Chemical Aspects of Biosynthesis

Author: John Mann

Publisher: Oxford University Press on Demand

ISBN: 9780198556763

Category: Language Arts & Disciplines

Page: 92

View: 4402

This introductory text describes and explains the chemistry involved in the biosynthesis of secondary metabolites. The book emphasizes the pharmacological and toxicological significance of the compounds, and the final chapter reviews their ecological role. Suggestions for further reading are provided.
Posted in Language Arts & Disciplines

Pericyclic Reactions

Author: Ian Fleming

Publisher: Oxford University Press, USA

ISBN: 0199680906

Category: Addition reactions

Page: 118

View: 1681

Key texts in the renowned Oxford Chemistry Primers series have been fully refreshed and updated to suit the needs of today's students, lecturers, and postgraduate researchers. The rigorous and yet accessible treatment of each subject area is ideal for those wanting to know more about a particular topic not covered comprehensively in existing undergraduate texts. Moreover, cutting-edge examples and applications throughout the texts show the relevance of thechemistry being described to the real world. Pericyclic reactions constitute a fundamental class of organic chemistry, including such commercially important synthetic reactions as theDiels-Alder reaction. This primer gives a concise and accessible account of these reactions, enabling students to recognise the different types of pericyclic reaction and understand their application in organic synthesis.
Posted in Addition reactions

The Organic Chemistry of Sugars

Author: Daniel E. Levy,Péter Fügedi

Publisher: CRC Press

ISBN: 9781420027952

Category: Science

Page: 904

View: 4044

Intrigued as much by its complex nature as by its outsider status in traditional organic chemistry, the editors of The Organic Chemistry of Sugars compile a groundbreaking resource in carbohydrate chemistry that illustrates the ease at which sugars can be manipulated in a variety of organic reactions. Each chapter contains numerous examples demonstrating the methods and strategies that apply mainstream organic chemistry to the chemical modification of sugars. The book first describes the discovery, development, and impact of carbohydrates, followed by a discussion of protecting group strategies, glycosylation techniques, and oligosaccharide syntheses. Several chapters focus on reactions that convert sugars and carbohydrates to non-carbohydrate molecules including the substitution of sugar hydroxyl groups to new groups of synthetic or biological interest, cyclitols and carbasugars, as well as endocyclic heteroatom substitutions. Subsequent chapters demonstrate the use of sugars in chiral catalysis, their roles as convenient starting materials for complex syntheses involving multiple stereogenic centers, and syntheses for monosaccharides. The final chapters focus on new and emerging technologies, including approaches to combinatorial carbohydrate chemistry, the biological importance and chemical synthesis of glycopeptides, and the medicinally significant concept of glycomimetics. Presenting the organic chemistry of sugars as a solution to many complex synthetic challenges, The Organic Chemistry of Sugars provides a comprehensive treatment of the manipulation of sugars and their importance in mainstream organic chemistry. Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.
Posted in Science

Practical Process Research and Development

Author: Neal G. Anderson

Publisher: Elsevier

ISBN: 0080514480

Category: Science

Page: 354

View: 7831

This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students. Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Includes over 100 tips for rapid process development Presents guidelines for implementing and troubleshooting processes
Posted in Science

Reactive Intermediates

Author: Christopher J. Moody,Gordon Harlow Whitham

Publisher: Oxford University Press on Demand

ISBN: 9780198556725

Category: Science

Page: 89

View: 7512

Neutral reactive intermediates -- radicals, carbenes, nitrenes, and aryenes -- occupy a fascinating place in the history of organic chemistry. First regarded as mere curiosities, neutral reactive intermediates ultimately came under the intense scrutiny of physical organic chemists from a mechanistic point-of-view. This concise text concentrates on how these electron-deficient species now play a key role in synthetic chemistry research. Important reactions are clearly and simply laid out with carefully chosen examples that illustrate their use in organic synthesis. Each chapter includes problems as well as suggestions for further reading. Undergraduates will find Reactive Intermediates an invaluable summary of this important topic in organic chemistry--one that fills a gap created by the superficial treatment accorded these valuable compounds in most chemistry textbooks.
Posted in Science

Organometallic Reagents in Synthesis

Author: Paul R. Jenkins

Publisher: Oxford University Press on Demand

ISBN: 9780198556664

Category: Science

Page: 91

View: 7124

This straightforward introduction looks at the properties and reactions of main group organometallic compounds, placing particular emphasis on their applications in synthesis. The book adopts a logical approach to this important area of organic chemistry, providing the student with a clear account of all aspects of the field.
Posted in Science

