chapter provides a summary of the main ideas and offers a concluding remarks section that presents novel ideas, approaches, and challenges for future research. Complete with detailed references and insight on the future directions of biomedical research, Statistical Advances in the Biomedical Sciences provides vital statistical guidance to practitioners in the biomedical sciences while also introducing statisticians to new, multidisciplinary frontiers of application. This text is an excellent reference for graduate- and PhD-level courses in various areas of biostatistics and the medical sciences and also serves as a valuable tool for medical researchers, statisticians, public health professionals, and biostatisticians.
Posted in Mathematics

Recent Advances in Biostatistics

False Discovery Rates, Survival Analysis, and Related Topics

Author: Manish Bhattacharjee,Sunil K. Dhar,Sundarraman Subramanian

Publisher: World Scientific

ISBN: 9814329797

Category: Medical

Page: 292

View: 3700

This unique volume provides self-contained accounts of some recent trends in Biostatistics methodology and their applications. It includes state-of-the-art reviews and original contributions. The articles included in this volume are based on a careful selection of peer-reviewed papers, authored by eminent experts in the field, representing a well balanced mix of researchers from the academia, R&D sectors of government and the pharmaceutical industry. The book is also intended to give advanced graduate students and new researchers a scholarly overview of several research frontiers in biostatistics, which they can use to further advance the field through development of new techniques and results.
Posted in Medical

Research Report

Author: N.A

Publisher: N.A

ISBN: N.A

Category: Cancer

Page: N.A

View: 6713

Posted in Cancer

Statistical Analysis of Proteomics, Metabolomics, and Lipidomics Data Using Mass Spectrometry

Author: Susmita Datta,Bart J. A. Mertens

Publisher: Springer

ISBN: 3319458094

Category: Medical

Page: 295

View: 4358

This book presents an overview of computational and statistical design and analysis of mass spectrometry-based proteomics, metabolomics, and lipidomics data. This contributed volume provides an introduction to the special aspects of statistical design and analysis with mass spectrometry data for the new omic sciences. The text discusses common aspects of design and analysis between and across all (or most) forms of mass spectrometry, while also providing special examples of application with the most common forms of mass spectrometry. Also covered are applications of computational mass spectrometry not only in clinical study but also in the interpretation of omics data in plant biology studies. Omics research fields are expected to revolutionize biomolecular research by the ability to simultaneously profile many compounds within either patient blood, urine, tissue, or other biological samples. Mass spectrometry is one of the key analytical techniques used in these new omic sciences. Liquid chromatography mass spectrometry, time-of-flight data, and Fourier transform mass spectrometry are but a selection of the measurement platforms available to the modern analyst. Thus in practical proteomics or metabolomics, researchers will not only be confronted with new high dimensional data types—as opposed to the familiar data structures in more classical genomics—but also with great variation between distinct types of mass spectral measurements derived from different platforms, which may complicate analyses, comparison, and interpretation of results.
Posted in Medical

Statistical Analysis of Next Generation Sequencing Data

Author: Somnath Datta,Dan Nettleton

Publisher: Springer

ISBN: 3319072129

Category: Medical

Page: 432

View: 1516

Next Generation Sequencing (NGS) is the latest high throughput technology to revolutionize genomic research. NGS generates massive genomic datasets that play a key role in the big data phenomenon that surrounds us today. To extract signals from high-dimensional NGS data and make valid statistical inferences and predictions, novel data analytic and statistical techniques are needed. This book contains 20 chapters written by prominent statisticians working with NGS data. The topics range from basic preprocessing and analysis with NGS data to more complex genomic applications such as copy number variation and isoform expression detection. Research statisticians who want to learn about this growing and exciting area will find this book useful. In addition, many chapters from this book could be included in graduate-level classes in statistical bioinformatics for training future biostatisticians who will be expected to deal with genomic data in basic biomedical research, genomic clinical trials and personalized medicine. About the editors: Somnath Datta is Professor and Vice Chair of Bioinformatics and Biostatistics at the University of Louisville. He is Fellow of the American Statistical Association, Fellow of the Institute of Mathematical Statistics and Elected Member of the International Statistical Institute. He has contributed to numerous research areas in Statistics, Biostatistics and Bioinformatics. Dan Nettleton is Professor and Laurence H. Baker Endowed Chair of Biological Statistics in the Department of Statistics at Iowa State University. He is Fellow of the American Statistical Association and has published research on a variety of topics in statistics, biology and bioinformatics.
Posted in Medical

