Cell Signaling

principles and mechanisms

Author: Wendell Lim,Bruce Mayer,Tony Pawson

Publisher: Taylor & Francis

ISBN: 1317573625

Category: Science

Page: 416

View: 8116

Cell Signaling presents the principles and components that underlie all known signaling processes. It provides undergraduate and graduate students the conceptual tools needed to make sense of the dizzying array of pathways used by the cell to communicate. By emphasizing the common design principles, components, and logic that drives all signaling, the book develops a conceptual framework through which students can understand how thousands of diverse signaling proteins interact with each other in vast interconnected networks. The book first examines the common currencies of cellular information processing and the core components of the signaling machinery. It then shows how these individual components link together into networks and pathways to perform more sophisticated tasks. Many specific examples are provided throughout to illustrate common principles, and provide a comprehensive overview of major eukaryotic signaling pathways.
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Cell Signaling Reactions

Single-Molecular Kinetic Analysis

Author: Yasushi Sako,Masahiro Ueda

Publisher: Springer Science & Business Media

ISBN: 9789048198641

Category: Medical

Page: 330

View: 5094

This book encompasses the exciting developments and challenges in the fast-moving and rapidly expanding research field of single-molecule kinetic analysis of cell signaling that promises to be one of the most significant and exciting areas of biological research for the foreseeable future. Cell signaling is carried out by complicated reaction networks of macromolecules, and single-molecule analyses has already demonstrated its power to unravel complex reaction dynamics in purified systems. To date, most of the published research in the field of single-molecule processes in cells, focus on the dynamic properties (translational movements of the centre of mass) of biological molecules. However, we hope that this book presents as many kinetic analyses of cell signaling as possible. Although single-molecule kinetic analysis of cellular systems is a relatively young field when compared with the analysis of single-molecule movements in cells, this type of analysis is highly important because it directly relates to the molecular functions that control cellular behavior and in the future, single-molecule kinetic analysis will be largely directed towards cellular systems. Thus, we hope that this book will be of interest to all those working in the fields of molecular and cell biology, as well as biophysics and biochemistry.
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Handbook of Cell Signaling

Author: Ralph A. Bradshaw,Edward A. Dennis

Publisher: Academic Press

ISBN: 0080920918

Category: Science

Page: 3048

View: 9831

KEY FEATURES: * Contains over 350 chapters of comprehensive coverage on cell signaling * Includes discussion on topics from ligand/receptor interactions to organ/organism responses * Provides user-friendly, well-illustrated, reputable content by experts in the field DESCRIPTION: Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors.
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Intercellular Signaling in Development and Disease

Author: Edward A. Dennis,Ralph A. Bradshaw

Publisher: Academic Press

ISBN: 0123822157

Category: Science

Page: 532

View: 7056

"Cell signaling, which is also often referred to as signal transduction or, in more specialized cases, transmembrane signaling, is the process by which cells communicate with their environment and respond temporally to external cues that they sense there. All cells have the capacity to achieve this to some degree, albeit with a wide variation in purpose, mechanism, and response. At the same time, there is a remarkable degree of similarity over quite a range of species, particularly in the eukaryotic kingdom, and comparative physiology has been a useful tool in the development of this field. The central importance of this general phenomenon (sensing of external stimuli by cells) has been appreciated for a long time, but it has truly become a dominant part of cell and molecular biology research in the past three decades, in part because a description of the dynamic responses of cells to external stimuli is, in essence, a description of the life process itself. This approach lies at the core of the developing fields of proteomics and metabolomics, and its importance to human and animal health is already plainly evident"--Provided by publisher.
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Lipidomics and Bioactive Lipids: Lipids and Cell Signaling