Foundations of Spectroscopy

Author: Simon B. Duckett,Bruce C. Gilbert

Publisher: Oxford University Press

ISBN: 9780198503354

Category: Language Arts & Disciplines

Page: 90

View: 1503

This Primer covers the foundations of spectroscopy at a level suitable for first year chemistry undergraduates. Mass spectrometry, and X-ray diffraction, along with traditional spectroscopic techniques: i.r., n.m.r. and u.v. -visible spectroscopy are covered. The essential physical principles of each method are introduced, and many examples of spectral analysis provided. Problems, and further reading are also included. This Primer is designed to reflect the recent advances in the use of spectroscopic and diffraction methods, not only for obtaining an analysis of elements and groups present in a molecule but also for establishing the arrangement of the constituent atoms. These developments have had a profound effect by increasing scientific knowledge in the fields of chemistry and molecular biology, reflected in the elucidation of the structure and function of a wide range of compounds including drugs, proteins and enzymes, and nucleic acids.
Posted in Language Arts & Disciplines

Photochemistry of Organic Compounds

From Concepts to Practice

Author: Petr Klán,Jakob Wirz

Publisher: John Wiley & Sons

ISBN: 1405190884

Category: Science

Page: 563

View: 956

This new volume in the Postgraduate Chemistry Series provides a thorough overview of the principles and uses of synthetic organic photochemistry. Appropriate at postgraduate and research level it will also serve as a reference for more experienced workers.
Posted in Science

Fundamentals of Asymmetric Catalysis

Author: Patrick J. Walsh,Marisa C. Kozlowski

Publisher: University Science Books

ISBN: 9781891389542

Category: Science

Page: 674

View: 5854

The field of asymmetric catalysis plays an increasingly large role in chemical synthesis as the demand for single-enantiomer starting materials, intermediates, and products rises. This book describes the essential aspects of enantioselective catalysis in a clear, logical fashion, with chapters organized by concept rather than by reaction type. Each concept is supported by carefully selected examples to give the reader broad exposure to a wide range of catalysts, reactions, and reaction mechanisms.
Posted in Science

Oxford Textbook of Medicine

Author: D. A. Warrell,Timothy M. Cox,John D. Firth

Publisher: N.A

ISBN: 9780198570141

Category: Internal medicine

Page: 1602

View: 7115

Posted in Internal medicine

Radical Chemistry

Author: Michael John Perkins

Publisher: Prentice Hall

ISBN: 9780133209204

Category: Science

Page: 182

View: 9437

This text explains the methodology and basic ideas of radical chemistry at third year undergraduate level, and shows how these ideas have on the one hand been developed into powerful tools in the workshops of synthetic organic chemists, and on the other have given new insights into biological chemistry and disease.
Posted in Science

Fundamentals of Pharmacognosy and Phytotherapy E-Book

Author: Michael Heinrich,Joanne Barnes,Jose Prieto-Garcia,Simon Gibbons,Elizabeth M. Williamson

Publisher: Elsevier Health Sciences

ISBN: 0702070068

Category: Medical

Page: 352

View: 7917

Pharmacognosy (the science of biogenic or nature-derived pharmaceuticals and poisons) has been an established basic pharmaceutical science taught in institutions of pharmacy education for over two centuries. Over the past 20 years though it has become increasingly important given the explosion of new drugs, phytomedicines (plant medicines), nutraceuticals and dietary supplements – all of which need to be fully understood, tested and regulated. From a review of the previous edition: ‘Drawing on their wealth of experience and knowledge in this field, the authors, who are without doubt among the finest minds in pharmacognosy today, provide useful and fascinating insights into the history, botany, chemistry, phytotherapy and importance of medicinal plants in some of today’s healthcare systems. This is a landmark textbook, which carefully brings together relevant data from numerous sources and provides, in an authoritative and exhaustive manner, cutting-edge information that is relevant to pharmacists, pharmacognocists, complementary practitioners, doctors and nurses alike.’ The Pharmaceutical Journal ‘This is an excellent text book which provides fascinating insights into the world of pharmacognosy and the authors masterfully integrated elements of orthodox pharmacognosy and phytotherapy. Both the science student and the non-scientific person interested in phytotherapy will greatly benefit from reading this publication. It is comprehensive, easy to follow and after having read this book, one is so much more aware of the uniqueness of phytomedicines. A must read for any healthcare practitioner.’ Covers the history, biology and chemistry of plant-based medicines Covers pharmaceutical and neutraceuticals derived from plants Covers the role of medicinal plants in worldwide healthcare systems Examines the therapeutics and evidence of plant-based medicines by body system Sections on regulatory information expanded New evidence updates throughout New material covering non-medical supplements Therapeutics updated throughout Now on StudentConsult
Posted in Medical