Frontiers in Computational and Systems Biology

Author: Jianfeng Feng,Wenjiang Fu,Fengzhu Sun

Publisher: Springer Science & Business Media

ISBN: 9781849961967

Category: Science

Page: 24

View: 2634

Biological and biomedical studies have entered a new era over the past two decades thanks to the wide use of mathematical models and computational approaches. A booming of computational biology, which sheerly was a theoretician’s fantasy twenty years ago, has become a reality. Obsession with computational biology and theoretical approaches is evidenced in articles hailing the arrival of what are va- ously called quantitative biology, bioinformatics, theoretical biology, and systems biology. New technologies and data resources in genetics, such as the International HapMap project, enable large-scale studies, such as genome-wide association st- ies, which could potentially identify most common genetic variants as well as rare variants of the human DNA that may alter individual’s susceptibility to disease and the response to medical treatment. Meanwhile the multi-electrode recording from behaving animals makes it feasible to control the animal mental activity, which could potentially lead to the development of useful brain–machine interfaces. - bracing the sheer volume of genetic, genomic, and other type of data, an essential approach is, ?rst of all, to avoid drowning the true signal in the data. It has been witnessed that theoretical approach to biology has emerged as a powerful and st- ulating research paradigm in biological studies, which in turn leads to a new - search paradigm in mathematics, physics, and computer science and moves forward with the interplays among experimental studies and outcomes, simulation studies, and theoretical investigations.
Posted in Science

Translational Bioinformatics and Its Application

Author: Dong-Qing Wei,Yilong Ma,William C.S. Cho,Qin Xu,Fengfeng Zhou

Publisher: Springer

ISBN: 9402410457

Category: Science

Page: 437

View: 6933

This book offers a detailed overview of translational bioinformatics together with real-case applications. Translational bioinformatics integrates the areas of basic bioinformatics, clinical informatics, statistical genetics and informatics in order to further our understanding of the molecular basis of diseases. By analyzing voluminous amounts of molecular and clinical data, it also provides clinical information, which can then be applied. Filling the gap between clinic research and informatics, the book is a valuable resource for human geneticists, clinicians, health educators and policy makers, as well as graduate students majoring in biology, biostatistics, and bioinformatics.
Posted in Science

Frontier and Future Development of Information Technology in Medicine and Education

ITME 2013

Author: Shaozi Li,Qun Jin,Xiaohong Jiang,James J. (Jong Hyuk) Park

Publisher: Springer Science & Business Media

ISBN: 9400776187

Category: Technology & Engineering

Page: 3581

View: 1637

IT changes everyday’s life, especially in education and medicine. The goal of ITME 2013 is to further explore the theoretical and practical issues of IT in education and medicine. It also aims to foster new ideas and collaboration between researchers and practitioners.
Posted in Technology & Engineering

Amstat News

Author: N.A

Publisher: N.A

ISBN: N.A

Category: Statistics

Page: N.A

View: 1626

Posted in Statistics

Radiation Physics for Nuclear Medicine

Author: Marie Claire Cantone,Christoph Hoeschen

Publisher: Springer Science & Business Media

ISBN: 9783642113277

Category: Medical

Page: 285

View: 1193

The field of nuclear medicine is expanding rapidly, with the development of exciting new diagnostic methods and treatments. This growth is closely associated with significant advances in radiation physics. In this book, acknowledged experts explain the basic principles of radiation physics in relation to nuclear medicine and examine important novel approaches in the field. The first section is devoted to what might be termed the "building blocks" of nuclear medicine, including the mechanisms of interaction between radiation and matter and Monte Carlo codes. In subsequent sections, radiation sources for medical applications, radiopharmaceutical development and production, and radiation detectors are discussed in detail. New frontiers are then explored, including improved algorithms for image reconstruction, biokinetic models, and voxel phantoms for internal dosimetry. Both trainees and experienced practitioners and researchers will find this book to be an invaluable source of up-to-date information.
Posted in Medical

Data mining

praktische Werkzeuge und Techniken für das maschinelle Lernen

Author: Ian H. Witten,Eibe Frank

Publisher: N.A

ISBN: 9783446215337

Category:

Page: 386

View: 8085

Posted in

Frontiers in Radiation Biology

Proceedings of the 21st Annual Meeting of the European Society for Radiation Biology, Tel Aviv, October 1988

Author: Emanuel Riklis

Publisher: John Wiley & Sons

ISBN: N.A

Category: Radiation

Page: 712

View: 6553

Recent events have shown the harmful effects of radiation and the possible spread-area of radioactive contaminants in the environment. Nevertheless, the use of radiation in treating cancer has widened to include more types of radiation and heavy ions to improve results with radioprotective and radiosensitizing compounds. These proceedings cover a wide scope of topics ranging from radiotherapy, radiation carcinogenesis and radiation protection to the impact of radiation on the environment. They provide both an indispensable state-of-the-art report and a stimulating discussion of important developments in this exciting field of research.
Posted in Radiation