Author: N.A

Publisher: Elsevier

ISBN: 9780080554099

Category: Science

Page: 392

View: 2138

This volume in the well-established Methods in Enzymology series features methods for the study of lipids using mass spectrometry techniques. Articles in this volume cover topics such as Phospholipase A1 assays using a radio-labeled substrate and mass spectrometry; Real-time Cell Assays of Phospholipases A2 Using Fluorogenic Phospholipids; Analysis and Pharmacological Targeting of Phospholipase C â interactions with G proteins; Biochemical Analysis of Phospholipase D.; Measurement of Autotaxin/Lysophospholipase D Activity; Platelet-Activating Factor; Quantitative measurement of PtdIns(3,4,5)P3; Measuring Phosphorylated Akt And Other Phosphoinositide 3-Kinase-Regulated Phosphoproteins In Primary Lymphocytes; Regulation of Phosphatidylinositol 4-Phosphate 5-Kinase activity by partner proteins; Biochemical Analysis of Inositol Phosphate Kinases; Analysis of the phosphoinositides and their aqueous metabolites; Combination of C17-sphingoid base homologues and mass spectrometry analysis as a new approach to study sphingolipid metabolism; Measurement of mammalian sphingosine-1-phosphate phosphohydrolase activity in vitro and in vivo; A rapid and sensitive method to measure secretion of sphingosine-1-phosphate; Ceramide Kinase and Ceramide-1-Phosphate; Measurement of Mammalian Diacylglycerol Kinase Activity in vitro and in Cells; Lipid Phosphate Phosphatases from Saccharomyces cerevisiae.
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Cell Signalling

Author: John T. Hancock

Publisher: Oxford University Press

ISBN: 019965848X

Category: Science

Page: 456

View: 1001

Signalling within and between cells is one of the most important aspects of modern biochemistry and cell biology. An understanding of signalling pathways is vital to a wide range of biologists, from those who are investigating the causes of cancer, to those who are concerned about the impactof environmental pollutants on the ecosystem. The way cells adapt to changing environments, and the way cell dysfunction causes disease, is underpinned by cell signalling events. Cell Signalling presents a carefully structured and highly accessible introduction to this intricate and rapidly growing field. Starting with an overview of cell signalling and highlighting its importance in many biological systems, the book goes on to explore the key components of extracellular andintracellular signalling mechanisms, before examining how these components come together to create signalling pathways. A focus on common components and concepts, rather than mechanistic detail, allows the reader to gain a thorough understanding of the principles that underpin cell signalling. Online Resource CentreThe Online Resource Centre to accompany Cell Signalling features:For students:* Links to useful websitesFor registered adopters of the text:* Journal Clubs: suggested research papers and discussion questions linked to topics featured in the book* Figures from the book in electronic format for use in lectures
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Nitric Oxide, Cell Signaling, and Gene Expression

Author: Santiago Lamas

Publisher: CRC Press

ISBN: 1420027166

Category: Science

Page: 456

View: 1971

Since the nineteenth century, when engineers were using nitroglycerin to blow up rockbeds, and doctors were prescribing it to relieve angina, scientists have been exploring the incredible and often baffling behavior of nitric oxide. In the 1980s, researchers discovered that nitric oxide had the capacity to regulate vascular tone through cyclic GMP, firmly establishing its role as a physiological mediator. Over the last ten years, still further roles have been discovered that relate to nitric oxide’s unique ability to interact with and modify a wide variety of other molecules and regulators including glutathione, as well as macromolecules such as DNA and proteins. Nitric Oxide, Cell Signaling, and Gene Expression is the first comprehensive work to showcase the highly useful diversity of cellular effects elicited by nitric oxide. A collection of expert contributors provides cutting-edge information on a variety of topics with tremendous implications in the fields of biology and medicine. These include... Nitric oxide-driven cell signaling mediated by cGMP, GTPases, and S-nitrosylation Nitric oxide’s role in hypoxia, gene expression, post-transcriptional control of gene expression, gene regulation in pulmonary pathophysiology, and tumor biology The intriguing concept of mitochondrial nitric oxide synthase as a regulator of mitochondrial bioenergetics and free radical production Modulation of cell metabolism Nitric Oxide, Cell Signaling, and Gene Expression offers cell and molecular biologists, pharmacologists, biochemists, and biomedical researchers, as well as advanced graduate students, the insight and information they need to understand recent developments in this highly fertile area of research.
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Sphingolipid Metabolism and Cell Signaling