Essentials of Carbohydrate Chemistry and Biochemistry

Author: Thisbe K. Lindhorst

Publisher: Wiley-VCH

ISBN: 9783527315284

Category: Science

Page: 332

View: 6364

Concise yet complete, this is a succinct introduction to the topic, covering both basic chemistry as well as such advanced topics as high-throughput analytics and glycomics -- in one handy volume. This improved and expanded 3rd edition features all-new material on combinatorial synthesis of carbohydrates and carbohydrate biodiversity, and each chapter now contains study questions for self-learning and classroom teaching. Didactically written by an experienced lecturer and graduate student advisor, the text is backed by practical examples and more than 150 study questions tailored to students' needs.
Posted in Science

Strategic Applications of Named Reactions in Organic Synthesis

Author: Laszlo Kurti,Barbara Czako

Publisher: Elsevier

ISBN: 0080575412

Category: Science

Page: 864

View: 6646

Kurti and Czako have produced an indispensable tool for specialists and non-specialists in organic chemistry. This innovative reference work includes 250 organic reactions and their strategic use in the synthesis of complex natural and unnatural products. Reactions are thoroughly discussed in a convenient, two-page layout--using full color. Its comprehensive coverage, superb organization, quality of presentation, and wealth of references, make this a necessity for every organic chemist. * The first reference work on named reactions to present colored schemes for easier understanding * 250 frequently used named reactions are presented in a convenient two-page layout with numerous examples * An opening list of abbreviations includes both structures and chemical names * Contains more than 10,000 references grouped by seminal papers, reviews, modifications, and theoretical works * Appendices list reactions in order of discovery, group by contemporary usage, and provide additional study tools * Extensive index quickly locates information using words found in text and drawings
Posted in Science

Organocatalysis

Author: Manfred Reetz,Benjamin List,Stefan Jaroch,Hilmar Weinmann

Publisher: Springer Science & Business Media

ISBN: 9783540734956

Category: Science

Page: 342

View: 7845

This book provides an excellent overview on state-of-the-art of modern organocatalysis. It presents the contributions from leading experts, with backgrounds in academia and industry, to an Ernst Schering Research Foundation Symposium held in April 2007. It will be of interest to those who want a general overview of the topic, but also to those who want to learn more about the state-of-the-art, current trends and perspectives in this highly dynamic field of research.
Posted in Science

Principles of Process Research and Chemical Development in the Pharmaceutical Industry

Author: Oljan Repic

Publisher: Wiley-Interscience

ISBN: 9780471165163

Category: Science

Page: 240

View: 3222

This text discusses the functions of Process R&D (research and development), which involves the method of transforming a research synthetic procedure into a plant process and the key aspects of a synthesis that must be considered when scaling up a process. Topics consist of: basic principles of chemical development; techniques for the minimization of by-product impurities; criteria for cost-effective synthesis of enantiopure compounds by resolutions; asymmetric synthesis, and "chiral pool" strategy; synthesis for labeling substances with hydrogen or carbon isotopes; and last, licensing.
Posted in Science

Inorganic Chemistry in Biology

Author: Patricia C. Wilkins

Publisher: Oxford University Press, USA

ISBN: N.A

Category: Science

Page: 91

View: 9851

Providing a good starting survey of the field, this book emphasizes the importance of inorganic chemistry in biological systems. The basic background of the interactions of atoms, molecules and especially metal ions, with biomolecules covers about a quarter of the book. The remainder discusses the biologically important elements, and their occurrence and functions in biomaterials - these are illustrated by certain roles in humans, fishes, beetles, and plants and in varied human diseases,such as cystic fibrosis methemoglobemia, and thalassemia. This upper level undergraduate textbook for students of chemistry and biology is the only current short book covering, briefly, most areas of bioinorganic chemistry.
Posted in Science

Introduction to Molecular Symmetry

Author: J. S. Ogden

Publisher: Oxford University Press on Demand

ISBN: 9780198559108

Category: Science

Page: 90

View: 4227

This Primer presents an introduction to molecular symmetry and point groups with an emphasis on their applications. The author has adopted a non-mathematical approach as far as possible and the text will supplement those that are too advanced or gloss over important information. Chapter topics include symmetry elements, operations and point groups; matrices, multiplications tables and representations; the reduction formula; molecular vibrations; vibrational spectroscopy and degenerate vibrations; symmetry aspects of chemical bonding and matrices in higher order point groups
Posted in Science