Author: Alfred H. Merrill,Yusuf A. Hannun

Publisher: Academic Press

ISBN: 0121822133

Category: Medical

Page: 648

View: 8738

This volume contains information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets. Its companion Volume 311 presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
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Dietary Modulation of Cell Signaling Pathways

Author: Zigang Dong,Young-Joon Surh

Publisher: CRC Press

ISBN: 9780849381492

Category: Science

Page: 504

View: 4089

A consequence of rapid progress in the science of nutrigenomics and nutrigenetics is the substantial accumulation of data covering nutrienal modulation of gene expression at the cellular and subcellular levels. Current research is increasingly focused on the role of nutrition and diet in modifying oxidative damage in the progression of disease. Dietary Modulation of Cell Signaling Pathways reviews some of these findings, focusing on nutrient-gene interactions with particular emphasis on the intracellular signaling network. Explore a Pivotal Function for Maintaining Homeostasis The book addresses the dietary modulation of particular gene expression systems and highlights the underlying molecular and cellular mechanisms that involve upstream signaling molecules, such as kinases and transcription factors in the context of their therapeutic potential. It describes nutrients’ actions on the activation of an antioxidant and inflammatory transcription factor and the induction of their target gene expression. Provides a Mechanistic Understanding of the Action of Dietary Components Comprehensively covering dietary modulation of cell signaling, leading experts provide information on state-of-the-art research in their own specialty. For those working in the fields of dietary components, molecular mechanisms, and health benefits, this book presents a useful tool for mechanistic understanding of the action of dietary components.
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Natural Compounds and Their Role in Apoptotic Cell Signaling Pathways

Author: Marc Diederich

Publisher: John Wiley & Sons

ISBN: 1573317373

Category: Science

Page: 400

View: 520

"This volume includes contributions about the effect of natural compounds on cancer cells as well as on neurodegenerative diseases. More specifically, natural compounds are also described as inducers of cell death. Topics related to diet in health, disease, and inflammation linked to cancer are also discussed."--Pref.
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Cell-Cell Signaling in Vertebrate Development

Author: E.J. Robertson

Publisher: Academic Press

ISBN: 0323157750

Category: Science

Page: 284

View: 3734

Cell-Cell Signaling in Vertebrate Development provides a comprehensive discussion of cell-cell interactions in vertebrate development and the molecular signals that mediate them. The book is divided into six parts, arranged according to major developmental phenomena demonstrated in illustrative systems derived from amphibian, avian, mammalian, and piscine sources. Part I introduces the mechanisms of gene activation in the context of early vertebrate development. Part II is concerned with cellular contacts and the induction process. Cell-cell interactions are illustrated through analyses of neurogenesis in the mouse; embryonic induction is considered in the frog and in the chick. Part III deals with cell migration and differentiation. It examines cell lineages in the frog eyebud; migration phenomena in connection with axon guidance in the embryonic rat spinal cord and mouse visual system; pathfinding by primary motoneurons; and the formation of terminal arbors in zebrafish embryos. Part IV discusses developmental processes that depend on diffusible signals and signal gradients. Part V illustrates pattern formation as exemplified in the developing chick hindbrain and in urodele limb regeneration. Part VI highlights gene expression and its regulation by transcription factors or growth factors in rodent development.
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Apoptosis, Cell Signaling, and Human Diseases

Molecular Mechanisms

Author: Rakesh Srivastava

Publisher: Springer Science & Business Media

ISBN: 1597452009

Category: Science

Page: 384

View: 7497

These volumes present a concise synthesis of recent developments in the understanding of both cell survival and apoptotic pathways. Particular attention is given to apoptosis in human diseases, such as different forms of cancer and neurodegenerative diseases. These comprehensive volumes integrate the most innovative and current findings from several related disciplines of scientific research, including pathology, genetics, virology, cell biology, immunology, and molecular biology.
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Cancer Cell Signaling

Methods and Protocols

Author: David M. Terrian

Publisher: Springer Science & Business Media

ISBN: 1592593569

Category: Medical

Page: 333

View: 530

A collection of readily reproducible experimental methods for studying the subversion of normal cell signaling that leads to cancer. Presented in step-by-step detail to ensure successful results, the methods include proven techniques for the investigation of apoptosis and cell death, complementary protocols for manipulating and/or monitoring oncogenic signals in cancer cells, and techniques for studying protein-protein interactions. Analyze multigene families with readily reproducible techniques Employ laser capture microdissection techniques to target cell populations.
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Transduction Mechanisms in Cellular Signaling

Author: Edward A. Dennis,Ralph A. Bradshaw

Publisher: Academic Press

ISBN: 0123838622

Category: Science

Page: 586

View: 7271

"Cell signaling, which is also often referred to as signal transduction or, in more specialized cases, transmembrane signaling, is the process by which cells communicate with their environment and respond temporally to external cues that they sense there. All cells have the capacity to achieve this to some degree, albeit with a wide variation in purpose, mechanism, and response. At the same time, there is a remarkable degree of similarity over quite a range of species, particularly in the eukaryotic kingdom, and comparative physiology has been a useful tool in the development of this field. The central importance of this general phenomenon (sensing of external stimuli by cells) has been appreciated for a long time, but it has truly become a dominant part of cell and molecular biology research in the past three decades, in part because a description of the dynamic responses of cells to external stimuli is, in essence, a description of the life process itself. This approach lies at the core of the developing fields of proteomics and metabolomics, and its importance to human and animal health is already plainly evident"--Provided by publisher.
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Nutrients and Cell Signaling

Author: Janos Zempleni,Krishnamurti Dakshinamurti

Publisher: CRC Press

ISBN: 1420028367

Category: Medical

Page: 760

View: 9230

Cell signaling is at the core of most biological processes from the simplest to the most complex. In addition to unicellular organisms possessing the essential ability to receive inputs with regard to nutrient availability and noxious stimuli, the cells in multicellular organisms require signaling from adjacent, as well as distant cells to maintain normal internal function, including growth, differentiation, and homeostasis. Conversely, the etiology of many disease processes, such as those involving immune system dysfunction and tumor development, have been traced to aberrant cell signaling. Nutrients and Cell Signaling, in presenting contributions from a wide array of experts in the field, fully delineates the role of nutrients in cell signaling. The text emphasizes broad concepts and covers all major groups of nutrients. Contributors discuss the role of carbohydrates, amino acids, lipids, vitamins, minerals, and trace elements in essential processes such as cell proliferation, immune function, and DNA repair. The editors have organized the work to provide select examples organized under these contemporary research areas: Nuclear receptors, transcription factors, and signaling cascades Amino acids, lipids, and glycation Insulin release, signaling, and insulin resistance Calcium-dependent signaling Feeding and nutrient homeostasis Nutrients and Cell Signaling answers the need in the post-genomic era, for an authoritative resource that provides an in-depth understanding of how these complex and dynamic biomolecular networks control cell function. Those professionals and students in molecular biology, nutrition, biochemistry, as well as any branch involved with cell signaling and function will find this book to be an invaluable tool in promoting both understanding and further inquiry.
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Polyamine Cell Signaling

Physiology, Pharmacology, and Cancer Research

Author: Jian-Ying Wang

Publisher: Springer Science & Business Media

ISBN: 1597451452

Category: Science

Page: 490

View: 7712

Polyamines are organic cations found in all eukaryotic cells and intimately involved in, and required for, distinct biological functions. An increasing body of evidence indicates that the regulation of cellular polyamines is a central convergence point for the multiple signaling pathways driving various cellular functions. Over the last decade, considerable progress has been made in und- standing the molecular functions of cellular polyamines. These significant findings provide a fundamental basis to not only define the exact role of polyamines in physiology, but also to develop new therapeutic approaches for cancers and other diseases. The major objective of this book is to provide a timely and long lasting guide for investigators in the fields of polyamines, physiology, pharmacology, and cancer research. It will provide a foundation based on research and address the potential for subsequent applications in clinical practice. Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research is divided into four main parts: Part I: Polyamines in Signal Transduction of Cell Proliferation Part II: Polyamines in Cellular Signaling of Apoptosis, Carcinogenesis, and Cancer Therapy Part III: Polyamines in Cell Motility and Cell–Cell Interactions Part IV: Polyamine Homeostasis and Transport This book not only covers the current state-of-the-art findings relevant to cellular and molecular functions of polyamines, but also provides the underlying conceptual basis and knowledge regarding potential therapeutic targeting of polyamines and polyamine metabolism. These points are addressed by int- nationally recognized experts in their contributions to this book.
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Cancer Cell Signaling

Targeting Signaling Pathways Toward Therapeutic Approaches to Cancer

Author: Kasirajan Ayyanathan

Publisher: CRC Press

ISBN: 1771880678

Category: Medical

Page: 410

View: 5316

Cell signaling is a field that studies how cells communicate to control basic activities and respond to their environment. When looking specifically at cancer cells, researchers can gain a better understanding of cancer on a cellular level, an understanding that may have implications for developing new treatments. The current volume provides an overview of the field and how various cell biology techniques are used to better understand cancer on a cellular level. This easily accessible reference volume offers a comprehensive look at the field of cancer cell signaling. Edited by a researcher from Florida Atlantic University, Cancer Cell Signaling: Targeting Signaling Pathways Towards Therapeutic Approaches to Cancer is an authoritative and easy-to-use reference.
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Hydrogen Peroxide and Cell Signaling

Author: N.A

Publisher: Academic Press

ISBN: 0124055400

Category: Science

Page: 384

View: 9951

This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the third of three volumes on hydrogen peroxide and cell signaling, and includes chapters on such topics as the biological chemistry of hydrogen peroxide, reactive oxygen species in the activation of MAP kinases, and investigating the role of reactive oxygen species in regulating autophagy. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers hydrogen peroxide and cell signaling Contains chapters on such topics as the biological chemistry of hydrogen peroxide, reactive oxygen species in the activation of MAP kinases, and investigating the role of reactive oxygen species in regulating autophagy
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Thiol Redox Transitions in Cell Signaling, Part A

Chemistry and Biochemistry of Low Molecular Weight and Protein Thiols

Author: N.A

Publisher: Academic Press

ISBN: 9780123813466

Category: Science

Page: 416

View: 1507

Thiol Redox Transitions in Cell Signaling, Part A, along with its companion (volume 475), presents methods and protocols dealing with thiol oxidation-reduction reactions and their implications as they relate to cell signaling. This first installment of Cadenas and Packer's two-volume treatment specifically deals with glutathionylation and dethiolation, and peroxide removal by peroxiredoxins/thioredoxins and glutathione peroxidases. The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Over 450 volumes have been published to date, and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. Along with companion volume, provides a full overview of techniques necessary to the study of thiol redox in relation to cell signaling Gathers tried and tested techniques from global labs, offering both new and tried-and-true methods Relevant background and reference information given for procedures can be used as a guide to developing protocols in a number of disciplines
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Cell Signaling in Vascular Inflammation

Author: Jahar Bhattacharya

Publisher: Springer Science & Business Media

ISBN: 1592599095

Category: Medical

Page: 222

View: 8305

A comprehensive survey by leading basic and clinical researchers of the signal transduction mechanisms responsible for lung inflammation, including vascular hyperpermeability, white cell accumulation, and vascular remodeling. The authors cut across disciplines to bring together a broad-based presentation of inflammatory challenge, both in the initial phases of the inflammatory response, as well as in the more prolonged phase of genomic involvement. The book illuminates not only the processes of lung inflammation, but also the potential for developing new therapeutic strategies to combat inflammatory lung disease.
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